Quantitative analysis of dipeptidyl peptidase inhibitor P32/98 and its main metabolite in rat, dog, mouse, monkey, human plasma and human urine using liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic evaluation

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 796, Issue 2, 2003, Pages 401-411

  Meyer, Antje ^a   Gourinchas, Elisabeth ^b   Girault, Jacques ^b   Demuth, Hans Ulrich ^a  

^a PROBIODRUG AG   (Germany)

^b PAREXEL INTERNATIONAL   (United States)

Author keywords

Dipeptidyl peptidases; DP IV inhibitor; Pharmacokinetics

Indexed keywords

DRUG PRODUCTS; ENZYMES; ION EXCHANGE; IONIZATION; PHARMACOKINETICS; POLYPEPTIDES; POSITIVE IONS;

ANTIDIABETIC DRUGS;

LIQUID CHROMATOGRAPHY;

ANTIDIABETIC AGENT; BIS(2 AMINO 3 METHYLPENTANOIC 1,3 THIAZOLIDIDE)FUMARATE; BIS(2 AMINO 3 METHYLPENTANOIC 1,3 THIAZOLIDINE S OXIDE)FUMARATE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; FUMARIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG URINE LEVEL; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MONKEY; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RAT; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

CANIS FAMILIARIS;

EID: 0142195994     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2003.08.028     Document Type: Article

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