Matched case-control study to evaluate risk factors for hyperlactataemia in HIV patients on antiretroviral therapy

HIV Medicine

Volumn 4, Issue 4, 2003, Pages 311-314

  Datta, D ^a   Moyle, G ^a   Mandalia, S ^a   Gazzard, B ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

ART; Hyperlactataemia

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; CHOLESTEROL; DIDANOSINE; EFAVIRENZ; GLUCOSE; INDINAVIR; LACTIC ACID; LAMIVUDINE; NELFINAVIR; NEVIRAPINE; RITONAVIR; SAQUINAVIR; STAVUDINE; ZIDOVUDINE;

ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG USE; FEMALE; GENDER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERLACTATEMIA; LACTIC ACIDOSIS; LOGISTIC REGRESSION ANALYSIS; MALE; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL;

ACIDOSIS, LACTIC; ANTI-HIV AGENTS; CASE-CONTROL STUDIES; DIDANOSINE; FEMALE; HIV INFECTIONS; HUMANS; LACTIC ACID; MALE; MULTIVARIATE ANALYSIS; RISK FACTORS; SEX FACTORS; STAVUDINE;

EID: 0142186265     PISSN: 14642662     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-1293.2003.00164.x     Document Type: Article

References (6)

1. Moyle GJ, Datta D, Mandalia S et al. Hyperlactataemia and lactic acidosis during antiretroviral therapy: relevance, reproducibility and possible risk factors. AIDS 2002; 16: 1341-1349.
2. John M, Moore CB, James IR et al. Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy. AIDS 2001; 15: 717-723.
3. Sundar K, Suarez M, Banogon PE et al. Zidovudine-induced fatal lactic acidosis and hepatic failure in patients with acquired immunodeficiency syndrome: report of two patients and review of the literature. Crit Care Med 1997; 25: 1425-1430.
4. Brinkman K, ter Hofstede HJ. Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: lactic acidosis, risk factors and therapeutic options. AIDS Rev 1999; 1: 141-148.
5. Moyle G. Mitochondrial toxicity hypothesis for lipoatrophy: a refutation. AIDS 2001; 15: 413-415.
6. Brinkman K. Management of hyperlactatemia: no need for routine lactate measurements. AIDS 2001; 15: 795-797.