DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles

Neurobiology of Disease

Volumn 14, Issue 2, 2003, Pages 240-250

  Evans, S J ^a,b   Choudary, P V ^a,c   Vawter, M P ^a,d   Li, J ^a,e   Meador Woodruff, J H ^a,f   Lopez, J F ^a,f   Burke, S M ^a,b   Thompson, R C ^a,f   Myers, R M ^a,e   Jones, E G ^a,c   Bunney, W E ^a,d   Watson, S J ^a,b   Akil, H ^a,b  

^a Pritzker Consortium Severe P   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Cerebellum; Cingulate cortex; Depression; Microarray; Prefrontal cortex; Psychiatric disorder; Schizophrenia

Indexed keywords

TRANSCRIPTION FACTOR;

ADULT; AGED; ARTICLE; BRAIN CORTEX; BRAIN REGION; CEREBELLUM CORTEX; CINGULATE GYRUS; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; HUMAN; HUMAN TISSUE; MALE; NERVOUS SYSTEM DEVELOPMENT; PREFRONTAL CORTEX; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0142219847     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-9961(03)00126-8     Document Type: Article

References (47)

1. Allen K.M., Gleeson J.G., Bagrodia S., et al. PAK3 mutation in nonsyndromic X-linked mental retardation. Nat. Genet. 20:1998;25-30.
2. Bagrodia S., Derijard B., Davis R.J., Cerione R.A. Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 270:1995;27995-27998.
3. Bahjaoui-Bouhaddi M., Padilla F., Nicolet M., Cifuentes-Diaz C., Fellmann D., Mege R.M. Localized deposition of M-cadherin in the glomeruli of the the granular layer during the postnatal development of mouse cerebellum. J. Comp. Neurol. 378:1997;180-195.
4. Brene S., Lindefors N., Kopp J., Sedvall G., Persson H. Regional distribution of neuropeptide Y mRNA in postmortem human brain. Brain Res. Mol. Brain Res. 6:1989;241-249.
5. Bronstein D.M., Schafer M.K., Watson S.J., Akil H. Evidence that beta-endorphin is synthesized in cells in the nucleus tractus solitarius detection of POMC mRNA . Brain Res. 587:1992;269-275.
6. Caberlotto L., Hurd Y.L. Reduced neuropeptide Y mRNA expression in the prefrontal cortex of subjects with bipolar disorder. NeuroReport. 10:1999;1747-1750.
7. Eastwood S.L., Burnet P.W., Gittins R., Baker K., Harrison P.J. Expression of serotonin 5-HT(2A) receptors in the human cerebellum and alterations in schizophrenia. Synapse. 42:2001;104-114.
8. Evans, S.J., Datson, N.A., Kabbaj, M, et al., 2002. Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis. Eur. J. Neurosci in press.
9. Gold S.J., Ni Y.G., Dohlman H.G., Nestler E.J. Regulators of G-protein signaling (RGS) proteins region-specific expression of nine subtypes in rat brain . J. Neurosci. 17:1997;8024-8037.
10. Horie M., Okutomi K., Taniguchi Y., Ohbuchi Y., Suzuki M., Takahashi E. Isolation and characterization of a new member of the human Ly6 gene family (LY6H). Genomics. 53:1998;365-368.
11. Itoh A., Miyabayashi T., Ohno M., Sakano S. Cloning and expressions of three mammalian homologues of Drosophila Slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Brain Res. Mol. Brain Res. 62:1998;175-186.
12. Jones E.G. A new view of specific and nonspecific thalamocortical connections. Adv. Neurol. 77:1998;49-71. discussion 72-73.
13. Jones E.G., Hendry S.H., Liu X.B., Hodgins S., Potkin S.G., Tourtellotte W.W. A method for fixation of previously fresh-frozen human adult and fetal brains that preserves histological quality and immunoreactivity. J. Neurosci. Methods. 44:1992;133-144.
14. Khachaturian H., Lewis M.E., Haber S.N., Akil H., Watson S.J. Proopiomelanocortin peptide immunocytochemistry in rhesus monkey brain. Brain Res. Bull. 13:1984;785-800.
15. Leifer D., Krainc D., Yu Y.T., et al. MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proc. Natl. Acad. Sci. USA. 90:1993;1546-1550.
16. Lofberg C., Agren H., Harro J., Oreland L. Cholecystokinin in CSF from depressed patients possible relations to severity of depression and suicidal behaviour . Eur. Neuropsychopharmacol. 8:1998;153-157.
17. Lowe W.L. Jr., Schaffner A.E., Roberts C.T. Jr., LeRoith D. Developmental regulation of somatostatin gene expression in the brain is region specific. Mol. Endocrinol. 1:1987;181-187.
18. Manser E., Chong C., Zhao Z.S., et al. Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. J. Biol. Chem. 270:1995;25070-25078.
19. Mansour A., Fox C.A., Akil H., Watson S.J. Opioid-receptor mRNA expression in the rat CNS anatomical and functional implications . Trends Neurosci. 18:1995;22-29.
20. Mariani M., Corradi A., Baldessari D., et al. Mab21, the mouse homolog of a C. elegans cell-fate specification gene, participates in cerebellar, midbrain and eye development. Mech. Dev. 79:1998;131-135.
