Stress/strain/life revisited. Quantification by blood pressure chronomics: Benetensive, transtensive or maletensive chrono-vasculo-neuro-immuno-modulation

Biomedicine and Pharmacotherapy

Volumn 57, Issue SUPPL. 1, 2003, Pages 136-163

  Halberg, Franz ^a   Cornélissen, Germaine ^a   Spector, Novera H ^a   Sonkowsky, Robert P ^a   Otsuka, Kuniaki ^a   Baciu, Ion ^a   Hriscu, Monica ^a   Schwartzkopff, Othild ^a   Bakken, Earl E ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CORTICOTROPIN; MELATONIN;

ADAPTATION SYNDROME; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CHRONOBIOLOGY; CHRONOSEQUENCE; CIRCADIAN RHYTHM; CIRCULATION; COMPUTER ANALYSIS; CONFERENCE PAPER; DATA ANALYSIS; DIASTOLIC BLOOD PRESSURE; ENDOCRINOLOGY; EOSINOPHIL; EXERCISE; HEART RATE; HEART RATE VARIABILITY; HOMEOSTASIS; HORMONE ACTION; HUMAN; HYPERTENSION; HYPOTENSION; IMMUNITY; IMMUNOMODULATION; INFORMATION PROCESSING; LEISURE; MEASUREMENT; MENTAL PERFORMANCE; NERVOUS SYSTEM; PHYSICAL ACTIVITY; PHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SELF EVALUATION; STIMULUS; STRESS; TECHNIQUE; TENSION;

EID: 0142200271     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2003.08.017     Document Type: Conference Paper

References (165)

1. Baciu I. Fiziologie. 1977;itura Didactica si Pedagogica, Bucharest. 874. p.
2. Spector N.H. Information explosions in an old-new research domain. Cruse J.M., Lewis R.E. Jr. The year in immunology, 1984-1985. 1985;S. Karger, Basel.
3. Papers from the workshop held by the International Working Group on Neuroimmunomodulation (IWGN) at the National Library of Medicine (of the National Institutes of Health), Bethesda, MD, 27 November-3 December 1984 London: Gordon and Breach 1987 2nd Spector N.H., Bulloch K., Fox B.H., Jankovic B.D., Kerza-Kwaitecki A.P., Monjan A.A., Pierpaoli W. Neuroimmunomodulation: Proceedings of the First International Workshop on Neuroimmunomodulation. 1985;IWGN, Bethesda, MD.
4. Spector N.H. From the president (editorial). NIM Newsletter. 5:(1):1990;1.
5. Spector N.H., Dolina S., Cornélissen G., Halberg F., Markovic B.M., Jankovic B.D. Neuroimmunomodulation: neuroimmune interactions with the environment. Fregly M.J., Blatteis C.M. Handbook of physiology, section 4: environmental physiology. 1995;1537-1550 American Physiological Society/Oxford University Press, New York.
6. Fabris N., Jankovic B.D., Markovic B.M., Spector N.H. Ontogenetic and phylogenetic mechanisms of neuroimmunomodulation: from molecular biology to psychosocial sciences. 650:1992;369. Ann NY Acad Sci.
7. Cornélissen G., Halberg F. Toward a "chron-sensus" on neuroimmunomodulation, with "modulation" operationally and inferentially defined. Fabris N., Jankovic B.D., Markovic B.M., Spector N.H. Ontogenetic and phylogenetic mechanisms of neuroimmunomodulation: from molecular biology to psychosocial sciences. 650:1992;60-67. Ann NY Acad Med Sci.
8. Halberg F., Cornélissen G., Katinas G.S., Watanabe Y., Otsuka K., Maggioni C., et al. Feedsidewards: intermodulation (strictly) among time structures, chronomes, in and around us, and cosmo-vasculo-neuroimmunity. About ten-yearly changes: what Galileo missed and Schwabe found. Proceedings of the Fourth International Congress International Society for Neuroimmunomodulation, Lugano, Switzerland, 29 September-2 October 1999 Ann NY Acad Sci Conti A., Maestroni G.J.M., McCann S.M., Sternberg E.M., Lipton J.M., Smith C.C. Neuroimmunomodulation. 917:2000;348-376.
9. Osler W. Modern medicine: its theory and practice. vol. 4: Diseases of the circulatory system - diseases of the blood - diseases of the spleen, thymus and lymph-glands. 1908;430-443 Lea and Febiger, Philadelphia.
10. Sternberg E.M. Does stress make you sick and belief make you well? The science connecting body and mind. Proceedings of the Fourth International Congress International Society for Neuroimmunomodulation, Lugano, Switzerland, 29 September-2 October 1999 Ann NY Acad Sci Conti A., Maestroni G.J.M., McCann S.M., Sternberg E.M., Lipton J.M., Smith C.C. Neuroimmunomodulation. 917:2000;1-3.
