Spermicidal efficacy of H2-receptor antagonists and potentiation with 2′, 4′-dichlorobenzamil hydrochloride: Role of intrasperm Ca2+

Contraception

Volumn 68, Issue 1, 2003, Pages 61-64

  Gupta, A ^a   Gupta, S ^a   Tiwary, A K ^a  

^a PUNJABI UNIVERSITY   (India)

Author keywords

2 , 4 Dichlorobenzamil hydrochloride; H2 receptor antagonists; Human sperm; Intrasperm Ca2+; Spermicidal agents

Indexed keywords

2',4' DICHLOROBENZAMIL; BLOCKING AGENT; CALCIUM; CIMETIDINE; FAMOTIDINE; HISTAMINE H2 RECEPTOR ANTAGONIST; RANITIDINE; SPERMICIDAL AGENT; UNCLASSIFIED DRUG; 2',4' DICHLOROBENZAMIL AMILORIDE; 2',4'-DICHLOROBENZAMIL AMILORIDE; AMILORIDE; CELL RECEPTOR; DRUG DERIVATIVE; SODIUM CALCIUM EXCHANGE PROTEIN;

ADULT; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; SODIUM CALCIUM EXCHANGE; SPERM; DRUG EFFECT; IN VITRO STUDY; METABOLISM; SPERMATOZOON; SPERMATOZOON MOTILITY; TIME;

ADULT; AMILORIDE; CALCIUM; CIMETIDINE; FAMOTIDINE; HISTAMINE H2 ANTAGONISTS; HUMANS; MALE; RANITIDINE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SODIUM-CALCIUM EXCHANGER; SPERM MOTILITY; SPERMATOCIDAL AGENTS; SPERMATOZOA; TIME FACTORS;

EID: 0142122798     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0010-7824(03)00102-1     Document Type: Article

References (11)

1. White R.D., Jane S.C., Ratnasooriya W.D., Aitken J. Complementary effects of propranolol and nonoxynol-9 upon human sperm motility. Contraception. 52:1995;241-247.
2. Patni A.K., Gupta S., Sharma A., Tiwary A.K., Garg S.K. Role of intracellular calcium in the spermicidal action of 2′, 4′-dichlorobenzamil, a novel contact spermicide. J Pharm Pharmacol. 53:2001;1387-1392.
3. 2+ exchange inhibitor, on human spermatozoa. Eur J Pharmacol. 418:2001;153-155.
4. Breitbart H., Darshan R., Rubinstein S. Evidence for the presence of ATP-dependent calcium pump and ATPase activity in bull sperm head membranes. Biochem Biophys Res Commun. 122:1984;479-484.
5. 2+-ATPase in maintaining motility in ram spermatozoa. J Biol Chem. 260:1985;11548-11553.
6. 2-receptor antagonists cimetidine and ranitidine on reproductive functions in male mice. Indian J Exp Biol. 29:1991;900-906.
7. WHO Laboratory Manual for Examination of Human Semen and Sperm-cervical Mucus Interaction. Cambridge: Cambridge University Press, 1999.
8. Reynolds TR, Narang BS. In: Cheeseborough M, editor. Medical Laboratory manual for tropical countries. Vol 2. Kent: Butterworth and Co. Ltd., 1984. p.186-7.
9. Biggers J.D., Whitten W.K., Whittingham D.G. The culture of mouse embryos in vitro. Daniel J.C. Methods in mammalian embryology. 1971;86-117 Freeman, San Francisco.
10. Reddy K.V., Sahani K.S., Meherji K.P. Spermicidal activity of magainins in vitro and in vivo studies . Contraception. 53:1996;205-210.
11. Tsien R.Y., Pozzan T., Rink T.J. Calcium homeostasis in intact lymphocytes cytoplasmic free calcium monitored with a new intracellularly trapped fluorescent indicator . J Cell Biol. 94:1982;325-334.