The regulatory link between carbon and nitrogen metabolism in Bacillus subtilis: Regulation of the gltAB operon by the catabolite control protein CcpA

Microbiology

Volumn 149, Issue 10, 2003, Pages 3001-3009

  Wacker, Ingrid ^a   Ludwig, Holger ^a   Reif, Irene ^a   Blencke, Hans Matti ^a   Detsch, Christian ^a   Stülke, Jörg ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMMONIA; CARBON; GLUCOSE; GLUTAMATE AMMONIA LIGASE; GLUTAMATE SYNTHASE; GLYCOLYTIC ENZYME; NITROGEN; PHOSPHOTRANSFERASE; REGULATOR PROTEIN;

AMINO ACID METABOLISM; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GROWTH; CARBON METABOLISM; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENE REPRESSION; GLYCOLYSIS; NITROGEN METABOLISM; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; REGULATORY MECHANISM;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 0142106372     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.26479-0     Document Type: Article

References (35)

1. Belitsky, B. R. (2002). Biosynthesis of amino acids of the glutamate and aspartate families, alanine and polyamines. In Bacillus subtilis and its Closest Relatives: from Genes to Cells, pp. 203-231. Edited by A. L. Sonenshein, J. A. Hoch & R. Losick. Washington, DC: American Society for Microbiology.
2. Belitsky, B. R. & Sonenshein, A. L. (1998). Role and regulation of Bacillus subtilis glutamate dehydrogenase genes. J Bacteriol 180, 6298-6305.
3. Belitsky, B. R. & Sonenshein, A. L. (1999). An enhancer element located downstream of the major glutamate dehydrogenase gene of Bacillus subtilis. Proc Natl Acad Sci U S A 96, 10290-10295.
4. Belitsky, B. R., Wray, L. V., Jr, Fisher, S. H., Bohannon, D. E. & Sonenshein, A. L. (2000). Role of TnrA in nitrogen source-dependent repression of Bacillus subtilis glutamate synthase gene expression. J Bacteriol 182, 5939-5947.
5. Blencke, H.-M., Homuth, G., Ludwig, H., Mäder, U., Hecker, M. & Stülke, J. (2003). Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metab Eng 5, 133-149.
6. Bohannon, D. E. & Sonenshein, A. L. (1989). Positive regulation of glutamate biosynthesis in Bacillus subtilis. J Bacteriol 171, 4718-4727.
7. Deutscher, J., Küster, E., Bergstedt, U., Charrier, V. & Hillen, W. (1995). Protein kinase-dependent HPr/CcpA interaction links glycolytic activity to carbon catabolite repression in Gram-positive bacteria. Mol Microbiol 15, 1049-1053.
8. Deutscher, J., Galinier, A. & Martin-Verstraete, I. (2002). Carbohydrate uptake and metabolism. In Bacillus subtilis and its Closest Relatives: from Genes to Cells, pp. 129-150. Edited by A. L. Sonenshein, J. A. Hoch & R. Losick. Washington, DC: American Society for Microbiology.
9. Faires, N., Tobisch, S., Bachem, S., Martin-Verstraete, I., Hecker, M. & Stülke, J. (1999). The catabolite control protein CcpA controls ammonium assimilation in Bacillus subtilis. J Mol Microbiol Biotechnol 1, 141-148.
10. Fillinger, S., Boschi-Muller, S., Azza, S., Dervyn, E., Branlant, G. & Aymerich, S. (2000). Two glyceraldehyde-3-phosphate dehydrogenases with opposite physiological roles in a nonphotosynthetic bacterium. J Biol Chem 275, 14031-14037.
11. Fisher, S. H. & Débarbouillé, M. (2002). Nitrogen source utilization and its regulation. In Bacillus subtilis and its Closest Relatives: from Genes to Cells, pp. 181-191. Edited by A. L. Sonenshein, J. A. Hoch & R. Losick. Washington, DC: American Society for Microbiology.
12. Galinier, A., Haiech, J., Kilhoffer, M.-C., Jaquinod, M., Stülke, J., Deutscher, J. & Martin-Verstraete, I. (1997). The Bacillus subtilis crh gene encodes a HPr-like protein involved in catabolite repression. Proc Natl Acad Sci U S A 94, 8439-8444.
13. Henkin, T. M. (1996). The role of the CcpA transcriptional regulator in carbon metabolism in Bacillus subtilis. FEMS Microbiol Lett 135, 9-15.
14. Jourlin-Castelli, C., Mani, N., Nakano, M. M. & Sonenshein, A. L. (2000). CcpC, a novel regulator of the LysR family required for glucose repression of the citB gene in Bacillus subtilis. J Mol Biol 295, 865-878.