11. Halberg F., Cornélissen G., Schwartzkopff O. Neuroendocrinol Lett. 23:2002;262-265. [Book review of Deppert W, Köther K, Kralemann B, Lattmann C, Martens N, Schaefer J, editors. Selbstorganisierte Systemzeiten: Ein interdisziplinärer Diskurs zur Modellierung lebender Systeme auf der Grundlage interner Rhythmen.].
12. Halberg F. Chronobiology. Annu Rev Physiol. 31:1969;675-725.
13. Halberg F., Cornélissen G., Otsuka K., Schwartzkopff O., Halberg J., Bakken E.E. Chronomics. Biomed Pharmacother. 55:(Suppl 1):2001;153-190.
14. Cornélissen G., Halberg F. Introduction to chronobiology.:1994. Medtronic chronobiology Seminar No. 7 Library of Congress Catalog Card No. 94-060580; while supply lasts from Patrick Delmore, Head, Communications, Medtronic Inc., MS LC255, 710 Medtronic Parkway, Minneapolis, MN 55432-5604; e-mail patrick_allen_delmore@medtronic.com.
15. Halberg F., Cornélissen G., Wall D., Otsuka K., Halberg J., Katinas G., et al. Engineering and governmental challenge: 7-day/24-h chronobiologic blood pressure and heart rate screening: Part I. Biomed Instrum Technol. 36:2002;89-122.
16. Halberg F., Cornélissen G., Wall D., Otsuka K., Halberg J., Katinas G., et al. Engineering and governmental challenge: 7-day/24-h chronobiologic blood pressure and heart rate screening: Part II. Biomed Instrum Technol. 36:2002;183-197.
17. Halberg F., Visscher M.B., Flink E.B., Berge K., Bock F. Diurnal rhythmic changes in blood eosinophil levels in health and in certain diseases. J Lancet (Minneapolis). 71:1951;312-319.
18. Halberg F. Some physiological and clinical aspects of 24-h periodicity. J Lancet (Minneapolis). 73:1953;20-32.
19. Sutcliffe J., Duin N. A history of medicine. 1992;Barnes & Noble, New York.
20. Halberg F., Cornélissen G., Halpin C., Burchell H., Watanabe Y., Kumagai Y., et al. Fleeting "monitor?", "conflict?" or "grief-associated" blood pressure disorders: MESOR-hypertension and circadian hyperamplitudetension (CHAT). Euro Rehab. 6:1996;225-240.
21. Halberg F., Cornélissen G., Otsuka K., Katinas G.S., Schwartzkopff O., Halpin C., et al. Chronomics (the study of time structures, chronomes) detects altered vascular variabilities constituting risks greater than hypertension: with an illustrative case report. Mitro P., Pella D., Rybar R., Valocik G. Proceedings of the Second Congress on Cardiovascular Diseases, Kosice, Slovakia, 25-27 April 2002. 2002;223-258 Monduzzi Editore, Bologna.
22. Cornélissen G., Halberg F., Wall D., Siegelova J., Zaslavskaya R.M. How long to screen: ice hockey game and transient circadian hyperamplitudetension, CHAT. Scr Medica (Brno). 70:1997;189-198.
23. Halberg F., Cornélissen G. Resolution from a meeting of the International Society for Research on Civilization Diseases and the Environment (New SIRMCE Confederation), Brussels, Belgium, 17-18 March 1995: fairy tale or reality? 1994. Medtronic Chronobiology Seminar No. 8 18 figures. Available from: [accessed].
24. Halberg F., Bittner J.J., Gully R.J., Albrecht P.G., Brackney E.L. 24-h periodicity and audiogenic convulsions in I mice of various ages. Proc Soc Exp Biol (NY). 88:1955;169-173.
25. Halberg F., Jacobson E., Wadsworth G., Bittner J.J. Audiogenic abnormality spectra, 24-h periodicity and lighting. Science. 128:1958;657-658.
26. Halberg F. Temporal coordination of physiologic function. Cold Spring Harb Symp Quant Biol. 25:1960;289-310. See discussion of LD50.
27. Halberg F., Haus E., Cardoso S.S., Scheving L.E., Kühl J.F.W., Shiotsuka R., et al. Toward a chronotherapy of neoplasia: tolerance of treatment depends upon host rhythms. Experientia (Basel). 29:1973;909-934.
28. Haus E., Halberg F. 24-h rhythm in susceptibility of C mice to a toxic dose of ethanol. J Appl Physiol. 14:1959;878-880.
29. Halberg F. Symposium on "some current research methods and results with special reference to the central nervous system". Physiopathologic approach. Amer J Ment Defic. 65:1960;156-171.
30. Halberg F., Stephens A.N. Susceptibility to ouabain and physiologic circadian periodicity. Proc Minn Acad Sci. 27:1959;139-143.
31. Halberg F., Spink W.W., Albrecht P.G., Gully R.J. Resistance of mice to brucella somatic antigen, 24-h periodicity and the adrenals. J Clin Endocrinol. 15:1955;887.