21. 2+/calmodulin- dependent protein kinase II. Isozymic forms from rat forebrain and cerebellum. J. Biol. Chem. 260:1985;1696-1704.
22. Meador-Woodruff J.H. Update on dopamine receptors. Ann. Clin. Psychiatry. 6:1994;79-90.
23. Minthon L., Edvinsson L., Gustafson L. Somatostatin and neuropeptide Y in cerebrospinal fluid correlations with severity of disease and clinical signs in Alzheimer's disease and frontotemporal dementia . Dement. Geriatr. Cogn. Disord. 8:1997;232-239.
24. Mirnics K., Middleton F.A., Stanwood G.D., Lewis D.A., Levitt P. Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol. Psychiatry. 6:2001;293-301.
25. Mitsui K., Nakajima D., Ohara O., Nakayama M. Mammalian fat3 a large protein that contains multiple cadherin and EGF-like motifs . Biochem. Biophys. Res. Commun. 290:2002;1260-1266.
26. Mohler H., Malherbe P., Draguhn A., Richards J.G. GABAA-receptors structural requirements and sites of gene expression in mammalian brain . Neurochem. Res. 15:1990;199-207.
27. Murphy D.B., Wiese S., Burfeind P., et al. Human brain factor 1, a new member of the fork head gene family. Genomics. 21:1994;551-557.
28. Nakamura T., Muraoka S., Sanokawa R., Mori N. N-Shc and Sck, two neuronally expressed Shc adapter homologs their differential regional expression in the brain and roles in neurotrophin and Src signaling . J. Biol. Chem. 273:1998;6960-6967.
29. O'Hara B.F., Andretic R., Heller H.C., Carter D.B., Kilduff T.S. GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions. Brain Res. Mol. Brain Res. 28:1995;239-250.
30. Pati D., Keller C., Groudine M., Plon S.E. Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. Mol. Cell Biol. 17:1997;3037-3046.
31. Represa A., Deloulme J.C., Sensenbrenner M., Ben-Ari Y., Baudier J. Neurogranin immunocytochemical localization of a brain-specific protein kinase C substrate . J. Neurosci. 10:1990;3782-3792.
32. Salinas M., Duprat F., Heurteaux C., Hugnot J.P., Lazdunski M. New modulatory alpha subunits for mammalian Shab K+ channels. J. Biol. Chem. 272:1997;24371-24379.
33. Sandberg R., Yasuda R., Pankratz D.G., et al. Regional and strain-specific gene expression mapping in the adult mouse brain. Proc. Natl. Acad. Sci. USA. 97:2000;11038-11043.
34. Seguela P., Wadiche J., Dineley-Miller K., Dani J.A., Patrick J.W. Molecular cloning, functional properties, and distribution of rat brain alpha 7 a nicotinic cation channel highly permeable to calcium . J. Neurosci. 13:1993;596-604.
35. Sharma R.P., Bissette G., Janicak P., Davis J.M., Nemeroff C.B. Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder the effects of antipsychotic treatment . Schizophr. Res. 13:1994;173-177.
36. Sharma R.P., Bissette G., Janicak P.G., Davis J.M., Nemeroff C.B. Elevation of CSF somatostatin concentrations in mania. Am. J. Psychiatry. 152:1995;1807-1809.
37. Su A.I., Cooke M.P., Ching K.A., et al. Large-scale analysis of the human and mouse transcriptomes. Proc. Natl. Acad. Sci. USA. 99:2002;4465-4470.
38. Takeuchi T., Misaki A., Sonobe H., Liang S.B., Ohtsuki Y. Is T-cadherin (CDH13, H-cadherin) expression related to lung metastasis of osteosarcoma? Histopathology. 37:2000;193-194.
39. Tang X.X., Pleasure D.E., Ikegaki N. cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors. Genomics. 41:1997;17-24.
40. Tighilet B., Hashikawa T., Jones E.G. Cell- and lamina-specific expression and activity-dependent regulation of type II calcium/calmodulin- dependent protein kinase isoforms in monkey visual cortex. J. Neurosci. 18:1998;2129-2146.
41. Turecki G., Briere R., Dewar K., et al. Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. Am. J. Psychiatry. 156:1999;1456-1458.
42. Vallano M.L., Beaman-Hall C.M., Mathur A., Chen Q. Astrocytes express specific variants of CaM KII delta and gamma; but not alpha and beta, that determine their cellular localizations. Glia. 30:2000;154-164.
43. Vawter, M.P., Evans, S.J., Choudary, P.V., et al., 2003. Gender specific gene expression in postmortem human brain: localization to sex chromosomes. In Submission.
44. Vogt B.A., Finch D.M., Olson C.R. Functional heterogeneity in cingulate cortex the anterior executive and posterior evaluative regions . Cereb. Cortex. 2:1992;435-443.
45. Weinberger D.R., Egan M.F., Bertolino A., et al. Prefrontal neurons and the genetics of schizophrenia. Biol. Psychiatry. 50:2001;825-844.
46. Zhao X., Lein E.S., He A., Smith S.C., Aston C., Gage F.H. Transcriptional profiling reveals strict boundaries between hippocampal subregions. J. Comp. Neurol. 441:2001;187-196.
47. Zirlinger M., Kreiman G., Anderson D.J. Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei. Proc. Natl. Acad. Sci. USA. 98:2001;5270-5275.