Functional genomics in Xenopus laevis: Towards transgene-driven RNA interference and cell-specific transgene expression

Current Genomics

Volumn 4, Issue 8, 2003, Pages 699-711

  Dirks, Ron P H ^a   Bouw, Gerrit ^a   Huizen, Rick Van ^a   Jansen, Eric J R ^a   Martens, Gerard J M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

dsRNA; Intermediate pituitary cells; p24; POMC promoter; RNA interference; Secretory pathway; Transgenesis

Indexed keywords

CELL PROTEIN; GAG PROTEIN; GREEN FLUORESCENT PROTEIN; PROOPIOMELANOCORTIN; RNA; RNA POLYMERASE II;

CELL CYCLE; CELL DIFFERENTIATION; CELL MANIPULATION; CELL SPECIFICITY; CLINICAL PROTOCOL; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE TARGETING; GENETIC ANALYSIS; GENOMICS; HYPOPHYSIS CELL; MELANOPHORE; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN TRANSPORT; RELIABILITY; REVIEW; TISSUE SPECIFICITY; TRANSGENE; XENOPUS LAEVIS;

AMPHIBIA; MELANOPHORA; REPTILIA; VERTEBRATA; XENOPUS LAEVIS;

EID: 0142185252     PISSN: 13892029     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389202033490132     Document Type: Review

References (64)

