Lack of genetic linkage evidence for a trans-acting factor having a large effect on plasma lipoprotein[a] levels in African Americans

Journal of Lipid Research

Volumn 44, Issue 7, 2003, Pages 1301-1305

  Barkley, Ruth Ann ^a   Brown, Andrew C ^b   Hanis, Craig L ^a   Kardia, Sharon L ^c   Turner, Stephen T ^d   Boerwinkle, Eric ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d MAYO CLINIC   (United States)

Author keywords

Genetics; Linkage analysis; Lysophosphatidic acid; Population genetics

Indexed keywords

LIPOPROTEIN A; LYSOPHOSPHATIDIC ACID;

ADULT; AGED; ARTICLE; CHROMOSOME 12; CHROMOSOME 14; CHROMOSOME 19; GENE LOCATION; GENE LOCUS; GENETIC HETEROGENEITY; GENETIC LINKAGE; HUMAN; HUMAN EXPERIMENT; LIPOPROTEIN BLOOD LEVEL; NEGRO; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ADULT; AFRICAN AMERICANS; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 19; EUROPEAN CONTINENTAL ANCESTRY GROUP; HUMANS; LINKAGE (GENETICS); LIPOPROTEIN(A); LOD SCORE; LYSOPHOSPHOLIPIDS; MALE; MIDDLE AGED; TRANS-ACTIVATION (GENETICS);

EID: 0142105891     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M300163-JLR200     Document Type: Article

References (30)

