Nitric oxide synthase inhibition does not affect regulation of muscle sympathetic nerve activity during head-up tilt

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 285, Issue 5 54-5, 2003, Pages

  Cui, Jian ^a   Zhang, Rong ^a,b   Wilson, Thad E ^a   Witkowski, Sarah ^a   Crandall, Craig G ^a,b   Levine, Benjamin D ^a,b  

^a PRESBYTERIAN HOSPITAL OF DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Autonomic; Baroreceptors; Microneurography; Nervous system; Orthostatic

Indexed keywords

N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE;

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE MONITORING; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; HEAD POSITION; HEAD TILTING; HEART OUTPUT; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE INNERVATION; NEUROGRAPHY; NORMAL HUMAN; PRESSORECEPTOR; PRIORITY JOURNAL; SYMPATHETIC NERVE; SYMPATHETIC TONE; VASCULAR RESISTANCE;

EID: 0142169978     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.01076.2002     Document Type: Article

References (36)

1. G-methyl-arginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo? Biochem Biophys Res Commun 160: 881-886, 1989.
2. Blackman DJ, Morris-Thurgood JA, Atherton JJ, Ellis GR, Anderson RA, Cockcroft JR, and Frenneaux MP. Endothelium-derived nitric oxide contributes to the regulation of venous tone in humans. Circulation 101: 165-170, 2000.
3. Castellano M, Rizzoni D, Beschi M, Muiesan ML, Porteri E, Bettoni G, Salvetti M, Cinelli A, Zulli R, and Agabiti-Rosei E. Relationship between sympathetic nervous system activity, baroreflex and cardiovascular effects after acute nitric oxide synthesis inhibition in humans. J Hypertens 13: 1153-1161, 1995.
4. Chavoshan B, Sander M, Sybert TE, Hansen J, Victor RG, and Thomas GD. Nitric oxide-dependent modulation of sympathetic neural control of oxygenation in exercising human skeletal muscle. J Physiol 540: 377-386, 2002.
5. Cooke WH, Zhang R, Zuckerman JH, Cui J, Wilson TE, Crandall CG, and Levine BD. Does nitric oxide buffer arterial blood pressure variability in humans? J Appl Physiol 93: 1466-1470, 2002.
6. Crandall CG, Shibasaki M, and Yen TC. Evidence that the human cutaneous venoarteriolar response is not mediated by adrenergic mechanisms. J Physiol 538: 599-605, 2002.
7. Cui J, Wilson TE, and Crandall CG. Baroreflex modulation of muscle sympathetic nerve activity during cold pressor test in humans. Am J Physiol Heart Circ Physiol 282: H1717-H1723, 2002.
8. Cui J, Wilson TE, Shibasaki M, Hodges NA, and Crandall CG. Baroreflex modulation of muscle sympathetic nerve activity during posthandgrip muscle ischemia in humans. J Appl Physiol 91: 1679-1686, 2001.
9. Doba N and Reis DJ. Role of the cerebellum and the vestibular apparatus in regulation of orthostatic reflexes in the cat. Circ Res 40: 9-18, 1974.
10. Furchgott RF and Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376, 1980.
11. Hamilton CA, Berg G, McIntyre M, McPhaden AR, Reid JL, and Dominiczak AF. Effects of nitric oxide and superoxide on relaxation in human artery and vein. Atherosclerosis 133: 77-86, 1997.
12. Hansen J, Jacobsen TN, and Victor RG. Is nitric oxide involved in the tonic inhibition of central sympathetic outflow in humans? Hypertension 24: 439-444, 1994.
13. Harada S, Tokunaga S, Momohara M, Masaki H, Tagawa T, Imaizumi T, and Takeshita A. Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits. Circ Res 72: 511-516, 1993.
14. Hogan N, Casadei B, and Paterson DJ. Nitric oxide donors can increase heart rate independent of autonomic activation. J Appl Physiol 87: 97-103, 1999.
15. Imadojemu VA, Lott ME, Gleeson K, Hogeman CS, Ray CA, and Sinoway LI. Contribution of perfusion pressure to vascular resistance response during head-up tilt. Am J Physiol Heart Circ Physiol 281: H371-H375, 2001.
