Accessibility of solid core tablet for dissolution in an asymmetric triple-layer matrix system

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 10, 2003, Pages 1331-1337

  Yang, Libo ^a,b   Fassihi, Reza ^a  

^a TEMPLE UNIVERSITY   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL; POLYOX; VERAPAMIL;

ALGORITHM; ARTICLE; CONTROLLED DRUG RELEASE; DISSOLUTION; DRUG DETERMINATION; DRUG DIFFUSION; DRUG EROSION; DRUG RELEASE; KINETICS; MOLECULAR WEIGHT; NONLINEAR REGRESSION ANALYSIS; PHYSICAL CHEMISTRY; POLYMERIZATION; SOLID STATE; TABLET FORMULATION; TABLET MATRIX; TABLET SURFACE; TABLET THICKNESS;

ADMINISTRATION, ORAL; CALCIUM CHANNEL BLOCKERS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; KINETICS; METHYLCELLULOSE; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; PROTEASE INHIBITORS; SOLUBILITY; TABLETS; VERAPAMIL;

EID: 0142183279     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021927     Document Type: Article

References (25)

1. Apicella, A., Cappello, B., Del Nobile, M. A., La Rontonda, M. I., Mensitieri, G., Nicolais, L. (1993) Poly(ethylene oxide) (PEO) and different molecular weight PEO blends monolithic devices for drug release. Biomaterials 14: 83-91
2. Berens, A. R., Hopfenberg, H. B. (1978) Diffusion and relaxation in glassy polymer powders: 2. Separation of diffusion and relaxation parameters. Polymer 19: 489-496
3. Bowtell, R., Sharp, J. C., Peters, A., Mansfield, P., Rajabi-Siahboomi, A. R., Davies, M. C., Melia, C. D. (1994) NMR microscopy of hydrating hydrophilic matrix pharmaceutical tablets. Magn. Reson. Imaging 12: 361-364
4. Brooke, D., Washkuhn, R. J. (1977) Zero-order drug delivery system. Theory and preliminary testing. J. Pharm. Sci. 66: 159-162
5. Buchwalter, F., Granatek, A., DeMurio, M. (1964) US Patent 3,121,044
6. Colombo, P., La Manna, A., Conte, U. (1989) System for the controlled-rate release of active substance. US Patent 4,839,177
7. Colombo, P., Catellani, P. L., Peppas, N. A., Maggi, L., Conte, U. (1992) Swelling characteristics of hydrophilic matrices for controlled release: New dimensionless number to describe the swelling and release behavior. Int. J. Pharm. 88: 99-109
8. Conte, U., Maggi, L., Colombo, P., La Manna, A. (1993) Multi-layered hydrophilic matrices as constant release devices (Geomatrix systems). J. Control. Release 26: 39-47
9. Conte, U., La Manna, A., Colombo, P. (1995) Tablets with controlled-rate release of active substances. US Patent 5,422,123
10. Fan, L. T., Singh, S. K. (1989) Controlled Release, A Quantitative Treatment. Springer-Verlag, New York
11. Fassihi, R., Yang, L. (1998) Controlled release drug delivery system. US Patent 5,783,212
12. Harland, R. S., Gazzaniga, A., Sangalli, M. E., Colombo, P., Peppas, N. A. (1988) Drug/polymer matrix swelling and dissolution. Pharm. Res. 5: 488-494
13. Hopfenberg, H. B., Hsu, K. C. (1978) Swelling-controlled, constant rate delivery systems. Polym. Eng. Sci. 18: 1186-1191
14. Hsieh, D. S. T., Rhine, W. D., Langer, R. (1983) Zero-order controlled-release polymeric matrices for micro- and macro-molecules. J. Pharm. Sci. 72: 17-22
15. Kim, H., Fassihi, R. (1997a) Application of a binary polymer system in drug release rate modulation. 1. Characterization of release mechanism. J. Pharm. Sci. 86: 316-322
16. Kim, H., Fassihi, R. (1997b) A new ternary polymeric matrix system for controlled drug delivery of highly soluble drugs: I. Diltiazem hydrochloride. Pharm. Res. 14: 1415-1421
17. Narasimhan, B., Peppas, N. A. (1997) Molecular analysis of drug delivery systems controlled by dissolution of the polymer carrier. J. Pharm. Sci. 86: 297-304
18. Paul, D. R., McSpadden, S. K. (1976) Diffusional release of a solute from a polymeric matrix. J. Membr. Sci. 1: 33-48
19. Pham, A. T., Lee, P. I. (1994) Probing the mechanisms of drug release from hydroxypropylmethyl cellulose matrices. Pharm. Res. 11: 1379-1384
20. Siepmann, J., Streubel, A., Peppas, N. A. (2002) Understanding and predicting drug delivery from hydrophilic matrix tablets using the "sequential layer" model. Pharm. Res. 19: 306-314
21. Tu, Y.-O. (1977) A multi-phase Stefan problem describing the swelling and the dissolution of glassy polymer. Q. Appl. Math. 35: 269-285
22. Yang, L., Fassihi, R. (1996) Zero-order release kinetics from a self-correcting floatable asymmetric configuration drug delivery system. J. Pharm. Sci. 85: 170-173
23. Yang, L., Johnson, B., Fassihi, R. (1998) Determination of continuous changes in the gel layer thickness of poly(ethylene oxide) and HPMC tablets undergoing hydration: A texture analysis study. Pharm. Res. 15: 1902-1906
24. Vrenta, J. S., Jarzebski, C. M., Duda, J. L. (1975) A Deborah number for diffusion in polymer-solvent systems. AIChE J. 21: 894-901
25. Wilding, I. R., Coupe, A. J., Davis, S. S. (2001) The role of gamma-scintigraphy in oral drug delivery. Adv. Drug. Deliv. Rev. 46: 103-124