Ptychodiscus brevis toxin enhances the frequency-dependent depression of the monosynaptic reflex in neonatal rat spinal cord in vitro

Toxicology Letters

Volumn 145, Issue 3, 2003, Pages 231-237

  Deshpande, S B ^a   Singh, J N ^a   Das Gupta, S ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Brevetoxins; Homosynaptic depression; MSR; NMDA receptor; Synaptic transmission

Indexed keywords

BREVETOXIN; MAGNESIUM ION;

ANIMAL TISSUE; ARTICLE; COMPARATIVE TOXICOLOGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DINOFLAGELLATE; DORSAL ROOT; EVOKED SPINAL CORD RESPONSE; FEMALE; MALE; MONOSYNAPTIC REFLEX; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PTYCHODISCUS BREVIS; PULSE RATE; RAT; SPINAL CORD STIMULATION; SPINAL REFLEX; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION; VENTRAL ROOT;

PTYCHODISCUS;

EID: 0142216467     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(03)00292-3     Document Type: Article

References (21)

1. Alam M.R., Sanduza R., Hossain M.B., van der Helm D. Gymnodinium breve toxins. 1. Isolation and X-ray structure of O,O-dipropyl-(E)-2-(1-methyl-2- oxoproylinidephosphoro-hydro-thioate-(E)-oxime from the red tide dinoflagellate G. breve. J. Am. Chem. Soc. 104:1982;5232.
2. Baden D.G., Bikhazi G., Decker S.J., Foldes F.F., Leung I. Neuromuscular blocking action of two brevetoxins from the Florida red tide organism Ptychodiscus brevis. Toxicon. 22:1984;75-84.
3. Borison H.L., McCarthy L.E., Elious S. Neurological analysis of respiratory, cardiovascular and neuromuscular effects of brevetoxin in cats. Toxicon. 23:1985;517-524.
4. Carp J.S., Ohno Y., Warnick J.E. Prevention of phencyclidine-induced depression of the segmental reflex by l-3,4-dihydroxy-phenylalanine in the rat spinal cord in vitro. J. Pharmacol. Exp. Ther. 248:1989;1048-1053.
5. Danysz W., Parsons C.G. Glycine and N-Methyl-D-aspartate receptors: physiological significance and possible therapeutic applications. Pharmacol. Rev. 50:1998;597-664.
6. Deshpande S.B. Significance of monosynaptic and polysynaptic reflexes in rat spinal cord in vitro. Ind. J. Exp. Biol. 31:1993;850-854.
7. Deshpande S.B., Das Gupta S. Diisopropylphosphoro-fluoridate-induced depression of segmental monosynaptic transmission in neonatal rat spinal cord is also mediated by increased axonal activity. Toxicol. Lett. 90:1997;177-182.
8. Deshpande S.B., Warnick J.E. Temperature dependence of reflex transmission in the neonatal rat spinal cord in vitro: influence on strychnine and bicuculline sensitive inhibitions. Neuropharmacology. 27:1988;1033-1037.
9. Kaushik M.P., Parashar B.D., Swamy R.V. Synthesis of Gymnodinium breve toxin. Ind. J. Chem. 27:1988;1150-1151.
10. Koley J., Sinha S., Basak A.K., Das M., Dube S.N., Mazumder P.K., Gupta A.K., Das Gupta S., Koley B. Cardiovascular and respiratory changes following exposure to a synthetic toxin of Ptychodiscus brevis. Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. 293:1995;483-486.
11. Lev-Tov A., Pinco M. In vitro studies of prolonged synaptic depression in the neonatal rat spinal cord. J. Physiol. 447:1992;149-169.
12. Maruoka Y., Ohno Y., Tanaka H., Yasuda H., Ohtani K.I., Sakamoto H., Kawabe A., Tamamura C., Nakamura M. Selective depression of the spinal polysynaptic reflexes by the NMDA receptor antagonists in an isolated spinal cord in vitro. Gen. Pharmacol. 29:1997;645-649.
13. Nowak L., Bregestooski P., Ascher P., Herbert A., Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurons. Nature. 307:1984;462-465.
14. Ohno Y., Warnick J.E. Selective depression of the segmental polysynaptic reflex by phencyclidine and its analogues in the rat in vitro: interaction with N-methyl-D-aspartate receptors. J. Pharmacol. Exp. Ther. 252:1990;246-252.
15. Poli M.A., Templeton C.B., Thompson W.L., Hewetson J.F. Distribution and elimination of brevetoxin PbTx-3 in rats. Toxicon. 28:1990;903-910.
16. Puil, E., 1983. Action and interactions of S-glutamate in the spinal cord. In: Davidoff, R.A. (Ed.), Handbook of Spinal Cord, vol. 1. Marcel Dekker, New York, pp. 104-169.
17. Singh J.N., Deshpande S.B. Involvement of N-methyl-D-aspartate receptors for the Ptychodiscus brevis toxin-induced depression of monosynaptic and polysynaptic reflexes in neonatal rat spinal cord in vitro. Neuroscience. 115:2002;1189-1197.
18. Singh J.N., Das Gupta S., Gupta A.K., Dube S.N., Deshpande S.B. Relative potency of synthetic analogs of Ptychodiscus brevis toxin in depressing synaptic transmission evoked in neonatal rat spinal cord in vitro. Toxicol. Lett. 128:2002;177-183.
19. Skulberg O.M., Codd G.A., Carmichael W.W. Toxic blue green algal blooms in Europe: a growing problem. Ambio. 13:1984;244-247.
20. Tolliver J.M., Warnick J.E. Aminoglycoside-induced blockade of reflex activity in the isolated spinal cord from the neonatal rat. Neurotoxicology. 8:1987;255-268.
21. Warnick J.E., Deshpande S.B., Yang Q.Z., Das Gupta S. Biphasic action of sarin on monosynaptic reflex in the neonatal rat spinal cord in vitro. Arch. Toxicol. 67:1993;302-306.