Fructose breath hydrogen test - Is it really a harmless diagnostic procedure?

Digestive Diseases

Volumn 21, Issue 3, 2003, Pages 276-278

  Müller, Peter ^a,b,d   Meier, C ^b   Bohme H J ^b   Richter, T ^b,c  

^a Department of Gastroenterology   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c Klinikum St Georg   (Germany)

^d Helios Krankenhaus Leisnig   (Germany)

Author keywords

Fructose breath hydrogen test; Fructose malabsorption; Hereditary fructose intolerance

Indexed keywords

FRUCTOSE; GLUCOSE; RECOMBINANT GROWTH HORMONE;

ABDOMINAL PAIN; ADOLESCENT; ARTICLE; CASE REPORT; CHRONIC PAIN; CLINICAL FEATURE; COMPLICATION; DIAGNOSTIC ERROR; DIAGNOSTIC TEST; FRUCTOSE HYDROGEN BREATH TEST; GROWTH HORMONE DEFICIENCY; GROWTH RETARDATION; HEREDITARY FRUCTOSE INTOLERANCE; HUMAN; HYDROGEN BREATH TEST; HYPOGLYCEMIA; MALE; METABOLIC ACIDOSIS; MUSCLE HYPOTONIA; NUTRITIONAL STATUS; PRIORITY JOURNAL; TACHYCARDIA; UNCONSCIOUSNESS; VOMITING;

ABDOMINAL PAIN; ADOLESCENT; BREATH TESTS; DIAGNOSIS, DIFFERENTIAL; FRUCTOSE; FRUCTOSE INTOLERANCE; GROWTH DISORDERS; HUMANS; MALE; SENSITIVITY AND SPECIFICITY;

EID: 0142218846     PISSN: 02572753     EISSN: None     Source Type: Journal    
DOI: 10.1159/000073348     Document Type: Article

References (21)

1. Ramussen JJ, Gudmand-Hoyer E: Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides. Gut 1986;27:1161-1168.
2. Ledochowski M, Widner B, Bair H, Probst T, Fuchs D: Fructose- and sorbitol-reduced diet improves mood and gastrointestinal disturbances in fructose malabsorbers. Scand J Gastroenterol 2002;35:1113-1126.
3. Burant CF, Takeda J, Brot-Laroche E, Bell GI, Davidson NO: Fructose transporter in human spermatozoa and small intestine is GLUT-5. J Biol Chem 1992;267:14523-14526.
4. Wassermann D, Hoekstra JH, Tolia V, Taylor CJ, Kirschner S, Takeda J, Bell GI, Taub R, Rand EB: Molecular analysis of the fructose transporter gene (GLUT-5) in isolated fructose malabsorption. J Clin Invest 1996;98:2398-2402.
5. Helliwell, PA, Richardson M, Affleck J, Kellett, GL: Regulation of GLUT-5, GLUT-2 and intestinal brush-border fructose absorption by the extracellular signal-regulated kinase, p38 mitogen-activated kinase and phosphatidylinositol 3-kinase intracellular signalling pathways: Implications for adaptation to diabetes. Biochem J 2000;50:163-169.
6. Barnes G, McKellan W, Lawrence S: Detection of fructose malabsorption by breath hydrogen test in a child with diarrhea. J Pediatr 1983;103:575-577.
7. Bond, JH, Levitt MD: Investigation of small bowel transit time in man utilizing pulmonary hydrogen (H2) measurements. J Lab Clin Med 1975;85:546-555.
8. Romagnuolu J, Schiller D, Bailey RJ: Using breath tests wisely in a gastroenterology practice: An evidence-based review of indications and pitfalls in interpretation. Am J Gastroenterol 2002;97:1113-1126.
9. Hoekstra JH: Fructose breath hydrogen test in infants with chronic non-specific diarrhoea. Eur J Pediatr 1995;154:362-364.
10. Götze H, Mahdi A: Role of fructose malabsorption in dysfunctional bowel disorders. Monatsschr Kinderheilkd 1992;140:814-817.
11. Cox TM: Fructose intolerance: Diet and inheritance. Proc Nutr Soc 1991;50:305-309.
12. Wössmann W, Wiemann J, Körber F, Görtner L: Hereditäre Fruktoseintoleranz (HFI) als Ursache einer isolierten γ-GT-Erhöhung bei einem 5-jährigen Jungen mit Hepatomegalie. Klin Pädiatr 2000;212:108-109.
13. Kneepkens CMF, Vonk RJ, Fernandes J: Incomplete intestinal absorption of fructose. Arch Dis Child 1984;59:735-738.
14. Steinmann B, Gitzelmann R, van den Berghe G: Disorders of fructose metabolism; in Scriver CR, Beaudet AL, Sly WS, Valle D (eds): The Metabolic and Molecular Bases of Inherited Disease, ed 8. New York, McGraw-Hill, 2001, pp 1489-1520.
15. Chambers RA, Pratt RTC: Idiosyncrasy to fructose. Lancet 1956;271:340.
16. Hers HG, Joassin G: An anomaly in hepatic aldolase during fructose intolerance. Enzymol Biol Clin 1961;1:4-14.
17. Tolan DR: Molecular basis of hereditary fructose intolerance: Mutations and polymorphisms in the human aldolase B gene. Hum Mutat 1995;6:210-218.
18. Müller P, Koppelt B, Böhme HJ, Bührdel P: Detection of DNA mutations in German patients with hereditary fructose intolerance. Amino Acids 1997;12:389.
19. Koppelt B, Pöge AP, Müller P, Bührdel P, Böhme HJ: Molecular biological investigation in a family with hereditary fructose intolerance and diagnostic consequences. Monatsschr Kinderheilkd 1996;144:383-386.
20. Burmeister LA, Valdivia T, Nuttall FQ: Adult hereditary fructose intolerance. Arch Intern Med 1991;151:773-776.
21. Cox TM: Iatrogenic deaths in hereditary fructose intolerance. Arch Dis Child 1993;69:413-415.