1. Kroll, K.L. and Amaya, E. Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation. Development 1996, 122: 3173-3183.
2. Sparrow, D.B., Latinkic, B. and Mohun, T.J. A simplified method of generating transgenic Xenopus. Nucleic Acids Res. 2000, 28: E12.
3. Veenstra, G.J., Weeks, D.L. and Wolffe, A.P. Distinct roles for TBP and TBP-like factor in early embryonic gene transcription in Xenopus. Science 2000, 290: 2312-2315.
4. Heasman, J. Morpholino oligos: making sense of antisense? Dev. Biol. 2002, 243: 209-214.
5. Hamilton, A.J. and Baulcombe, D.C. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 1999, 286: 950-952.
6. Kennerdell J.R. and Carthew, R.W. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 1998, 95: 1017-1026.
7. Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E. and Mello, C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391: 806-811.
8. McManus, M.T. and Sharp, P.A. Gene silencing in mammals by small interfering RNAs. Nature Rev. Genetics 2002, 3: 737-747.
9. Dykxhoorn, D.M., Novina, C.D. and Sharp, P.A. Killing the messenger: short RNAs that silence gene expression. Nature Rev. Mol. Cell. Biol. 2003, 4: 457-467.
10. Stark, G.R., Kerr, I.M., Williams, B.R., Silverman, R.H. and Schreiber, R.D. How cells respond to interferons. Annu. Rev. Biochem. 1998, 67: 227-264.
11. Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K. and Tuschl, T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411: 494-498.
12. Nakano, H., Amemiya, S., Shiokawa, K. and Taira, M. RNA interference for the organizer-specific gene Xlim-1 in Xenopus embryos. Biochem. Biophys. Res. Commun. 2000, 274: 434-439.
13. Zhou, Y., Ching, Y.P., Kok, K.H., Kung, H.F, and Jin, D.Y. Post-transcriptional suppression of gene expression in Xenopus embryos by small interfering RNA. Nucleic Acids Res. 2002, 30: 1664-1669.
14. Oates, A.C., Bruce, A.E. and Ho, R.K. Too much interference: injection of double-stranded RNA has nonspecific effects in the zebrafish embryo. Dev. Biol. 2000, 224: 20-28.
15. Zhao, Z., Cao, Y., Li, M. and Meng, A. Double-stranded RNA injection produces nonspecific defects in zebrafish. Dev. Biol. 2001, 229: 215-223.
16. Smith, N.A., Singh, S.P., Wang, M.-B., Stoutjesdijk, P.A., Green, A.G. and Waterhouse, P.M. Total silencing by intron-spliced hairpin RNAs. Nature 2000, 407: 319-320.
17. Andreazzoli, M., Gestri, G., Angeloni, D., Menna, E. and Barsacchi, G. Role of Xrx1 in Xenopus eye and anterior brain development. Development 1999, 126: 2451-2460.
18. Brummelkamp, T.R., Bernards, R. and Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002, 296: 550-553.
19. Paddison, P.J., Caudy, A.A., Bernstein, E., Hannon, G.J. and Conklin, D.S. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 2002, 16: 948-958.
20. Xia, H., Mao, Q., Paulson, H.L. and Davidson, B.L. siRNA-mediated gene silencing in vitro and in vivo. Nat. Biotechnol. 2002, 20: 1006-1010.
21. Kunath, T., Gish, G., Lickert, H., Jones, N., Pawson, T. and Rossant, J. Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Nat. Biotechnol. 2003, 21: 559-561.
22. Knox, B.E., Schlueter, C., Sanger, B.M., Green, C.B. and Besharse, J.C. Transgene expression in Xenopus rods. FEBS Lett. 1998, 423: 117-121.
23. He, W., Lu, L., Zhang, X., El-Hodiri, H.M., Chen, C.K., Slep, K.C., Simon, M.I., Jamrich, M. and Wensel, T.G. Modules in the photoreceptor RGS9-1.Gbeta 5L GTPase-accelerating protein complex control effector coupling, GTPase acceleration, protein folding, and stability. J. Biol. Chem. 2000, 275: 37093-37100.
24. Tam, B.M., Moritz, O.L., Hurd, L.B. and Papermaster, D.S. Identification of an outer segment targeting signal in the COOH terminus of rhodopsin using transgenic Xenopus laevis. J. Cell. Biol. 2000, 151: 1369-1380.
25. Beck, C.W. and Slack, J.M. Gut specific expression using mammalian promoters in transgenic Xenopus laevis. Mech. Dev. 1999, 88: 221-227.
26. Marsh-Armstrong, N., Huang, H., Berry, D.L. and Brown, D.D. Germ-line transmission of transgenes in Xenopus laevis. Proc. Natl. Acad. Sci. USA 1999, 96: 14389-14393.
27. Offield, M.F., Hirsch, N. and Grainger, R.M. The development of Xenopus tropicalis transgenic lines and their use in studying lens developmental timing in living embryos. Development 2000, 127: 1789-1797.
28. Mani, S.S., Besharse, J.C. and Knox, B.E. Immediate upstream sequence of arrestin directs rod-specific expression in Xenopus. J. Biol. Chem. 1999, 274: 15590-15597.
29. Zhu, X., Ma, B., Babu, S., Murage, J., Knox, B.E. and Craft, C.M. Mouse cone arrestin gene characterization: promoter targets expression to cone photoreceptors. FEBS Lett. 2002, 524: 116-122.
30. Furlow, J.D. and Brown, D.D. In vitro and in vivo analysis of the regulation of a transcription factor gene by thyroid hormone during Xenopus laevis metamorphosis. Mol. Endocrinol. 1999, 13: 2076-2089.
31. Ryffel, G.U. and Lingott, A. Distinct promoter elements mediate endodermal and mesodermal expression of the HNF1alpha promoter in transgenic Xenopus. Mech. Dev. 2000, 90: 65-75.
32. Breckenridge, R.A., Mohun, T.J. and Amaya, E. A role for BMP signalling in heart looping morphogenesis in Xenopus. Dev. Biol. 2001, 232: 191-203.
33. Liu, X. and Green, C.B. A novel promoter element, photoreceptor conserved element II, directs photoreceptor-specific expression of nocturnin in Xenopus laevis. J. Biol. Chem. 2001, 276: 15146-15154.
34. Lerner, L.E., Gribanova, Y.E., Ji, M., Knox, B.E. and Farber, D.B. Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements. J. Biol. Chem. 2001, 276: 34999-35007.
