Cardiac enkephalins attenuate vagal bradycardia: Interactions with NOS-1-cGMP systems in canine sinoatrial node

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 285, Issue 5 54-5, 2003, Pages

  Farias III, Martin ^a   Jackson, Keith ^a   Johnson, Michael ^a   Caffrey, James L ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

cAMP; Cardiac pacemaker; Heart rate; Nitric oxide; Opioids; Phosphodiesterase

Indexed keywords

7 NITROINDAZOLE; 8 BROMO CYCLIC GMP; ARGININE; CYCLIC AMP; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; DEXTRO ARGININE; ENKEPHALIN; ISOBUTYLMETHYLXANTHINE; METENKEPHALIN[6 ARGININE 7 PHENYLALANINE]; METHACHOLINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OPIATE; PHOSPHODIESTERASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; BRADYCARDIA; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DOG; DRUG EFFECT; DRUG SPECIFICITY; ENZYME ACTIVITY; HEART; HEART FUNCTION; HEART RATE; MICRODIALYSIS; NERVE ENDING; NONHUMAN; PARASYMPATHETIC NERVE; PRIORITY JOURNAL; PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SINUS NODE; VAGUS NERVE; VAGUS NERVE STIMULATION;

EID: 0142139306     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00275.2003     Document Type: Article

References (30)

1. Alderton WK, Cooper CE, and Knowles RG. Nitric oxide synthases, structure, function and inhibition. Biochem J 357: 593-615, 2001.
2. Bhargava HN and Cao YJ. Effect of chronic administration of [D-Pen2, D-Pen5] enkephalin on the activity of nitric oxide synthase in brain regions and spinal cord of mice. Peptides 19: 113-117, 1998.
3. Bhargava HN and Cao YJ. Effect of chronic administration of morphine, U-50,488H and [D-Pen2, D-Pen5] enkephalin on the concentration of cGMP in brain regions and spinal cord of mice. Peptides 18: 1629-1634, 1997.
4. Caffrey JL. Enkephalin inhibits vagal control of heart rate, contractile force, and coronary blood flow in canine heart in vivo. J Auton Nerv Syst 76: 75-82, 1999.
5. Caffrey JL, Mateo Z, Napier LD, Gaugl JF, and Barron BA. Intrinsic cardiac enkephalins inhibit vagal bradycardia in the dog. Am J Physiol Heart Circ Physiol 268: H848-H855, 1995.
6. Caffrey JL, Wooldridge CB, and Gaugl JF. The interaction of endogenous opiates with autonomic circulatory control in the dog. Circ Shock 17: 233-242, 1985.
7. Choate JK, Danson EJF, Morris JF, and Paterson DJ. Peripheral vagal control of heart rate is impaired in neuronal NOS knockout mice. Am J Physiol Heart Circ Physiol 281: H2310-H2317, 2001.
8. Chowdhary S, Vaile JC, Fletcher J, Ross HF, Coote JH, and Townend JN. Nitric oxide and cardiac autonomic control in humans. Hypertension 36:264-269, 2000.
9. Chowdhary S and Townend JN. Role of nitric oxide in the regulation of cardiovascular autonomic control. Clin Sci (Lond) 97: 5-17, 1999.
10. Conlon K, Collins T, and Kidd C. The role of nitric oxide in the control by the vagal nerves of the heart of the ferret. Exp Physiol 83:469-480, 1998.
11. Conlon K and Kidd C. Neuronal nitric oxide facilitates vagal chronotropic and dromotropic actions on the heart. J Auton Nerv Syst 75: 136-146, 1999.
12. Deliconstantinos G, Villiotou V, and Stavrides JC. Metenkephalin receptor mediated increase of membrane fluidity modulates nitric oxide and cGMP production in rat brain synaptosomes. Neurochem Res 20: 217-224, 1995.
13. Elvan A, Rubart M, and Zipes DP. NO modulates autonomic effects on sinus discharge rate and AV nodal conduction in open chest dogs. Am J Physiol Heart Circ Physiol 272: H263-H271, 1997.
14. Farias M, Jackson K, Stanfill A, and Caffrey JL. Local opiate receptors in the sinoatrial node moderate vagal bradycardia. Auto Neuro 87: 9-15, 2001.
15. Farias M, Jackson K, Yoshishige D, and Caffrey JL. Cardiac enkephalins interrupt vagal bradycardia via δ-2 opioid receptors in the sinoatrial node. Am J Physiol Heart Circ Physiol 284: H1693-H1710, 2003.
16. Hare JM and Colucci WS. Role of nitric oxide in the regulation of myocardial function. Prog Cardiovasc Dis 38: 155-166, 1995.
17. Herring N, Danson EJF, and Paterson DJ. Cholinergic control of heart rate by nitric oxide is site specific. News Physiol Sci 17: 202-206, 2002.
18. Herring N, Golding S, and Paterson DJ. Pre-synaptic NO-cGMP pathway modulates vagal control of heart rate in isolated adult guinea pig atria. J Mol Cell Cardiol 32: 1795-1804, 2000.
19. Israel M and Manaranche R. The release of acetylcholine: from a cellular towards a molecular mechanism. Biol Cell 55: 1-14, 1985.
20. Jackson K, Farias M, Stanfill A, and Caffrey JL. Delta opioid receptors inhibit vagal bradycardia in the sinoatrial node. J Cardiovasc Pharmacol Therapeut 6: 385-393, 2001.
21. Jackson K, Farias M, Stanfill A, and Caffrey JL. Transient arterial occlusions raise enkephalin in the sinoatrial node and improve vagal bradycardia in canines. Auton Neuro 94: 84-92, 2001.
22. Klimaschewski L, Kummer W, Mayer B, Courand JY, Preissler U, Philippin B, and Heym C. Nitric oxide synthase in cardiac nerve fibers and neurones of rat and guinea pig heart. Circ Res 71: 1533-1537, 1992.
23. Lenard L, Halmai V, and Bartho L. Morphine contracts the guinea pig ileal circular muscle by interfering with a nitric oxide mediated tonic inhibition. Digestion 60: 562-526, 1999.
24. Salto C, Calvet R, Guitart X, Solsona C, and Marsal J. Opiates depress ACh and ATP release from cholinergic synaptosomes by blocking calcium uptake. Toxicol Appl Pharmacol 106: 26-27, 1990.
25. Schwarz P, Diem R, Dun NJ, and Fosterman U. Endogenous and exogenous nitric oxide inhibits norepinephrine release from rat heart sympathetic nerves. Circ Res 77: 841-848, 1995.
26. Searles CD. The nitric oxide pathway and oxidative stress in heart failure. Congest Heart Fail 8: 142-147, 2002.
27. Sears CE, Choate JK, and Paterson DJ. NO-cGMP pathway accentuates the decrease in heart rate caused by cardiac vagal nerve stimulation. J Appl Physiol 86: 510-516, 1999.
28. Stefano GB, Salzet M, Hughes TK, and Bilfinger TV. Delta II opioid receptor subtype on human vascular endothelium uncouples morphine stimulated nitric oxide release. Int J Cardiol 30, Suppl 1: S43-S51, 1998.
29. Tanaka K, Okshima H, Hiroyasu E, and Tnemichi E. Direct synaptic contacts of nitric oxide synthase-immunoreactive nerve terminals on the neurones of the intracardiac ganglia of the guinea pig. Neurosci Lett 158: 67-70, 1993.
30. Younes A, Pepe S, Barron BA, Spurgeon H, Lakatta EG, and Caffrey JL. High rates of proenkephalin processing in rat heart. Am J Physiol Heart Circ Physiol 279: H1989-H1998, 2000.