15. Krüger, S., Stülke, J. & Hecker, M. (1993). Catabolite repression of β-glucanase synthesis in Bacillus subtilis. J Gen Microbiol 139, 2047-2054.
16. Kunst, F. & Rapoport, G. (1995). Salt stress is an environmental signal affecting degradative enzyme synthesis in Bacillus subtilis. J Bacteriol 177, 2403-2407.
17. Lindner, C., Stülke, J. & Hecker, M. (1994). Regulation of xylanolytic enzymes in Bacillus subtilis. Microbiology 140, 753-757.
18. Ludwig, H. & Stülke, J. (2001). The Bacillus subtilis catabolite control protein CcpA exerts all its regulatory functions by DNA-binding. FEMS Microbiol Lett 203, 125-129.
19. Ludwig, H., Homuth, G., Schmalisch, M., Dyka, F. M., Hecker, M. & Stülke, J. (2001). Transcription of glycolytic genes and operons in Bacillus subtilis: evidence for the presence of multiple levels of control of the gapA operon. Mol Microbiol 41, 409-422.
20. Ludwig, H., Meinken, C., Matin, A. & Stülke, J. (2002a). Insufficient expression of the ilv-leu operon encoding enzymes of branched-chain amino acid biosynthesis limits growth of a Bacillus subtilis ccpA mutant. J Bacteriol 184, 5174-5178.
21. Ludwig, H., Rebhan, N., Blencke, H.-M., Merzbacher, M. & Stülke, J. (2002b). Control of the glycolytic gapA operon by the catabolite control protein A in Bacillus subtilis: a novel mechanism of CcpA-mediated regulation. Mol Microbiol 45, 543-553.
22. Martin, I., Débarbouillé, M., Klier, A. & Rapoport, G. (1989). Induction and metabolite regulation of levanase synthesis in Bacillus subtilis. J Bacteriol 171, 1885-1892.
23. Miwa, Y., Saikawa, M. & Fujita, Y. (1994). Possible function and some properties of the CcpA protein of Bacillus subtilis. Microbiology 140, 2567-2575.
24. Mogk, A., Homuth, G., Scholz, C., Kim, L., Schmid, F. X. & Schumann, W. (1997). The GroE chaperonin machine is a major modulator of the CIRCE heat shock regulon of Bacillus subtilis. EMBO J 16, 4579-4590.
25. Moreno, M. S., Schneider, B. L., Maile, R. R., Weyler, W. & Saier, M. H., Jr (2001). Catabolite repression mediated by CcpA protein in Bacillus subtilis: novel modes of regulation revealed by whole-genome analyses. Mol Microbiol 39, 1366-1381.
26. Rosenkrantz, M. S., Dingman, D. W. & Sonenshein, A. L. (1985). Bacillus subtilis citB gene is regulated synergistically by glucose and glutamine. J Bacteriol 164, 155-164.
27. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989). Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
28. Schell, M. A. (1993). Molecular biology of the LysR family of transcriptional regulators. Annu Rev Microbiol 47, 597-626.
29. Sonenshein, A. L. (2002). The Krebs citric acid cycle. In Bacillus subtilis and its Closest Relatives: from Genes to Cells, pp. 151-162. Edited by A. L. Sonenshein, J. A. Hoch & R. Losick. Washington, DC: American Society for Microbiology.
30. Stülke, J. & Hillen, W. (2000). Regulation of carbon catabolism in Bacillus species. Annu Rev Microbiol 54, 849-880.
31. Tobisch, S., Zühlke, D., Bernhardt, J., Stülke, J. & Hecker, M. (1999). Role of CcpA in regulation of the central pathways of carbon catabolism in Bacillus subtilis. J Bacteriol 181, 6996-7004.
32. Weinrauch, Y., Msadek, T., Kunst, F. & Dubnau, D. (1991). Sequence and properties of comQ, a new competence regulatory gene of Bacillus subtilis. J Bacteriol 173, 5685-5693.
33. Wray, L. V., Jr, Pettengill, F. K. & Fisher, S. H. (1994). Catabolite repression of the Bacillus subtilis hut operon requires a cis-acting site located downstream of the transcription initiation site. J Bacteriol 176, 1894-1902.
34. Wray, L. V., Jr, Zalieckas, J. M. & Fisher, S. H. (2001). Bacillus subtilis glutamine synthetase controls gene expression through a protein-protein interaction with transcription actor TnrA. Cell 107, 427-435.
35. Yoshida, K.-I., Kobayashi, K., Miwa, Y. & 9 other authors (2001). Combined transcriptome and proteome analysis as a powerful approach to study genes under glucose repression in Bacillus subtilis. Nucleic Acids Res 29, 6683-6692.