Synthesis of Long Chain 2-Alkyl-1-(2-hydroxyethyl)-2-imidazolines under Microwave in Solvent-Free Conditions

Synlett

Volumn , Issue 12, 2003, Pages 1847-1849

  Martínez Palou, Rafael ^a   De Paz, Gerardo ^a   Marín Cruz, Jesús ^a   Zepeda, Luis Gerardo ^b  

^a Eje Ctrl Lazaro Cardenas No 152   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Amides; Cyclizations; Imidazolines; Microwave; Solid phase synthesis

Indexed keywords

AMIDE; CALCIUM OXIDE; ETHANOLAMINE DERIVATIVE; IMIDAZOLINE DERIVATIVE; SOLVENT;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; GAS CHROMATOGRAPHY; HEATING; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MICROWAVE IRRADIATION; MICROWAVE OVEN; POLYMERIZATION; PRECURSOR; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0142123932     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-41410     Document Type: Article

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34. 6a
35. Typical Experimental Procedure: In an open Pyrex vessel (100 mL, for DMW) or sealed tube (100 mL, for MMW) were carefully mixed 0.52 g (5.0 mmol) of aminoethylethanolamine (3), 5.0 mmol of the corresponding fatty acid (4a-d) and 2.5 g of CaO. The resulting mixture was irradiated using the power and the reaction time showed in Table 1. The reaction mixture was allowed to reach room temperature, EtOAc (20 mL) was added and the mixture was heated until boiling and filtered off while hot, and the filtrated was concentrated under vacuum to dryness, yielding the corresponding product as a white solid.
36. The thermal heating reaction protocol was as in the case of microwave methodology except that the glass tube containing the reagents and a magnetic stirring bar, was placed into a preheated oil bath at 150°C. The temperature of each was measured for 5 s using a thermometer embedded in the reaction mixture. The work-up procedure was as with the microwave methodology.