Amphetamines induce ubiquitin-positive inclusions within striatal cells

Neurological Sciences

Volumn 24, Issue 3, 2003, Pages 182-183

  Fornai, F ^a,b   Lazzeri, G ^a   Lenzi, P ^a   Gesi, M ^a   Ferrucci, M ^a   Soldani, P ^a   Pellegrini, A ^a   Capobianco, L ^b   De Blasi, A ^b   Ruggieri, S ^b,c   Paparelli, A ^a  

^a UNIVERSITY OF PISA   (Italy)

^b IRCCS NEUROMED   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 4 AMINOBUTYRIC ACID RECEPTOR; AMPHETAMINE DERIVATIVE; DOPAMINE; LEVODOPA; METHAMPHETAMINE; MONOAMINE OXIDASE INHIBITOR; PARGYLINE; RESERPINE; TYROSINE DERIVATIVE; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; CELL INCLUSION; CONTROLLED STUDY; CORPUS STRIATUM; DEGRADATION; DOPAMINE METABOLISM; DOPAMINE RELEASE; DRUG MECHANISM; ELECTRON MICROSCOPY; EXPERIMENTATION; EXTRACELLULAR SPACE; MALE; MOUSE; MOUSE STRAIN; NERVE CELL DEGENERATION; NONHUMAN;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; CELL COUNT; CORPUS STRIATUM; DOPAMINE; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GLUTAMATE DECARBOXYLASE; INCLUSION BODIES; ISOENZYMES; MALE; METHAMPHETAMINE; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEURONS; UBIQUITIN;

EID: 0142217549     PISSN: 15901874     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10072-003-0120-4     Document Type: Article

References (7)

1. Fornai F, Gesi M, Lenzi P, Ferrucci M, Pellegrini A, Ruggieri S, Casini A, Paparelli A (2002) Striatal postsynaptic ultrastructural alterations following methylenedioxymethamphetamine administration. Ann NY Acad Sci 965:381-398
2. Filloux F, Townsend JJ (1993) Pre- and postsynaptic neurotoxic effects of dopamine demonstrated by intrastriatal injection. Exp Neurol 119:79-88
3. Jakel RJ, Maragos WF (2000). Neuronal cell death in Huntington's disease: a potential role for dopamine. Trends Neurosci 23:239-245
4. Petersen A, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P, Sulzer D (2001) Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneratio. Hum Mol Genet 10:1243-1254
5. Bence NF, Sampat RM, Kopito, RR (2001) Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292:1552-1555
6. Chung KK, Dawson VL, Dawson TM (2001) The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders. Trends Neurosci 24:S7-S14
7. Conway KA, Rochet JC, Bienganski RM, Lansbury PT Jr (2001) Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 294:1346-1349