32. Halberg F., Johnson E.A., Brown B.W., Bittner J.J. Susceptibility rhythm to E. coli endotoxin and bioassay. Proc Soc Exp Biol (NY). 103:1960;142-144.
33. Halberg F. Physiologic 24-h rhythms: a determinant of response to environmental agents. Schaefer K.E. Man's dependence on the earthly atmosphere. 1962;48-98 Macmillan, New York.
34. Haus E. Periodicity in response and susceptibility to environmental stimuli. Ann NY Acad Sci. 117:1964;281-291.
35. Scheving L.E. The dimension of time in biology and medicine: chronobiology. Endeavour. 35:1976;66-72.
36. Pauly J.E. Chronobiology: anatomy in time. Am J Anat. 168:1983;365-388.
37. Touitou Y., Haus E. Biological rhythms in clinical and laboratory medicine. 1992;Springer-Verlag, Berlin.
38. Raab F.J. II. Automatic ambulatory monitoring of circadian blood pressure and heart rate variations associated with periodontal therapy. March 1992;University of Minnesota. M.S. Thesis 88 p and appendix.
39. Raab F.J., Schaffer E.M., Guillaume-Cornélissen G., Halberg F. Interpreting vital sign profiles for maximizing patient safety during dental visits. JADA. 129:1998;461-469.
40. Halberg F., Cornélissen G., Halberg E., Halberg J., Delmore P., Shinoda M., et al. Chronobiology of human blood pressure. 4th:1988;. Medtronic continuing medical education seminars 242. p.
41. Halberg F., Kausz E., Winter Y., Wu J., März W., Cornélissen G. Circadian rhythmic response in cold pressor test. J Minn Acad Sci. 51:1986;14.
42. Halberg F., Breus T.K., Cornélissen G., Bingham C., Hillman D.C., Rigatuso J., et al. Chronobiology in space. University of Minnesota/Medtronic Chronobiology Seminar Series No. 1 21 p 70 figures:December 1991.
43. Halberg F., Cornélissen G., Otsuka K., Watanabe Y., Katinas G.S., Burioka N., et al. International BIOCOS study group. Cross-spectrally coherent ~10.5- and 21-year biological and physical cycles, magnetic storms and myocardial infarctions. Neuroendocrinol Lett. 21:2000;233-258.
44. Cornélissen G., Halberg F., Breus T., Syutkina E.V., Baevsky R., Weydahl A., et al. Non-photic solar associations of heart rate variability and myocardial infarction. J Atmos Solar Terr Phys. 64:2002;707-720.
45. Günther R., Herold M., Halberg E., Halberg F. Circadian placebo and ACTH effects on urinary cortisol in arthritics. Peptides. 1:1980;387-390.
46. Cornélissen G., Halberg F., Prikryl P., Dankova E., Siegelova J., Dusek J. Prophylactic aspirin treatment: the merits of timing. J Am Med Assn. 266:1991;3128-3129.
47. Prikryl P., Siegelova J., Cornélissen G., Dusek J., Dankova E., Fiser B., et al. Chronotherapeutic pilot on six persons may guide tests on thousands: toward a circadian optimization of prophylactic treatment with daily low-dose aspirin. University of Minnesota/Medtronic Chronobiology Seminar Series No. 3 4 p 4 figures:December 1991.
48. Baciu I., Cornélissen G., Olteanu A., Halberg F. Chrono-meta-analysis of circadian phagocytosis rhythms in blood of guinea pigs on two different lighting regimens. Chronobiologia. 21:1994;307-310.
49. Szabo I., Kovats T.G., Halberg F. Circadian rhythm in murine reticuloendothelial function. Chronobiologia. 5:1978;137-143.
50. Halberg F. Chronopharmacology and chronotherapy. Carpenter D.O. Cellular pacemakers. 1982;261-297 John Wiley and Sons Inc, New York.
51. Reindl K., Falliers C., Halberg F., Chai H., Hillman D., Nelson W. Circadian acrophases in peak expiratory flow rate and urinary electrolyte excretion of asthmatic children: phase-shifting of rhythms by prednisone given in different circadian system phases. Rass Neurol Veg. 23:1969;5-26.
52. Halberg E., Halberg F. Chronobiologic study design in everyday life, clinic and laboratory. Chronobiologia. 7:1980;95-120.
53. Cornélissen G., Halberg F., Perfetto F., Tarquini R., Maggioni C., Wetterberg L. Melatonin involvement in cancer: methodological considerations. Bartsch C., Bartsch H., Blask D.E., Cardinali D.P., Hrushesky W.J.M., Mecke W. The pineal gland and cancer: neuroimmunoendocrine mechanisms in malignancy. 2000;117-149 Springer, Heidelberg.
54. Langevin T., Hrushesky W., Sanchez S., Halberg F. Melatonin (M) modulates survival of CD2F1 mice with L1210 leukemia. Chronobiologia. 10:1983;173-174.
