Fatal outcome in a patient with metastatic prostate cancer and acquired severe hypogammaglobulinemia with complete absence of mature peripheral blood B-cells

In Vivo

Volumn 17, Issue 5, 2003, Pages 505-507

  Lohr, Jens ^a   Mielke, Stephan ^a   Lübbert, Michael ^a   Behringer, Dirk ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

B cell aplasia; Common variable immunodeficiency; CVID; Hypogammaglobulinemia

Indexed keywords

ACETYLSALICYLIC ACID; ALBUMIN; ANTIBIOTIC AGENT; BUDESONIDE; CD19 ANTIGEN; CD3 ANTIGEN; CD34 ANTIGEN; ENALAPRIL; FOSFESTROL; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PREDNISOLONE; THEOPHYLLINE;

AGED; APLASIA; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE APLASIA; BONE MARROW EXAMINATION; CASE REPORT; COMMON VARIABLE IMMUNODEFICIENCY; DISEASE SEVERITY; DRUG TOXICITY; FATALITY; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNOPHENOTYPING; LYMPHOCYTOPENIA; MALE; METASTASIS; PERIPHERAL LYMPHOCYTE; PNEUMONIA; PROSTATE CANCER; SEPSIS; WASTING SYNDROME; WEIGHT REDUCTION;

EID: 0142167938     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Cunningham-Rundles C: Clinical and immunologic analyses of 103 patients with common variable immunodeficiency. J Clin Immunol 9: 22-33, 1989.
2. Bryant A, Calver NC, Toubi E, Webster AD and Farrant J: Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2. Clin Immunol Immunopathol 56: 239-248, 1990.
3. French MA and Dawkins RL: Central MHC genes, IgA deficiency and autoimmune disease [see comments]. Immunol Today 11: 271-274, 1990.
4. Meffre E, LeDeist F, De Saint-Basile G, Deville A, Fougereau M, Fischer A and Schiff C: A non-XLA primary deficiency causes the earliest known defect of B cell differentiation in humans: A comparison with an XLA case. Immunol Lett 57: 93-99, 1997.
5. Denz A, Eibel H, Illges H, Kienzle G, Schlesier M and Peter HH: Impaired up-regulation of CD86 in B cells of "type A" common variable immunodeficiency patients. Eur J Immunol 30: 1069-1077, 2000.
6. Rump JA, Jahreis A, Schlesier M, Drager R, Melchers I and Peter HH: Possible role of IL-2 deficiency for hypogammaglobulinaemia in patients with common variable immunodeficiency. Clin Exp Immunol 89: 204-210, 1992.
7. Farrington M, Grosmaire LS, Nonoyama S, Fischer SH, Hollenbaugh D, Ledbetter JA, Noelle RJ, Aruffo A and Ochs HD: CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency. Proc Natl Acad Sci USA 91: 1099-1103, 1994.
8. Conley ME and Cooper MD: Genetic basis of abnormal B cell development. Curr Opin Immunol 10: 399-406, 1998.
9. Eriksson S: Leukoerythroblastic anemia and hypogammaglobulinemia in prostatic cancer with bone marrow metastasis. Nordisk Med 84: 1573-1574, 1970.
10. Millar BC, Bell JB, Hobbs SM, Jackson E and Hall JG: Lymphotoxic activity of methyl prednisolone in vitro-I. Comparative toxicity of methyl prednisolone in human cell lines of B and T origin. Biochem Pharmacol 36: 831-817, 1987.
11. Crout JE, Hepburn B and Ritts RE Jr: Suppression of lymphocyte transformation after aspirin ingestion. New Engl J Med 292: 221-223, 1975.
12. Mentz F, Merle-Beral H, Ouaaz F and Binet JL: Theophylline, a new inducer of apoptosis in B-CLL: Role of cyclic nucleotides. Br J Haematol 90: 957-959, 1995.
13. Narasimhan P and Amaral L: Lymphopenic response of patients presenting with chronic lymphocytic leukemia associated with carcinoma of the prostate to diethylstilbestrol: Correlation of response to the in vitro synthesis of RNA by patient lymphocytes and its relationship to transcortin. Am J Hematol 8: 369-375, 1980.