pH-Stress and Toxicity of Nitrophenols to Tetrahymena pyriformis

Bulletin of Environmental Contamination and Toxicology

Volumn 71, Issue 5, 2003, Pages 1069-1076

  Schultz, T W ^a   Burgan, J T ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 4 NITROPHENOL; 2,4 DINITROPHENOL; 2,5 DINITROPHENOL; 2,6 DINITRO 4 METHYLPHENOL; 2,6 DINITROPHENOL; 3 NITROPHENOL; 3,5 DINITROPHENOL; 4 CHLORO 2 NITROPHENOL; 4 CHLORO 3 NITROPHENOL; DINITRO ORTHO CRESOL; NITROPHENOL; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ECOTOXICITY; GROWTH INHIBITION; NONHUMAN; PH; PHYSICAL CHEMISTRY; TETRAHYMENA PYRIFORMIS; TOXICITY TESTING;

ANIMALS; HYDROGEN-ION CONCENTRATION; LETHAL DOSE 50; NITROPHENOLS; TETRAHYMENA; WATER POLLUTANTS, CHEMICAL;

TETRAHYMENA; TETRAHYMENA PYRIFORMIS;

EID: 0142178020     PISSN: 00074861     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00128-003-9013-8     Document Type: Article

References (23)

1. Aptula AO, Netzeva TI, Valkova IV, Cronin MTD, Schultz TW, Kühne R, Schüürmann G (2002) Multivariate discrimination between modes of toxic action of phenols. Quant Struct-Act Relat 21:12-22
2. Barron MG (1990) Bioconcentration; will water-borne organic chemicals accumulate in aquatic animals? Environ Sci Technol 24:1612-1618
3. Cameron IL (1973) Growth characteristics of Tetrahymena. In: Elliott AM (ed) Biology of Tetrahymena. Dowden, Hutchinson & Ross, Pennsylvania, p 199-225
4. Conner RL, Goldberg R, Kirnacker MS (1961) The influence of hydrogen ion concentration and 2,4-dinitrophenol on orthophosphate accumulation in Tetrahymenapyriformis. J Gen Microbiol 24:239-246
5. Cronin MTD, Schultz TW (1996) Structure-toxicity relationships for phenols to Tetrahymena pyriformis. Chemosphere 32:1453-1468
6. Cronin MTD, Aptula AO, Duffy JC, Netzeva TI, Rowe PH, Valkova IV, Schultz TW (2002) Comparative assessment of methods to develop QSARs for the prediction of the toxicity of phenols to Tetrahymena pyriformis. Chemosphere 49:1201-1221
7. Cronin MTD, Zhao YH, Yu RL (2000) pH-dependence and QSAR analysis of the toxicity of phenols and anilines to Daphnia magna. Environ Toxicol 15:140-148
8. th ed. McGraw-Hill Publishing, New York, p 8.19-8.79
9. Escher BI, Schwarzenbach RP (2002) Mechanistic studies on baseline toxicity and uncoupling of organic chemicals as a basis for modeling effective membrane concentrations in aquatic organisms. Aquat Sci 64:20-35
10. Hamburger K, Zeuthen E (1957) Synchronous divisions in Tetrahymena pyriformis as studied in an inorganic medium. The effect of 2,4-dinitrophenol. Exp Cell Res 13:443-453
11. Hanstein WG (1976) Uncoupling of oxidative phosphorylation. Trends Biochem Sci 1:65-67
12. rd International Workshop on Quantitative Structure-Activity Relationships (QSAR) in Environmental Toxicology. NTIS, Springfield, Virginia, p 33-42
13. Könemann H, Musch A (1981) Quantitative structure-activity relationships in fish toxicity studies part 2: The influence of pH on the QSAR of chlorophenols. Toxicology 19:223-228
14. Levy MR (1973) Effects of some environmental factors on the biochemistry, physiology, and metabolism of Tetrahymena. In: Elliott AM (ed) Biology of Tetrahymena. Dowden, Hutchinson & Ross, Pennsylvania, p 227-257
15. March J (1992) Advanced Organic Chemistry: Reactions, Mechanisms and Structure, 4th ed. John Wiley & Sons, New York, p 1495
16. McLaughlin SGA, Dilger J (1980) Transport of protons across membranes by weak acids. Physiol Rev 60:825-863
17. Nilsson JR (1995) pH-dependent effects of 2,4-dinitrophenol (DNP) on proliferation, endocytosis, fine structure and DNP resistance in Tetrahymena. J Euk Microbiol 42:248-255
18. Saarikoski J, Viluksela M (1981) Influence of pH on the toxicity of substituted phenols to fish. Arch Environ Contam Toxicol 10:749-753
19. th ed, vol 2. Cary, North Carolina, p 846
20. Schultz TW (1997) TETRATOX: Tetrahymenapyriformis population growth impairment endpoint-A surrogate for fish lethality. Toxicol Methods 7:289-309
21. Schultz TW, Bearden AP, Jaworska JS (1996) A novel approach for estimating toxicity of phenols. SAR QSAR Environ Res 5:99-112
22. Schultz TW, Sinks GD, Cronin MTD (1997) Structure-toxicity evaluation of phenols: A mechanism of action approach. In: Fredenslund FC, Schüürmann G (eds) Quantitative Structure-Activity Relationships in Environmental Sciences-VII. SETAC Press, Pensacola, Florida, pp 329-342
23. Terada H (1981) The interaction of highly acute uncouplers with mitochondria. Biochim Biophys Acta 639:225-242