55. Sánchez de la Peña S. The feedsideward of cephalo-adrenal immune interactions. Chronobiologia. 20:1993;1-52.
56. Wrba H., Dutter A., Sanchez de la Peña S., Cornélissen G., Halberg F. Secular or circadian effects of placebo and melatonin on murine breast cancer? Prog Clin Biol Res. 341A:1990;31-40.
57. Selye H. The general adaptation syndrome and the diseases of adaptation. J Clin Endocrinol. 6:1946;117-230.
58. Selye H. The stress of life. 1951;McGraw-Hill, New York.
59. Selye H. Stress without distress. 1974;Lippincott, Philadelphia.
60. Spector N.H. Rambunctious remarks: perspectives in research on cancer, aging, and immunity. Ann NY Acad Sci. 521:1988;323-336.
61. Bernard C. Leçons sur les phénomènes de la vie communs aux animaux et aux végétaux. 1885;J.B. Bailliere, Paris.
62. Cannon W.B. The wisdom of the body. 1932;W.W. Norton, New York.
63. Halberg F., Barnum C.P., Silber R.H., Bittner J.J. 24-h rhythms at several levels of integration in mice on different lighting regimens. Proc Soc Exp Biol (NY). 97:1958;897-900.
64. Halberg F., Halberg E., Barnum C.P., Bittner J.J. Physiologic 24-h periodicity in human beings and mice, the lighting regimen and daily routine. Withrow R.B. Photoperiodism and related phenomena in plants and animals. 1959;803-878 AAAS, Washington (DC). Ed. Publ. No. 55.
65. Webster's Third New International Dictionary. 1965;2662 Mass.: G. & C. Merriam, Springfield.
66. Cornélissen G., Prikryl P., Katinas G., Dusek J., Homolka P., et al. Chronomics complement genomics in Brno. What Johann Gregor Mendel wished, Jarmilka Siegelova accomplished: broadening system times and transdisciplinary time horizons. Halberg F., Kenner T., Fiser B. Proceedings, Symposium: The Importance of Chronobiology in Diagnosing and Therapy of Internal Diseases. 10-13 January 2002;7-56 Masaryk University, Brno. Faculty of Medicine, Masaryk University, Brno, Czech Republic 2002.
67. Sothern R.B., Halberg F. Longitudinal human multifrequency structure of blood pressure self-measured for over two decades. Proceedings of the Second Annual IEEE Symposium on Computer-Based Medical Systems, Minneapolis, 26-27 June 1989:1989;288-294 Computer Society Press, Washington (DC).
68. Sothern R.B., Katinas G., Cornélissen G., Halberg F. Moving spectra of circannual variation in normotensive diastolic blood pressure: Part I. Abstract 17 Proceedings of the Third International Symposium: Workshop on Chronoastrobiology and Chronotherapy Eriguchi M. Research Center for Advanced Science and Technology. 9 November 2002;University of Tokyo.
69. Watanabe Y., Cornélissen G., Sothern R.B., Nikityuk B., Bingham C., Grafe A., et al. Numerical counterparts to sunspot cycles in human blood pressure and heart rate variability. Proceedings of the Third International Symposium of Chronobiology and Chronomedicine, Kunming, China, 7-12 October 1998. 1998;145 Chinese Society for Chronobiology and Chronomedicine, Chengdu, China.
70. Ingle D.J. The role of the adrenal cortex in homeostasis. J Endocrinol. 8:1952;xxiii-xxxvii.
71. Ratajczak H.V., Lange R.W., Sothern R.B., Hagen K.L., Vecsei P., Wu J.Y., et al. Surgical influence on murine immunity and tumor growth: relationship of body temperature and hormones with splenocytes. Proc Soc Exp Biol M. 199:1992;432-440.
72. Halberg J., Halberg E., Hayes D.K., Smith R.D., Halberg F., Delea C.S., et al. Schedule shifts, life quality and quantity modeled by murine blood pressure elevation and arthropod lifespan. Int J Chronobiol. 7:1980;17-64.
73. Kumagai Y., Shiga T., Sunaga K., Cornélissen G., Ebihara A., Halberg F. Usefulness of circadian amplitude of blood pressure in predicting hypertensive cardiac involvement. Chronobiologia. 19:1992;43-58.
74. Wetterberg L., Halberg F., Halberg E., Haus E., Kawasaki T., Ueno M., et al. Circadian characteristics of urinary melatonin from clinically healthy women at different civilization disease risk. Acta Med Scand. 220:1986;71-81.
75. Tarquini B., Cornélissen G., Perfetto F., Tarquini R., Halberg F. Chronome assessment of circulating melatonin in humans. In Vivo. 11:1997;473-484.
76. Ingle D.J. Parameters of metabolic problems. Recent Prog Horm Res. 6:1951;159-194.
77. Ingle D.J., Prestrud M.C., Nezamis J.E. Effects of administering large doses of cortisone acetate to normal rats. Am J Physiol. 166:1951;171-175.
