The Protective Effects of Acetylsalicylic Acid on Free Radical Production in Cisplatin Induced Nephrotoxicity: An Experimental Rat Model

Drug and Chemical Toxicology

Volumn 26, Issue 4, 2003, Pages 259-270

  Ulubaş, Bahar ^a   Çimen, M Y Burak ^a   Apa, Duygu Düşmez ^a   Saritaş, Emel ^a   Muşlu, Necati ^a   Çimen, Özlem Bölgen ^a  

^a MERSIN UNIVERSITY   (Turkey)

Author keywords

Acetylsalicylic acid; Antioxidant status; Cisplatin; Nephrotoxicity

Indexed keywords

ACETYLSALICYLIC ACID; CATALASE; CISPLATIN; CREATININE; FREE RADICAL; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; NITRIC OXIDE SYNTHASE; SUPEROXIDE DISMUTASE; UREA;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CHI SQUARE TEST; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; KIDNEY NECROSIS; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; UREA BLOOD LEVEL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; ASPIRIN; CISPLATIN; DISEASE MODELS, ANIMAL; FREE RADICAL SCAVENGERS; FREE RADICALS; INJECTIONS, INTRAPERITONEAL; KIDNEY; MALE; RATS; RATS, WISTAR;

ANIMALIA; FELIS CATUS;

EID: 0142106817     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.1081/DCT-120024841     Document Type: Article

References (31)

