Comparison of efficacy of efavirenz and nevirapine: Lessons learned for cohort analysis in light of the 2NN study

HIV Clinical Trials

Volumn 4, Issue 5, 2003, Pages 358-360

  Keiser, Philip ^a,c   Nassar, Naiel ^a   Yazdani, Beena ^a   Armas, Laura ^a   Moreno, Sylvia ^b  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b PARKLAND HEALTH AND HOSPITAL SYSTEM   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFAVIRENZ; LAMIVUDINE; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE;

CLINICAL TRIAL; COHORT ANALYSIS; DRUG EFFICACY; DRUG RESPONSE; FOLLOW UP; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; NONBIOLOGICAL MODEL; PRIORITY JOURNAL; TREATMENT FAILURE;

ANTI-HIV AGENTS; COHORT STUDIES; HIV INFECTIONS; HUMANS; NEVIRAPINE; OXAZINES; RANDOMIZED CONTROLLED TRIALS; RESEARCH DESIGN;

EID: 0142186211     PISSN: 15284336     EISSN: None     Source Type: Journal    
DOI: 10.1310/7G2E-5PPL-YB76-PBM4     Document Type: Letter

References (8)

1. Keiser P, Nassar N, White C, Koen G, Moreno S. Comparison of nevirapine- and efavirenz-containing antiretroviral regimens in antiretroviral-naïve patients: a cohort study. HIV Clin Trials. 2002;3(4):296-303.
2. Phillips AN, et al. Viral load outcome of non-nucleoside reverse transcriptase inhibitor regimens for 2203 mainly antiretroviral-experienced patients. AIDS. 2001:15:2385-2395.
3. Matthews GV, et al. Virological suppression at 6 months is related to choice of initial regimen in antiretroviral-naive patients: a cohort study. AIDS. 2002:16:53-61.
4. Cozzi-Lepri A, et al. Virologic and immunologic response to regimens containing nevirapine or efavirenz in combination with 2 nucleoside analogues in the Italian Cohort Naïve Antiretrovirals (IcoNA) Study. J Infect Dis. 2002;185:1062-1069.
5. van Leth F, et al. Results of the 2NN Study: a randomized comparative trial of first-line antiretroviral therapy with regimens containing either nevirapine alone, efavirenz alone or both drugs combined, together with stavudine and lamivudine. Paper presented at: 10th, CROI; 2003.
6. Van Leeowen R. Design of 2NN: a large scale, randomized comparison of efavirenz and nevirapine. Presented at: 6th ICDTHIV; 2002; Glasgow. Poster 34.
7. Phillips AN, et al. Use of observational databases, to evaluate the effectiveness of antiretroviral therapy for HIV infection: comparison of cohort studies with randomized trials. EuroSIDA, the French Hospital Database on HIV and the Swiss HIV Cohort Study Groups. AIDS. 1999:13:2075-2082.
8. Pocock SJ and Elbourne DR. Randomized trials or observational tribulations. N Engl J Med. 2000;342:1907-1909.