78. Sanchez de la Peña S, Gonzalez C, Cornélissen G, Halberg F. Chronomics: time structure (chronome) of blood pressure and heart rate in health and diabetes. Abstract 26, Second International Symposium: workshop on Chronoastrobiology and Chronotherapy, Tokyo Kasei University, Tokyo, Japan, November 2001, 2 p.
79. Watanabe Y., Cornélissen G., Halberg F., Bingham C., Siegelova J., Otsuka K., et al. Incidence pattern and treatment of a clinical entity, overswinging or circadian hyperamplitudetension (CHAT). Scr Medica (Brno). 70:1997;245-261.
80. Halberg F. Some correlations between chemical structure and maximal eosinopenia in adrenalectomized and hypophysectomized mice. J Pharmacol Exp Ther. 106:1952;135-149.
81. Pincus G. A diurnal rhythm in the excretion of urinary ketosteroids by young men. J Clin Endocrinol. 3:1943;195-199.
82. Bernard C. De la diversité des animaux soumis à l'expérimentation. De la variabilité des conditions organiques dans lesquelles ils s'offrent à l'expérimentateur. J Anat Physiol normales et pathologiques de l'homme et des animaux. 2:1865;497-506.
83. Halberg F. Claude Bernard, referring to an "extreme variability of the internal milieu" Grande F., Visscher M.B. Claude Bernard and experimental medicine. 1967;193-210 Mass Schenkman, Cambridge.
84. Halberg F. Organisms as circadian systems; temporal analysis of their physiologic and pathologic reponses, including injury and death. Symposium on Medical Aspects of Stress in the Military Climate, Walter Reed Army Institute of Research (Col. William D. Tigertt, Medical Corps, Director and Commandant), Walter Reed Army Medical Center (Maj. Gen. A.L. Tynes, Medical Corps, Commanding), Washington (DC), 22-4 April 1964. US Government Printing Office; 1965-77B-714; 1965. p. 1-36.
85. Wilder J. Stimulus and response: the law of initial value. 1967;John Wright & Sons Ltd, Bristol.
86. Galton F. Family likeliness in stature. R Soc Lond Proc. 40:1886;42-63. [supplemented with an appendix by Hamilton Dickson JD on p. 63-72].
87. Good I.J. Fallacies statistical. Kruskal W.H., Tamur J.M. International encyclopedia of statistics. 1978;Free Press, New York.
88. Senn S.J., Brown R.A. Estimating treatment effects in clinical trials subject to regression to the mean. Biometrics. 41:1985;555-560.
89. Dalton A.J., Selye H. Blood picture during alarm reaction. Folia Hematol. 62:1939;397-407.
90. Halberg F., Visscher M.B. Regular diurnal physiological variation in eosinophil levels in five stocks of mice. Proc Soc Exp Biol (NY). 75:1950;846-847.
91. Panzenhagen H., Speirs R. Effect of horse serum, adrenal hormones, and histamine on the number of eosinophils in the blood and peritoneal fluid of mice. Blood. 8:1953;536-544.
92. Halberg F. Changes in eosinophil count of mice with venisections repeated at intervals of several days. Proc Soc Exp Biol (NY). 82:1953;160-162.
93. Halberg F., Visscher M.B., Bittner J.J. Relation of visual factors to eosinophil rhythm in mice. Am J Physiol. 179:1954;229-235.
94. Halberg F. Physiologic 24-h periodicity; general and procedural considerations with reference to the adrenal cycle. Z. Vitamin-, Hormon-u Fermentforsch. 10:1959;225-296.
95. Jordan V.H., Wagner H., Frohlich U. Rhythmusbildung und Ausgangswert. Zschr Physiother Jg. 30:1978;147-155.
96. Halberg F. Quo vadis basic and clinical chronobiology: promise for health maintenance. Am J Anat. 168:1983;543-594.
97. Dérer L. Rhythm and proliferation with special reference to the six-day rhythm of blood leukocyte count. Neoplasma. 7:1960;117-134.
98. Halberg F., Engeli M., Hamburger C., Hillman D. Spectral resolution of low-frequency, small-amplitude rhythms in excreted 17-ketosteroid; probable androgen induced circaseptan desychronization. Acta Endocrinol (Kbh). 50:(Suppl 103):1965;5-54.
99. Hildebrandt G., Geyer F. Adaptive significance of circadian reactive periods. J Interdiscipl Cycle Res. 15:1984;109-117.
100. Halberg F. The week in phylogeny and ontogeny: opportunities for oncology. In Vivo. 9:1995;269-278.
101. Halberg F., Marques N., Cornélissen G., Bingham C., Sanchez de la Peña S., Halberg J., et al. Circaseptan biologic time structure reviewed in the light of contributions by Laurence K. Cutkomp and Ladislav Dérer. Acta Entomol Bohemoslov. 87:1990;1-29.
102. Halberg F., Cornélissen G., Sothern R.B., Wallach L.A., Halberg E., Ahlgren A., et al. International geographic studies of oncological interest on chronobiological variables. Kaiser H. Neoplasms-comparative pathology of growth in animals, plants and man. 1981;553-596 Williams and Wilkins, Baltimore.
