The Site of Action of Epidural Fentanyl: What Can Be Learned by Studying the Difference Between Infusion and Bolus Administration? The Importance of History, One Hopes

Anesthesia and Analgesia

Volumn 97, Issue 5, 2003, Pages 1211-1213

  Mather, Laurence E ^a   Cousins, Michael J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; FENTANYL; PETHIDINE;

ANALGESIC ACTIVITY; BOLUS INJECTION; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG INFUSION; DRUG MECHANISM; EDITORIAL; HUMAN; PRIORITY JOURNAL; SPINAL ANESTHESIA;

EID: 0142181302     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000092951.32643.A6     Document Type: Editorial

References (12)

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2. Glynn CJ, Mather LE, Cousins MJ, et al. Peridural meperidine in humans: analgetic response, pharmacokinetics and transmission into CSF. Anesthesiology 1981;55:520-6.
3. Cousins MJ, Mather LE. Intrathecal and epidural administration of opioids. Anesthesiology 1984;61:276-309.
4. Gourlay GK, Murphy TM, Plummer JL, et al. Pharmacokinetics of fentanyl in lumbar and cervical CSF following lumbar epidural and intravenous injection. Pain 1989;38:253-9.
5. Ginosar Y, Riley ET, Angst MS. The site of action of epidural fentanyl in humans: the difference between infusion and bolus administration. Anesth Analg 2003;97:1428-38.
6. Ginosar Y, Columb MO, Cohen SE, et al. The site of action of epidural fentanyl infusions in the presence of local anesthetics: a minimum local analgesic concentration infusion study in nulliparous labor. Anesth Analg 2003;97:1439-45.
7. Tucker GT, Mather LE. Properties, absorption and disposition of local anesthetics. In: Cousins MJ, Bridenbaugh PO, eds. Neural blockade. 3rd ed. Lippincott: Philadelphia, 1998:55-95.
8. Yeung JC, Rudy TA. Sites of antinociceptive action of systemically injected morphine: involvement of supraspinal loci as revealed by intracerebroventricular injection of naloxone. J Pharmacol Exp Ther 1980;215:626-32.
9. Yeung JC, Rudy TA. Multiplicative interaction between narcotic agonisms expressed at spinal and supraspinal sites of antinociceptive action as revealed by concurrent intrathecal and intracerebroventricular injections of morphine. J Pharmacol Exp Ther 1980;215:633-42.
10. Gourlay GK, Kowalski SR, Plummer JL, et al. Fentanyl blood concentration-analgesic response relationship in the treatment of postoperative pain Anesth Analg 1988;67:329-37.
11. Woodhouse A, Mather LE. The minimum effective concentration (MEC) of opioids: a revisitation with PCA fentanyl. Reg Anesth Pain Med 2000;25:259-67.
12. Mather LE, Woodhouse A, Ward ME, et al. Pulmonary administration of aerosolised fentanyl: pharmacokinetic evaluation of systemic delivery. Brit J Clin Pharmacol 1998;46:37-43.