1. Rozencweig, M.; Von Hoff, D.D.; Slavik, M.; Muggia, F.M. Cis-diammine dichloroplatinum(II). A new anticancer drug. Ann. Int. Med. 1977, 86, 803-812.
2. Matsushima, H.; Yonemura, K.; Ohishi, K.; Hishida, A. The role of oxygen free radicals in cisplatin-induced acute renal failure in rats. J. Lab. Clin. Med. 1998, 131, 518-526.
3. Blachley, J.D.; Hill, J.B. Renal and electrolyte disturbances associated with cisplatin. Ann. Int. Med. 1981, 95, 628-632.
4. Cavallo, T. Tubulointerstitial nephritis. In Heptinstall's Pathology of the Kidney; Jennette, J.C., Olson, J.L., Schwartz, M.M., Silva, F.G., Eds.; Lippincott-Raven: Philadelphia, 1998; 667-725.
5. Nadasdy, T.; Racusen, C. Renal injury caused by therapeutic and diagnostic agents and abuse of analgesics and narcotics. In Heptinstall's Pathology of the Kidney; Jennette, J.C., Olson, J.L., Schwartz, M.M., Silva, F.G., Eds.; Lippincott-Raven: Philadelphia, 1998; 811-861.
6. Masuda, H.; Tanaka, T.; Takahama, U. Cisplatin generates superoxide anion by interaction with DNA in a cell-free system. Biochem. Biophys. Res. Commun. 1994, 203, 1175-1180.
7. Kruidering, M.; van de Water, B.; de Heer, E.; Mulder, G.J.; Nagelkerke, J.F. Cisplatin-induced nephrotoxicity in porcine proximal tubular cells, mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain. J. Pharmacol. Exp. Ther. 1997, 280, 638-649.
8. Hannemann, J.; Baumann, K. Cisplatin-induced lipid peroxidation and decrease of gluconeogenesis in rat kidney cortex, different effects of antioxidants and radical scavengers. Toxicology 1988, 51, 119-132.
9. Sadzuka, Y.; Shoji, T.; Takino, Y. Effect of cisplatin on the activities of enzymes which protect against lipid peroxidation. Biochem. Pharmacol. 1992, 43, 1873-1875.
10. Baliga, R.; Zhang, Z.; Baliga, M.; Ueda, N.; Shah, S.V. In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicity. Kidney Int. 1998, 53, 394-401.
11. Zhang, J.G.; Lindup, W.E. Role of mitochondria in cisplatin-induced oxidative damage exhibited by rat renal cortical slides. Biochem. Pharmacol. 1993, 45, 2215-2222.
12. Appenroth, D.; Fröb, S.; Kersten, L.; Splinter, E.K.; Winnefeld, K. Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats. Arch. Toxicol. 1997, 71, 677-683.
13. Baldew, G.; van den Hamer, C.J.A.; Los, G.; Vermeulen, N.P.E.; Goeij, J.J.M.; McVie, J.G. Selenium-induced protection against cis-diammine-dichloroplatinum(II) nephrotoxicity in mice and rats. Cancer Res. 1989, 49, 3020-3023.
14. Bogin, E.; Marom, M.; Levi, Y. Changes in serum; liver and kidneys of cisplatin-treated rats effects of antioxidants. Eur. J. Clin. Chem. Clin. Biochem. 1994, 32, 843-851.
15. Durak, I.; Ozbek, H.; Karaayvaz, M.; Ozturk, H.S. Cisplatin induces acute renal failure by impairing antioxidant system in guinea pigs: effects of antioxidant supplementation on the cisplatin nephrotoxicity. Drug. Chem. Toxicol. 2002, 25, 1-8.
16. Kirkova, M.; Ivancheva, E. Lipid peroxidation and antioxidant enzyme activity in aspirin-treated rats. Gen. Pharmacol. 1995, 26, 613-617.
17. Hermann, M.; Kapiois, S.; Hofbauer, R.; Exner, M. Salicylate inhibits LDL oxidation initiated by superoxide/nitric oxide radicals. FEBS Lett. 1999, 445, 212-214.
18. Lopez-Farre, A.; Riesco, A.; Digiuni, E.; Mosquera, J.R. Aspirin-stimulated nitric oxide production by neutrophils after acute myocardial ischemia in rabbits. Circulation 1996, 94, 83-87.
19. McGahan, M.C. Copper and aspirin treatment increase the antioxidant activity of plasma. Agents Actions 1990, 31, 59-64.
20. Kavutcu, M.; Canbolat, O.; Öztürk, S.; Olcay, E.; Ulutepe, S.; Ekinci, C.; Gökhun, I.H.; Durak, I. Reduced enzymatic antioxidant defense mechanism in kidney tissues from gentamicin-treated guinea pigs: the effects of vitamins E and C. Nephron 1996, 72, 269-274.
21. Lowry, O.; Rosebrough, N.; Farr, L.; Randall, R. Protein measurement with folin phenol reagent. J. Biol. Chem. 1951, 182, 265-275.
22. Beutler, E. Glucose 6 phosphate dehydrogenase. In Red Cell Metabolism. A Manual Biochemical Procedure; Grune and Stratton: New York, 1975; 66-69.
23. Aebi, H. Catalase. In Methods of Enzymatic Analysis; Bergmeyer, H.U., Ed.; Academic Press: New York-London, 1974; 673-677.
24. Paglia, D.E.; Valentine, W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 1967, 70, 158-169.
25. Durak, I.; Canbolat, O.; Kavutcu, M.; Öztürk, H.S.; Yurtarslani, Z. Activities of total, cytoplasmic and mitochondrial superoxide dismutase enzymes in sera and pleural fluids from patients with lung cancer. J. Clin. Lab. Analysis 1996, 10, 17-20.
26. Ignarro, L.J.; Buga, G.M.; Wood, K.S.; Byrns, R.E.; Chaudhuri, G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA 1987, 84, 9265-9269.
27. Van Ye, T.M.; Roza, A.M.; Pieper, G.M.; Henderson, J., Jr.; Johnson, C.P.; Adams, M.B. Inhibition of intestinal lipid peroxidation does not minimize morphological damage. J. Surg. Res. 1993, 55, 553-558.
28. Özturk, H.S.; Çimen, M.Y.B.; Çimen, Ö.B.; Kaçmaz, M.; Durak, I. Oxidant/ antioxidant status of plasma samples from patients with rheumatoid arthritis. Rheumatol. Int. 1999, 19, 35-37.
29. Kukreja, R.C.; Kontas, A.; Hess, M.L.; Ellis, E.S. PG synthase and lipoxygenase generates superoxide in the presence of NAD or NADPH. Circ. Res. 1986, 59, 612-619.
30. Durak, I.; Cimen, B.; Kaçmaz, B.; Gören, D.; Öztürk, S. Aspirin induces erythrocyte nitric oxide synthase activity in in vivo. Clinica. Chemica. Acta 2001, 314, 265-267.
31. McGahan, M.C. Copper and aspirin treatment increase the antioxidant activity of plasma. Agents Actions 1990, 31, 59-64.