103. Sundararaj B.I., Vasal S., Halberg F. Circannual rhythmic ovarian recrudescence in the catfish Heteropneustes fossilis (Bloch). Proceedings of the Eighth IUPHAR Congress and Sat. Symposia, Nagasaki, July 27-28, 1981 Takahashi R., Halberg F., Walker C. Toward Chronopharmacology. 1982;319-337 Pergamon Press, Oxford/New York.
104. Halberg F., Lagoguey J.M., Reinberg A. Human circannual rhythms in a broad spectral structure. Int J Chronobiol. 8:1983;225-268.
105. Halberg F., Cornélissen G., Katinas G., Appenzeller O., Otsuka K., Sothern R.B., et al. System times and time horizons for biospheric near-matches of primarily non-photic environmental cycles. Biomed Pharmacother. 56:(Suppl 2):2002;266s-272s.
106. Fernandes G., Carandente F., Halberg E., Halberg F., Good R.A. Circadian rhythm in activity of lympholytic natural killer cell activity from spleens of Fischer rats. J Immunol. 123:1979;622-625.
107. Williams R.M., Kraus L.J., Inbar M., Dubey D.P., Yunis E.J., Halberg F. Circadian bioperiodicity of natural killer cell activity in human blood (individually assessed). Walker C.A., Winget C.M., Soliman K.F.A. Chronopharmacology and chronotherapeutics. 1981;269-273 Florida A&M University Foundation, Tallahassee, Florida.
108. Gatti G., Del Ponte D., Cavallo R., Sartori M.L., Salvadori A., Carignola R., et al. Circadian changes in human natural killer cell activity. Prog Clin Biol Res. 227A:1987;399-409.
109. Halberg F., Cornélissen G., Kopher R., Choromanski L., Eggen D., Otsuka K., et al. Chronobiologic blood pressure and ECG assessment by computer in obstetrics, neonatology, cardiology and family practice. Proceedings of the Second World Symposium Computers in the Care of the Mother, Fetus and Newborn, Kyoto, Japan, 23-26 October 1989 Maeda K., Hogaki M., Nakano H. Computers and perinatal medicine. 1990;3-18 Excerpta Medica, Amsterdam.
110. Halberg F., Cornélissen G., Sonkowsky R.P., Lanzoni C., Galvagno A., Montalbini M., et al. Chrononursing (chronutrics), psychiatry and language. New Trends Exp Clin Psych. 14:1998;15-26.
111. Sanchez de la Peña S., Halberg F., Galvagno A., Montalbini M., Follini S., Wu J., et al. Circadian and circaseptan (about-7-day) free-running physiologic rhythms of a woman in social isolation. Proceedings of the Second Annual IEEE Symposium on Computer-Based Medical Systems, Minneapolis, 26-27 June 1989:1989;273-278 Computer Society Press, Washington (DC).
112. Halberg F., Katinas G.S., Chiba Y., Garcia Sainz M., Kovats T.G., Künkel H., et al. Chronobiologic glossary of the international society for the study of biologic rhythms. Int J Chronobiol. 1:1973;31-63.
113. Halberg F. Physiologic considerations underlying rhythmometry, with special reference to emotional illness. Symposium on Biological Cycles and Psychiatry. Symposium Bel-Air III. 1968;73-126 Masson et Cie, Geneva.
114. Halberg F., Carandente F., Cornélissen G., Katinas G.S. Glossary of chronobiology. Chronobiologia. 4:(Suppl 1):1977;189.
115. Halberg F., Halberg E. Appendix: terms for methods and facts in chronopharmacology. Proceedings of the Eighth IUPHAR Congress and Sat. Symposia, Nagasaki, 27-28 July 1981 Takahashi R., Halberg F., Walker C. Toward chronopharmacology. 1982;391-423 Pergamon Press, Oxford/New York.
116. Carandente F. Glossary of chronobiology: update. Chronobiologia. 11:1984;313-322.
117. Sonkowsky R., Halberg F. Nomina chronobiologica. Proceedings of the Third International Symposium on Social Diseases and Chronobiology, Florence, 29 November 1986 Tarquini B. Social diseases and chronobiology. 1987;487-494 Società Editrice Esculapio, Bologna.
118. Cornélissen G., Bakken E., Delmore P., Orth-Gomér K., Åkerstedt T., Carandente O., et al. From various kinds of heart rate variability to chronocardiology. Am J Cardiol. 66:1990;863-868.
119. Halberg F., Cornélissen G., Katinas G., Hillman D., Schwartzkopff O. Season's appreciations 2000: chronomics complement, among many other fields, genomics and proteomics. Neuroendocrinol Lett. 22:2001;53-73.
