Endothelial cells express normal cellular prion protein [7]

British Journal of Haematology

Volumn 123, Issue 2, 2003, Pages 372-373

  Starke, Richard ^a   Harrison, Paul ^b   Gale, Rosemary ^a   Mackie, Ian ^a   Drummond, Olive ^c   MacGregor, Ian ^c   Machin, Samuel ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c SCOTTISH NATIONAL BLOOD TRANSFUSION SERVICE   (United Kingdom)

Author keywords

Blood plasma; Endothelium; Prion protein; PrPc

Indexed keywords

PRION PROTEIN; PROTEIN ANTIBODY;

BLOOD CELL COUNT; CELL CULTURE; CORRELATION ANALYSIS; DENSITOMETRY; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; ISOTOPE LABELING; LETTER; PLASMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; TISSUE LEVEL; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; HUMANS; PRPC PROTEINS;

EID: 0142184347     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04642.x     Document Type: Letter

References (6)

1. Barclay, G.R., Houston, E.F., Halliday, S.I., Farquhar, C.F. & Turner, M.L. (2002) Comparative analysis of normal prion protein expression on human, rodent, and ruminant blood cells by using a panel of prion antibodies. Transfusion, 42, 517-526.
2. Holada, K. & Vostal, J.G. (2000) Different levels of prion protein (PrPC) expression on hamster, mouse and human blood cells. British Journal of Haematology, 110, 472-480.
3. Simak, J., Holada, K., D'Agnillo, F., Janota, J. & Vostal, J.G. (2002) Cellular prion protein is expressed on endothelial cells and is released during apoptosis on membrane microparticles found in human plasma. Transfusion, 42, 334-342.
4. Simak, J., Holada, K. & Vostal, J.G. (2003) Expression of cellular prion protein on vascular endothelial cells: more evidence than controversies. Transfusion, 43, 680-681.
5. Sivakumaran, M. (2003) The expression of prion protein (PrPc) by endothelial cells: an in vitro culture-induced artefactual phenomenon? British Journal of Haematology, 121, 673-674.
6. Starke, R., Drummond, O., MacGregor, I., Biggerstaff, J., Gale, R., Camilleri, R., Mackie, I., Machin, S. & Harrison, P. (2002) The expression of prion protein by endothelial cells: a source of the plasma form of prion protein? British Journal of Haematology, 119, 863-873.