Methodology for studying the effects of topically applied ear drops on otoacoustic emissions in guinea pigs

Journal of Laryngology and Otology

Volumn 117, Issue 9, 2003, Pages 696-699

  Migirov, Lela ^a,b,c   Himmelfarb, Mordechay ^a  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^c Dept Otolaryngol Hd Neck Surg ^*  (Israel)

Author keywords

Drug Toxicity; Otoacoustic Emissions; Pharmaceutical Preparations; Spontaneous

Indexed keywords

CIPROFLOXACIN; EAR DROPS; GENTAMICIN; SODIUM CHLORIDE;

ARTICLE; BLISTER; BONE DEVELOPMENT; CELL FUNCTION; CONTROLLED STUDY; HAIR CELL; INFLAMMATION; INNER EAR; METHODOLOGY; MIDDLE EAR; MIDDLE EAR MUCOSA; NONHUMAN; OTOACOUSTIC EMISSION; SWINE;

ADMINISTRATION, TOPICAL; ANIMALS; CIPROFLOXACIN; DRUG THERAPY, COMBINATION; GENTAMICINS; GUINEA PIGS; HAIR CELLS; MALE; MODELS, ANIMAL; OTOACOUSTIC EMISSIONS, SPONTANEOUS; SODIUM CHLORIDE;

EID: 0142120617     PISSN: 00222151     EISSN: None     Source Type: Journal    
DOI: 10.1258/002221503322334503     Document Type: Article

References (9)

1. Morizono T, Johnstone BM. Ototoxicity of topically applied gentamicin using a statistical analysis of electrophysiological measurement. Acta Otolaryngol 1975;80:389-3
2. Parker FL, James GW. The effect of various topical antibiotic and antibacterial agents on the middle and inner ear of the guinea pig. J Pharm Pharmac 1978;30:236-8
3. Esposito S, Noviello S, D'Errico G, Montanaro C. Topical and oral treatment of chronic otitis media with ciprofloxacin. Arch Otolaryngol Head Neck Surg 1990;116:557-9
4. Brownlee RE, Hulka GF, Prasma J, Pillsbury III HC. Ciprofloxacin. Use as a topical otic preparation. Arch Otolaryngol Head Neck Surg 1992;118:392-6
5. Russel PT, Church CA, Jinn TH, Kim DJ, John EO, Jung TJK. Effects of common topical otic preparations on the morphology of isolated cochlear outer hair cells. Acta Otolaryngol 2001;121:135-9
6. Smelt GJC, Monkhouse WS. The effect of bath water, sea water and swimming pool water on the guinea pig middle ear. J Laryngol Otol 1985;99:1209-16
7. Shi Y, Martin WH. ABR and DPOAE detection of cochlear damage by gentamicin. J Basic Clin Physiol Pharmac 1997;18:141-55
8. Ciesla CJ, Lee KJ. Audiology. In: Lee KJ, ed. Essential Otolaryngology Head and Neck Surgery. Norwalk, Connecticut, VI: Appleton and Lange, 1995;31
9. Ueda H, Nakata S, Hoshino M. Effects of effusion in the middle ear and perforation of the tympanic membrane on otoacoustic emissions in guinea pigs. Hear Res 1998;122:41-6