120. Hawking S.W. A brief history of time: from the big bang to black holes. 1988;Bantam, New York.
121. Cornélissen G., Siegelova J., Halberg F. Blood pressure and heart rate dynamics during pregnancy and early extra-uterine life: methodology for a chrononeonatology. Halberg F., Kenner T., Fiser B. Proceedings, Symposium: The Importance of Chronobiology in Diagnosing and Therapy of Internal Diseases. 2002;58-96 Masaryk University, Brno. Faculty of Medicine, Masaryk University, Brno, Czech Republic, 10-13 January 2002.
122. Cornélissen G., Halberg F., Syutkina E.V., Watanabe Y., Otsuka K., Maggioni C., et al. From Theodor Hellbrügge to pre-habilitation, chronopediatrics and chronomics. Int J Prenat Perinat Psychol M. 12:2000;275-303.
123. Carroll L. The Annotated Alice: Alice's Adventures in Wonderland and Through the Looking Glass. 1960;New York: Bramhall House. (Tenniel J, illustrations; Gardner M, introduction and notes).
124. Stadick A., Bryans R., Halberg E., Halberg F. Circadian cardiovascular rhythms during recumbency. Proceedings of the Third International Symposium on Social Diseases and Chronobiology, Florence, 29 November 1986 Tarquini B. Social diseases and chronobiology. 1987;191-200 Società Editrice Esculapio, Bologna.
125. Speransky A.D. A basis for the theory of medicine. 1935;International Publishers, New York.
126. Fessard A. Propriétés rythmiques de la matière vivante. 1936;Hermann, Paris.
127. Halberg F., Frank G., Harner R., Matthews J., Aaker H., Gravem H., et al. The adrenal cycle in men on different schedules of motor and mental activity. Experientia (Basel). 17:1961;282.
128. Reinberg A., Ghata J., Halberg F., Gervais P., Abulker C., Dupont J., et al. Rythmes circadiens du pouls, de la pression artérielle, des excrétions urinaires en 17-hydroxycorticostéroïdes, catécholamines et potassium chez l'homme adulte sain, actif et au repos. Ann Endocrinol (Paris). 31:1970;277-287.
129. Lange C.G., James W. The emotions. 1922;Williams and Wilkins, Baltimore.
130. Levine H., Saltzman W., Yankaskas J., Halberg F. Circadian state-dependent effect of exercise upon blood pressure in clinically healthy men. Chronobiologia. 4:1977;129-130.
131. Halberg F. Some aspects of the chronobiology of nutrition: more work is needed on "when to eat" J Nutr. 119:1989;333-343.
132. Halberg F., Cornélissen G., Halberg E., Mainardi G., Hermida R.C., Tarquini B., et al. Toward chronobiologic optimization of nutrition for cancer treatment and broad disease prevention. Roche A.F. The role of nutrients in cancer treatment, Report of the Ninth Ross Conference on Medical Research. 1991;2-9 Ross Laboratories, Columbus (OH).
133. Halberg F., Haus E., Cornélissen G. From biologic rhythms to chronomes relevant for nutrition. Marriott B.M. Not eating enough: overcoming underconsumption of military operational rations. 1995;361-372 National Academy Press, Washington (DC).
134. Smolensky M., Halberg F., Sargent F. II. Chronobiology of the life sequence. Itoh S., Ogata K., Yoshimura H. Advances in climatic physiology. 1972;281-318 Igaku Shoin Ltd, Tokyo.
135. Reinberg A., Gervais P., Halberg F., Gaultier M., Roynette N., Abulker C., et al. Mortalité des adultes: rythmes circadiens et circannuels dans un hôpital parisien et en France. Nouv Presse méd. 2:1973;289-294.
136. Halberg F. Laboratory techniques and rhythmometry. Mills J.N. Biological aspects of circadian rhythms. 1973;1-26 Plenum Press, London/New York.
137. Cornélissen G., Breus T.K., Bingham C., Zaslavskaya R., Varshitsky M., Mirsky B., et al., International Womb-to-Tomb Chronome Initiative Group. Beyond circadian chronorisk: worldwide circaseptan- circasemiseptan patterns of myocardial infarctions, other vascular events, and emergencies. Chronobiologia. 20:1993;87-115.
138. Nintcheu-Fata S, Katinas G, Halberg F, Cornélissen G, Tolstykh V, Michael HN, et al. Chronomics of tree rings for chronoastrobiology and beyond 2003;57. In press.
139. Halberg F, Katinas G, Cornélissen G, Otsuka K, Tarquini R, Perfetto F, et al. Transient circadian hyper-amplitude-tension (CHAT) may be intermittent: two case reports 2003;57. In press.
140. Benetato G., Baciu I., Vlad L. Zentralnervensystem und Abwehrfunktion. Die Rolle der hypothalamischen vegetativen Zentren bei der Phagozytentatigkeit. Schweiz med Wochenschr. 75:1945;702-712.
141. Benetato G., Oprisiu C., Baciu I. Système nerveux central et phagocytose (contribution expérimentale grâce à la méthode de la tête isolée). J Phys (Paris). 39:1947;191-197.
142. Baciu I. The role of the central nervous system in activation of phagocytosis. 1946;University of Medicine, Cluj. Thesis.
