Pharmacokinetic studies of telithromycin in mouse, rat and dog

Japanese Journal of Chemotherapy

Volumn 51, Issue SUPPL. 1, 2003, Pages 182-199

  Yamazaki, Hiroko ^a   Roeder, V ^b   Vicat, P ^b   Bonnat, C ^b   Rainbeaud, M ^b   Mauriac, C ^b   Laplace, H ^b   Jaulin, F ^b   Haegele, K D ^b   Meili, M ^b   Labbe, G ^b   Abecassis, P Y ^b   Flor, M ^b   Fougeat, S ^b   Dupront, A ^b   Coussediere, D ^b   Lenfant, B ^b  

^a Aventis Pharma Ltd   (Japan)

^b SANOFI   (France)

Author keywords

Telithromycin

Indexed keywords

ALKANE DERIVATIVE; AMINE; CYTOCHROME P450 3A; DEXAMETHASONE; DRUG METABOLITE; N DEMETHYLASE; PLASMA PROTEIN; PYRIDINE DERIVATIVE; RU 72365; RU 76363; RU 76584; RU 78849; TELITHROMYCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CENTRAL NERVOUS SYSTEM; DOG; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; FECES; FEMALE; GASTROINTESTINAL TRACT; MALE; MOUSE; NONHUMAN; RADIOACTIVITY; RAT; STRUCTURE ANALYSIS; URINARY EXCRETION;

EID: 0142148285     PISSN: 13407007     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Ullberg S: The technique of whole-body autoradiography, Cryosectioning of larg specimen. Science tools, the LKB Instrument Joumal, Pul.: LKB-Produkter AB-BROMMA-SWEDEN, Ed. Alyfeld O, Special issue: 2-29, 1977
2. Urien S: MicroPharm, a software designed to analyse pharmacological data from kinetic, binding and tissue extraction expriments. Bull. Cancer 78: 654, 1991
3. Beaune P, Flinois J P Kiffel L, et al.: Purification of a new cytochrome P-450 from human liver microsomes. Biochem. Biophys. Acta. 840: 364-370, 1985
4. Lowry O H, Rosebrough N J, Farr A L, et al.: Protein measurement with the folin phenol reagent. J. Biol. Chem 193: 265-275, 1951
5. Omura T, Sato R: The carbon monoxide-binding pigment of liver microsomes. 1. Evidence for its hemoprotein nature. J. Biol. Chem. 239: 2370-2378, 1964
6. Larrey D, Tinel M, Pessayre D: Formation of inactive cytochrome P-450 Fe (II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in rats. Biochemical Pharmacology 32: 1487-1493, 1983
7. Danan G, Descatoire V, Pessayre D: Self induction by erythromycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450. J. Pharmac. Exp. Ther. 218: 509-514, 1981
8. Varoquaux O, Advenier C, Renier E: Troleandomycin acetate, dangerous drug combination. Gaz. Med. France 88: 1625-1629, 1981
9. Branigan T A, Robblins R A, Cady W Y, et al.: The effects of erythromycin on the absorption and disposition kinetics of theophyline. Eur. J. Pharmacol. 21: 115-120, 1981
10. Amacher D E, Schomaker S J, Retsema J A: Comparison of the effects of the new azide antibiotic, Azithromycin, and Erythromycin estolate on rat liver cytochrome P-450. Antimicrob. Agents Chemother. 35: 1186-1190, 1991