1. Danesh, J., R. Collins, and R. Peto. 2000. Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation. 102: 1082-1085.
2. Sharrett, A. R., C. M. Ballantyne, S. A. Coady, G. Heiss, P. D. Sorlie, D. Catellier, and W. Patsch. 2001. Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: The Atherosclerosis Risk in Communities (ARIC) study. Circulation. 104: 1108-1113.
3. Hahmann, H. W., D. Schatzer-Klotz, T. Bunte, D. Becker, and H. J. Schieffer. 1999. The significance of high levels of lipoprotein (a) compared with established risk factors in premature coronary artery disease: differences between men and women. Atherosclerosis. 144: 221-228.
4. Schaefer, E. J., S. Lamon-Fava, J. L. Jenner, J. R. McNamara, J. M. Ordovas, C. E. Davis, J. M. Abolafia, K. Lippel, and R. I. Levy. 1994. Lipoprotein(a) levels and risk of coronary heart disease in men. The Lipid Research Clinics Coronary Primary Prevention trial. JAMA. 271: 999-1003.
5. Utermann, G. 1989. The mysteries of lipoprotein(a). Science. 246: 904-910.
6. Boerwinkle, E., H. J. Menzel, H. G. Kraft, and G. Utermann. 1989. Genetics of the quantitative Lp(a) lipoprotein trait. III. Contribution of Lp(a) glycoprotein phenotypes to normal lipid variation. Hum. Genet. 82: 73-78.
7. Utermann, G. 1999. Genetic architecture and evolution of the lipoprotein(a) trait. Curr. Opin. Lipidol. 10: 133-141.
8. Guyton, J. R., G. H. Dahlen, W. Patsch, J. A. Kautz, and A. M. Gotto, Jr. 1985. Relationship of plasma lipoprotein Lp(a) levels to race and to apolipoprotein B. Arteriosclerosis. 5: 265-272.
9. Sandholzer, C., D. M. Hallman, N. Saha, G. Sigurdsson, C. Lackner, A. Csaszar, E. Boerwinkle, and G. Utermann. 1991. Effects of the apolipoprotein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic groups. Hum. Genet. 86: 607-614.
10. Srinivasan, S. R., G. H. Dahlen, R. A. Jarpa, L. S. Webber, and G. S. Berenson. 1991. Racial (black-white) differences in serum lipoprotein(a) distribution and its relation to parental myocardial infarction in children. Bogalusa Heart Study. Circulation. 84: 160-167.
11. Gaw, A., E. Boerwinkle, J. C. Cohen, and H. H. Hobbs. 1994. Comparative analysis of the apo(a) gene, apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups. Evidence for no common "null" allele at the apo(a) locus. J. Clin. Invest. 93: 2526-2534.
12. Paultre, F., T. A. Pearson, H. F. Weil, C. H. Tuck, M. Myerson, J. Rubin, C. K. Francis, H. F. Marx, E. F. Philbin, R. G. Reed, and L. Berglund. 2000. High levels of Lp(a) with a small apo(a) isoform are associated with coronary artery disease in African American and white men. Arterioscler. Thromb. Vasc. Biol. 20: 2619-2624.
13. Mooser, V., D. Scheer, S. M. Marcovina, J. Wang, R. Guerra, J. Cohen, and H. H. Hobbs. 1997. The Apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans. Am. J. Hum. Genet. 61: 402-417.
14. The FBPP Investigators. 2002. Multi-center genetic study of hypertension: The Family Blood Pressure Program (FBPP). Hypertension. 39: 3-9.
15. Albers, J. J., J. L. Adolphson, and W. R. Hazzard. 1977. Radioimmunoassay of human plasma Lp(a) lipoprotein. J. Lipid Res. 18: 331-338.
16. Albers, J. J., S. M. Marcovina, and M. S. Lodge. 1990. The unique lipoprotein(a): properties and immunochemical measurement. Clin. Chem. 36: 2019-2026.
17. Almasy, L., and J. Blangero. 1998. Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 62: 1198-1211.
18. Utermann, G., H. J. Menzel, H. G. Kraft, H. C. Duba, H. G. Kemmler, and C. Seitz. 1987. Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma. J. Clin. Invest. 80: 458-465.
19. Scanu, A. M., and G. M. Fless. 1990. Lipoprotein (a). Heterogeneity and biological relevance. J. Clin. Invest. 85: 1709-1715.
20. Cavalli-Sforza, L. L., and W. F. Bodmer. 1971. The Genetics of Human Populations. W. H. Freeman and Company, San Francisco. 965.
21. Pfaff, C. L., E. J. Parra, C. Bonilla, K. Hiester, P. M. McKeigue, M. I. Kamboh, R. G. Hutchinson, R. E. Ferrell, E. Boerwinkle, and M. D. Shriver. 2001. Population structure in admixed populations: effect of admixture dynamics on the pattern of linkage disequilibrium. Am. J. Hum. Genet. 68: 198-207.
22. Willnow, T. E. 1999. The low-density lipoprotein receptor gene family: multiple roles in lipid metabolism. J. Mol. Med. 77: 306-315.
23. Krempler, F., G. M. Kostner, A. Roscher, F. Haslauer, K. Bolzano, and F. Sandhofer. 1983. Studies on the role of specific cell surface receptors in the removal of lipoprotein(a) in man. J. Clin. Invest. 71: 1431-1441.
24. Kostner, G. M., X. Wo, S. Frank, K. Kostner, R. Zimmermann, and E. Steyrer. 1997. Metabolism of Lp(a): assembly and excretion. Clin. Genet. 52: 347-354.
25. Utermann, G., F. Hoppichler, H. Dieplinger, M. Seed, G. Thompson, and E. Boerwinkle. 1989. Defects in the low density lipoprotein receptor gene affect lipoprotein (a) levels: multiplicative interaction of two gene loci associated with premature atherosclerosis. Proc. Natl. Acad. Sci. USA. 86: 4171-4174.
26. Snyder, M. L., R. V. Hay, P. F. Whitington, A. M. Scanu, and G. M. Fless. 1994. Binding and degradation of lipoprotein(a) and LDL by primary cultures of human hepatocytes. Comparison with cultured human monocyte-macrophages and fibroblasts. Arterioscler Thromb. 14: 770-779.
27. Rader, D. J., W. A. Mann, W. Cain, H. G. Kraft, D. Usher, L. A. Zech, J. M. Hoeg, J. Davignon, P. Lupien, M. Grossman, J. M. Wilson, and H. B. J. Brewer. 1995. The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans. J. Clin. Invest. 95: 1403-1408.
28. Myklebost, O., K. Arheden, S. Rogne, A. Geurts van Kessel, N. Mandahl, J. Herz, K. Stanley, S. Heim, and F. Mitelman. 1989. The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14. Genomics. 5: 65-69.
29. Van Leuven, F., E. Thiry, M. Lambrechts, L. Stas, T. Boon, K. Bruynseels, E. Muls, and O. Descamps. 2001. Sequencing of the coding exons of the LRP1 and LDLR genes on individual DNA samples reveals novel mutations in both genes. Atherosclerosis. 154: 567-577.
30. Veniant, M. M., C. H. Zlot, R. L. Walzem, V. Pierotti, R. Driscoll, D. Dichek, J. Herz, and S. G. Young. 1998. Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice. J. Clin. Invest. 102: 1559-1568.