143. Baciu I., Ivanof A. The role of hypothalamic centers in the immune specific response. Rev Roum Morph Embryol Phys. 21:1984;251-259.
144. Baciu I. Nervous control of the phagocytic system. Int J Neurosci. 41:1988;127-141.
145. Baciu I., Olteanu A., Prodan T., Baiescu M., Vaida A. Changes of phagocytic biological rhythm by reduction of circadian times and by influences upon hypothalamus. Int J Neurosci. 41:1988;143-153.
146. Baciu I., Maghiar A., Teodorescu A., Junie M. The effects of electroconvulsant shocks on phagocytic activity and on phagocytic response. Rom J Phys. 32:(1-4):1995;161-168.
147. Baciu I., Felegean A., Maghiar T.T., Hozan C., Albu M. Effects of thymectomy on blood neutrophils phagocytic activity and phagocytic response in mice. Rom J Phys. 33:(1-4):1996;75-81.
148. Felegean A., Junie M., Baciu I. Effects of the electrolytic damage of the arcuate nucleus on the blood neutrophils phagocytic activity and phagocytic response. Rom J Phys. 34:(1-4):1997;75-82.
149. Hriscu M., Saulea G., Vidrascu N., Baciu I. Effects of monosodium glutamate on blood neutrophils phagocytic activity and phagocytic response in mice. Rom J Phys. 34:(1-4):1997;95-101.
150. Hriscu M., Saulea G., Vidrascu N., Baciu I. Circadian rhythm of phagocytosis in mice. Rom J Phys. 35:(3-4):1998;315-319.
151. Baciu I., Hriscu M., Saulea G. Hypothalamic mechanisms of immunity. Int J Neurosci. 113:2003;259-277.
152. Halberg F., Breus T.K., Cornélissen G., Bingham C., Hillman D.C., Rigatuso J., et al. Chronobiology in space. Keynote, 37th Ann. Mtg. Japan Soc. for Aerospace and Environmental Medicine, Nagoya, Japan, 8-9 November, 1991 University of Minnesota/Medtronic Chronobiology Seminar Series, No. 1 21 p 70 figures:December 1991.
153. Halberg F., Cornélissen G., Otsuka K., Watanabe Y., Katinas G.S., Burioka N., et al. Cross-spectrally coherent ~10.5- and 21-year biological and physical cycles, magnetic storms and myocardial infarctions. Neuroendocrinol Lett. 21:2000;233-258.
154. Cornélissen G., Halberg F., Breus T., Syutkina E.V., Baevsky R., Weydahl A., et al. Non-photic solar associations of heart rate variability and myocardial infarction. J Atmos Solar-Terr Phys. 64:2002;707-720.
155. Halberg F., Barnum C.P., Silber R.H., Bittner J.J. 24-h rhythms at several levels of integration in mice on different lighting regimens. Proc Soc exp Biol (NY). 97:1958;897-900.
156. Halberg F, Sanchez S, Nelson W. Rhythm scrambling and tumorigenesis in CD2F1 mice. In: Tarquini B, Vergassola R, editors. Third International Symposium, Social Diseases and Chronobiology, Florence, November 29, 1986. p. 59-61.
157. Carlebach R., Ashkenazi I.E. Temporal disorder: therapeutic
158. Kort W.J., Zondervan P.E., Hulsman L.O., Weijma I.M., Westbroek D.L. Light-dark-shift stress, with special reference to spontaneous tumor incidence in female BN rats. J Nat Cancer Inst. 76:1986;439-446.
159. Hayes D.K., Halberg F., Cornélissen G., Shankaraiah K. Frequency response of the face fly, Musca autumnalis, to lighting schedule shifts at varied intervals. Ann Entomol Soc Am. 79:1986;317-323.
160. Halberg F., Jacobson E., Wadsworth G., Bittner J.J. Audiogenic abnormality spectra, 24-h periodicity and lighting. Science. 128:1958;657-658.
161. Cornélissen G., Halberg F., Tarquini B. Circadian range no substitute for amplitude in assessing high blood pressure (BP) risk. J Minn Acad Sci. 51:1986;14.
162. Raab F.J. II: Automatic ambulatory monitoring of circadian blood pressure and heart rate variations associated with periodontal therapy. March 1992;University of Minnesota. M.S. Thesis 88 p and tables and figures.
163. Halberg F., Cornélissen G. Resolution from a meeting of the International Society for Research on Civilization Diseases and the Environment (New SIRMCE Confederation), Brussels, Belgium, March 17-18, 1995. Fairy tale or reality? 1994. Medtronic Chronobiology Seminar No. 8 18 figures. Available from URL [accessed].
164. Halberg F., Cornélissen G., Otsuka K., Schwartzkopff O., Halberg J., Bakken E.E. Chronomics. Biomed Pharmacother. 55:(Suppl 1):2001;153-190.
165. Halberg F. Quo vadis basic and clinical chronobiology: promise for health maintenance. Am J Anat. 168:1983;543-594.