Experimental model of obstructive, chronic pancreatitis in pigs

Digestive Surgery

Volumn 20, Issue 6, 2003, Pages 520-526

  Boerma, D ^a   Straatsburg, I H ^a   Offerhaus, G J A ^a   Gouma, D J ^a   Van Gulik, T M ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Animal model; Chronic inflammation; Chronic pancreatitis; Fibrosis; Stellate cells

Indexed keywords

AMYLASE; CHOLECYSTOKININ; COLLAGEN; SECRETIN; TRIACYLGLYCEROL LIPASE;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; CELL COUNT; CELL PROLIFERATION; CHEMICAL ANALYSIS; CHRONIC DISEASE; CHRONIC OBSTRUCTIVE PANCREATITIS; CHRONIC PANCREATITIS; CONTROLLED STUDY; ENZYME ACTIVITY; EXPERIMENTAL MODEL; FEMALE; FUNCTIONAL ASSESSMENT; GLUCOSE TOLERANCE; HISTOPATHOLOGY; LANGERHANS CELL; LIGATION; METAPLASIA; NONHUMAN; PANCREAS ACINUS; PANCREAS DUCT; PANCREAS DUCT LIGATION; PANCREAS ISLET; PANCREAS JUICE; PANCREAS SURGERY; PANCREATITIS; PARAMETER; PATHOLOGY; PATHOPHYSIOLOGY; PLASMA; PRESSURE MEASUREMENT; PROTEIN BLOOD LEVEL; REPRODUCIBILITY; STELLATE CELL; STENOSIS, OCCLUSION AND OBSTRUCTION; STIMULATION; SWINE; TISSUE;

ANIMALS; CHRONIC DISEASE; CONSTRICTION, PATHOLOGIC; FEMALE; LIGATION; MODELS, ANIMAL; PANCREATIC DUCTS; PANCREATITIS; SWINE;

EID: 0142165849     PISSN: 02534886     EISSN: None     Source Type: Journal    
DOI: 10.1159/000073688     Document Type: Article

References (16)

1. Smits ME, Badiga SM, Rauws EA, Tytgat GN, Huibregtse K: Long-term results of pancreatic stents in chronic pancreatitis. Gastrointest Endosc 1995;42:461-467.
2. Greenlee HB, Prinz RA, Aranha GV: Long-term results of side-to-side pancreaticojejunostomy. World J Surg 1990;14:70-76.
3. Capella C, Solcia E: The endocrine cells of the pig gastrointestinal mucosa and pancreas. Arch Histol Jpn 1972;35:1-29.
4. Swindle MM, Smith AC, Hepburn BJ: Swine as models in experimental surgery. J Invest Surg 1988;1:65-79.
5. Rahko T, Kalima TV, Saloniemi H: Pancreatic duct obstruction in the pig: Light microscopy of chronic pancreatitis. Acta Vet Scand 1987;28:285-289.
6. Pitkaranta P, Kivisaari L, Nordling S, Saari A, Schroder T: Experimental chronic pancreatitis in the pig. Scand J Gastroenterol 1989;24:987-992.
7. Singh SM, Reber HA: The pathology of chronic pancreatitis. World J Surg 1990;14:2-10.
8. Valderrama R, Navarro S, Lopez JM, Caballeria J, Gimenez A, Pares A, et al: Synthesis and degradation of collagen in pancreatic fibrogenesis. Pancreas 1999;18:34-38.
9. Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, et al: Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998;115:421-432.
10. Haber PS, Keogh GW, Apte MV, Moran CS, Stewart NL, Crawford DH, et al: Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol 1999;155:1087-1095.
11. De Angelis C, Valente G, Spaccapietra M, Angonese C, De Favero G, Naccarato R, et al: Histological study of alcoholic, nonalcoholic, and obstructive chronic pancreatitis. Pancreas 1992;7:193-196.
12. Austin JL, Roberts C, Rosenholtz MJ, Reber HA: Effects of partial duct obstruction and drainage of pancreatic function. J Surg Res 1980;28:426-433.
13. Karanjia ND, Widdison AL, Leung F, Alvarez C, Lutrin FJ, Reber HA: Compartment syndrome in experimental chronic obstructive pancreatitis: Effect of decompressing the main pancreatic duct. Br J Surg 1994;81:259-264.
14. Patel AG, Reber PU, Toyama MT, Ashley SW, Reber HA: Effect of pancreaticojejunostomy on fibrosis, pancreatic blood flow, and interstitial pH in chronic pancreatitis: A feline model. Ann Surg 1999;230:672-679.
15. Izbicki JR, Bloechle C, Broering DC, Kuechler T, Broelsch CE: Longitudinal V-shaped excision of the ventral pancreas for small duct disease in severe chronic pancreatitis: Prospective evaluation of a new surgical procedure. Ann Surg 1998;227:213-219.
16. Nealon WH, Townsend CM Jr, Thompson JC: Operative drainage of the pancreatic duct delays functional impairment in patients with chronic pancreatitis. A prospective analysis. Ann Surg 1988;208:321-329.