16. Jacobsen TN, Morgan BJ, Scherrer U, Vissing SF, Lange RA, Johnson N, Ring WS, Rahko PS, Hanson P, and Victor RG. Relative contributions of cardiopulmonary and sinoaortic baroreflexes in causing sympathetic activation in the human skeletal muscle circulation during orthostatic stress. Circ Res 73: 367-378, 1993.
17. Jimbo M, Suzuki H, Ichikawa M, Kumagai K, Nishizawa M, and Saruta T. Role of nitric oxide in regulation of baroreceptor reflex. J Auton Nerv Syst 50: 209-219, 1994.
18. G-monomethyl-L-arginine into humans are dose dependent. J Hypertens 16: 519-523, 1998.
19. Levine BD, Zuckerman JH, and Pawelczyk JA. Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance. Circulation 96: 517-525, 1997.
20. Mayer BX, Mensik C, Krishnaswami S, Derendorf H, Eichler HG, Schmetterer L, and Wolzt M. Pharmacokinetic-pharmacodynamic profile of systemic nitric oxide synthase inhibition with L-NMMA in humans. Br J Clin Pharmacol 47: 539-544, 1999.
21. Miyano H, Kawada T, Shishido T, Sato T, Sugimachi M, Alexander J Jr, and Sunagawa K. Inhibition of NO synthesis minimally affects the dynamic baroreflex regulation of sympathetic nerve activity. Am J Physiol Heart Circ Physiol 272: H2446-H2452, 1997.
22. Miyano H, Kawada T, Sugimachi M, Shishido T, Sato T, Alexander J Jr, and Sunagawa K. Inhibition of NO synthesis does not potentiate dynamic cardiovascular response to sympathetic nerve activity. Am J Physiol Heart Circ Physiol 273: H38-H43, 1997.
23. Owlya R, Vollenweider L, Trueb L, Sartori C, Lepori M, Nicod P, and Scherrer U. Cardiovascular and sympathetic effects of nitric oxide inhibition at rest and during static exercise in humans. Circulation 96: 3897-3903, 1997.
24. Palmer RM, Ferrige AG, and Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524-526, 1987.
25. Palmer RM, Rees DD, Ashton DS, and Moncada S. L-Arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun 153: 1251-1256, 1988.
26. Pontieri V, Venezuela MK, Scavone C, and Michelini LC. Role of endogenous nitric oxide in the nucleus tratus solitarii on baroreflex control of heart rate in spontaneously hypertensive rats. J Hypertens 16: 1993-1999, 1998.
27. Rees DD, Palmer RM, and Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 86: 3375-3378, 1989.
28. Sander M, Chavoshan B, and Victor RG. A large blood pressure-raising effect of nitric oxide synthase inhibition in humans. Hypertension 33: 937-942, 1999.
29. Shamsuzzaman AS, Sugiyama Y, Kamiya A, Fu Q, and Mano T. Head-up suspension in humans: effects on sympathetic vasomotor activity and cardiovascular responses. J Appl Physiol 84: 1513-1519, 1998.
30. , Spieker LE, Corti R, Binggeli C, Luscher TF, and Noll G. Baroreceptor dysfunction induced by nitric oxide synthase inhibition in humans. J Am Coll Cardiol 36: 213-218, 2000.
31. Stamler JS, Loh E, Roddy MA, Currie KE, and Creager MA. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 89: 2035-2040, 1994.
32. Tseng CJ, Liu HY, Lin HC, Ger LP, Tung CS, and Yen MH. Cardiovascular effects of nitric oxide in the brain stem nuclei of rats. Hypertension 27: 36-42, 1996.
33. Vallance P, Collier J, and Moncada S. Nitric oxide synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivo. Cardiovasc Res 23: 1053-1057, 1989.
34. Vallbo AB, Hagbarth KE, Torebjork HE, and Wallin BG. Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. Physiol Rev 59: 919-957, 1979.
35. Zanzinger J, Czachurski J, and Seller H. Inhibition of basal and reflex-mediated sympathetic activity in the RVLM by nitric oxide. Am J Physiol Regul Integr Comp Physiol 268: R958-R962, 1995.
36. Zhang R, Zuckerman JH, Pawelczyk JA, and Levine BD. Effects of head-down-tilt bed rest on cerebral hemodynamics during orthostatic stress. J Appl Physiol 83: 2139-2145, 1997.