35. Oofusa, K., Tooi, O., Kashiwagi, A., Kashiwagi, K., Kondo, Y., Watanabe, Y., Sawada, T., Fujikawa, K. and Yoshizato, K. Expression of thyroid hormone receptor betaA gene assayed by transgenic Xenopus laevis carrying its promoter sequences. Mol. Cell. Endocrinol. 2001, 181: 97-110.
36. Schreiber, A.M., Das, B., Huang, H., Marsh-Armstrong, N. and Brown, D.D. Diverse developmental programs of Xenopus laevis metamorphosis are inhibited by a dominant negative thyroid hormone receptor. Proc. Natl. Acad. Sci. USA 2001, 98: 10739-10744.
37. Boatright, J.H., Knox, B.E., Jones, K.M., Stodulkova, E., Nguyen, H.T., Padove, S.A., Borst, D.E. and Nickerson, J.M. Evidence of a tissue-restricting DNA regulatory element in the mouse IRBP promoter. FEBS Lett. 2001, 504: 27-30.
38. Jansen, E.J., Holling, T.M., van Herp, F. and Martens, G.J. Transgene-driven protein expression specific to the intermediate pituitary melanotrope cells of Xenopus laevis. FEBS Lett. 2002, 516: 201-207.
39. Chae, J., Zimmerman, L.B. and Grainger, R.M. Inducible control of tissue-specific transgene expression in Xenopus tropicalis transgenic lines. Mech. Dev. 2002, 117: 235-241.
40. Moritz, O.L., Peck,A. and Tam, B.M. Xenopus laevis red cone opsin and Prph2 promoters allow transgene expression in amphibian cones, or both rods and cones. Gene 2002, 298: 173- 182.
41. Asahi, H., Takase, M., Yuge, M., Matsui, K., Mori, M., Fujita, T. and Nakamura, M. Expression of FTZ-F1alpha in transgenic Xenopus embryos and oocytes. Dev. Growth Differ. 2002, 44: 509-516.
42. Kaiser, C., Thinking about p24 proteins and how transport vesicles select their cargo. Proc. Natl. Acad. Sci. USA, 2000, 97: 3783-3785.
43. Schimmoller, F., Singer-Kruger, B., Schroder, S., Kruger, U., Barlowe, C. and Riezman, H. The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi. EMBO J. 1995, 14: 1329-1339.
44. Muniz, M., Nuoffer, C., Hauri, H.P. and Riezman, H. The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles. J. Cell. Biol. 2000, 148: 925-930.
45. Belden, W.J. and Barlowe, C. Deletion of yeast p24 genes activates the unfolded protein response. Mol. Biol. Cell 2001, 12: 957-969.
46. Lavoie, C., Paiement, J., Dominguez, M., Roy, L., Dahan, S., Gushue, J.N. and Bergeron, J.J. Roles for alpha(2)p24 and COPI in Endoplasmic Reticulum Cargo Exit Site Formation. J. Cell. Biol. 1999, 146: 285-300.
47. Rojo, M., Pepperkok, R., Emery,G., Kellner, R., Stang, E., Parton, R.G. and Gruenberg, J. Involvement of the transmembrane protein p23 in biosynthetic protein transport. J. Cell. Biol. 1997, 139: 1119-1135.
48. Denzel, A., Otto, F., Girod, A., Pepperkok, R., Watson, R., Rosewell, I., Bergeron, J.J., Solari, R.C. and Owen, M.J., The p24 family member p23 is required for early embryonic development. Curr. Biol., 2000, 10: 55-58.
49. Bremser, M., Nickel, W., Schweikert, M., Ravazzola, M., Amherdt, M., Hughes, C.A., Sollner, T.H., Rothman, J.E. and Wieland, F.T. Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. Cell 1999, 96: 495-506.
50. Wen, C. and Greenwald, I. p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans. J. Cell. Biol. 1999, 145: 1165-1175.
51. Elrod Erickson, M.J. and Kaiser, C.A. Genes that control the fidelity of endoplasmic reticulum to Golgi transport identified as suppressors of vesicle budding mutations. Mol. Biol. Cell 1996, 7: 1043-1058.
52. Springer, S., Chen, E., Duden, R., Marzioch, M., Rowley, A., Hamamoto, S., Merchant, S. and Schekman, R. The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 2000, 97: 4034-4039.
53. Marzioch, M., Henthorn, D.C., Herrmann, J.M., Wilson, R., Thomas, D.Y., Bergeron, J.J., Solari, R.C. and Rowley, A. Erp1p and Erp2p, Partners for Emp24p and Erv25p in a Yeast p24 Complex. Mol. Biol. Cell 1999, 10: 1923-1938.
54. Roubos, E.W. Background adaptation by Xenopus laevis: a model for studying neuronal information processing in the pituitary pars intermedia. Comp. Biochem. Physiol. A. Physiol. 1997, 118: 533-550.
55. Holthuis, J.C., van Riel, M.C. and Martens, G.J. Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary. Biochem. J. 1995, 312 (Pt 1): 205-213.
56. Rotter, J., Kuiper, R.P., Bouw, G. and Martens, G.J., Cell-type-specific and selectively induced expression of members of the p24 family of putative cargo receptors. J. Cell Sci. 2002, 115 (Pt 5): 1049-1058.
57. Holthuis, J.C., Jansen, E.J., van Riel, M.C. and Martens, G.J. Molecular probing of the secretory pathway in peptide hormone-producing cells. J. Cell Sci. 1995, 108 (Pt 10): 3295-3305.
58. Muskens, M.W., Vissers, A.P., Mol, J.N. and Kooter, J.M. Role of inverted DNA repeats in transcriptional and post-transcriptional gene silencing. Plant Mol. Biol. 2000, 43: 243-260.
59. Matzke, M.A., Aufsatz, W., Kanno, T., Mette, M.F. and Matzke, A.J. Homology-dependent gene silencing and host defense in plants. Adv. Genet. 2002, 46: 235-275.
60. Henikoff, S., Conspiracy of silence among repeated transgenes. Bioessays 1998, 20: 532-535.
61. Dominguez, M., Dejgaard, K., Fullekrug, J., Dahan, S., Fazel, A., Paccaud, J.P., Thomas, D.Y., Bergeron, J.J. and Nilsson, T. gp251/emp24/p24 protein family members of the cis-Golgi network bind both Cop I and II coatomer. J. Cell. Biol. 1998, 140: 751-765.
62. Sohn, K., Orci, L., Ravazzola, M., Amherdt, M., Bremser, M., Lottspeich, F., Fiedler, K., Helms, J.B. and Wieland, F.T. A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding. J. Cell. Biol. 1996, 135: 1239-1248.
63. Barlowe, C. COPII and selective export from the endoplasmic reticulum. Biochim. Biophys. Acta 1998, 1404: 67-76.
64. Jackson, A.L., Bartz, S.R., Schelter, J., Kobayashi, S.V., Burchard, J., Mao, M., Li, B., Cavet, G. and Linsley, P.S. Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. 2003, 21: 635-637.