Use of N-trifluoroacetyl-protected amino acid chlorides in peptide coupling reactions with virtually complete preservation of stereochemistry

Tetrahedron

Volumn 59, Issue 45, 2003, Pages 9019-9029

  Jass, Paul A ^a,c   Rosso, Victor W ^a   Racha, Saibaba ^b   Soundararajan, Nachimuthu ^a   Venit, John J ^a   Rusowicz, Andrew ^a   Swaminathan, Shankar ^a   Livshitz, Julia ^a   Delaney, Edward J ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b BRISTOL MYERS SQUIBB COMPANY   (United States)

^c Cambrex Corporation   (United States)

Author keywords

Acid chloride formation; Amide formation; Azlactone formation; Kinetic rate of coupling; Kinetic rate of racemization; N trifluoroacetyl protection; Peptide coupling; Schotten Baumann

Indexed keywords

AMINO ACID; LACTONE DERIVATIVE; PEPTIDE; TRIFLUOROACETIC ACID;

ARTICLE; LOW TEMPERATURE; PH; PRESERVATION; PRIORITY JOURNAL; PROTECTION; PURIFICATION; STEREOCHEMISTRY;

EID: 0142217503     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2003.02.002     Document Type: Article

References (15)

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