Influence of Simulated Weightlessness on the Oral Pharmacokinetics of Acetaminophen as a Gastric Emptying Probe in Man: A Plasma and a Saliva Study

Journal of Clinical Pharmacology

Volumn 43, Issue 11, 2003, Pages 1235-1243

  Gandia, Peggy ^a   Bareille, Marie Pierre ^a   Saivin, Sylvie ^a   Pavy Le Traon, Anne ^a   Lavit, Michel ^a   Guell, Antonio ^a   Houin, Georges ^a  

^a CHU RANGUEIL   (France)

Author keywords

Acetaminophen pharmacokinetics; Bed rest; Gastric emptying; Simulated weightlessness

Indexed keywords

PARACETAMOL;

ADULT; AREA UNDER THE CURVE; ARTICLE; BED REST; BLOOD; BODY POSTURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG HALF LIFE; DRUG SALIVA LEVEL; HUMAN; HUMAN EXPERIMENT; INTESTINE BLOOD FLOW; MALE; METABOLISM; NONPARAMETRIC TEST; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; SALIVA; SIMULATION; STOMACH EMPTYING; WEIGHTLESSNESS;

ACETAMINOPHEN; ADMINISTRATION, ORAL; ADULT; GASTRIC EMPTYING; HEAD-DOWN TILT; HUMANS; MALE; SALIVA; STATISTICS, NONPARAMETRIC; WEIGHTLESSNESS;

EID: 0142103699     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/0091270003257229     Document Type: Article

References (44)

1. Houin G: Pharmacocinétique. Paris: Ellipse, 1990.
2. Saivin S, Pavy-Le Traon A, Soulez-LaRiviere C, Guell A, Houin G: Pharmacology in space: pharmacokinetics. Adv Space Biol Med 1997;6:107-121.
3. Lathers CM, Charles JB, Bungo MW: Pharmacology in space: Part 2. Controlling motion sickness. Trends Pharmacol Sci 1989;10:243-250.
4. Kakurin LI, Lobachik VI, Mikhailov M, Senkevich YA: Antiorthostatic hypokinesia as a method of weightlessness simulation. Aviat Space Environ Med 1976;47:1083-1086.
5. Nixon JV, Gordon Murray R, Bryant C, Johnson RLJ, Mitchelle JH, Holland OB, et al: Early cardiovascular adaptation to simulated zero gravity. J Appl Physiol 1979;46:541-548.
6. Gaffney FA, Nixon JW, Karlsson ES, Campbell W, Dowdey ABC, Blomqvist CG: Cardiovascular deconditioning produced by 20 hours of bedrest with head-down tilt (-5°) in middle-aged healthy men. Am J Cardiol 1985;56:634-638.
7. Saivin S, Pavy-Le Traon A, Comac A, Guell A, Houin G: Impact of a four-day head-down tilt (-6 degrees) on lidocaine pharmacokinetics used as probe to evaluate hepatic blood flow. J Clin Pharmacol 1995;35:697-704.
8. Kates RE, Harapat SR, Keefe DL, Goldwater D, Harrison DC: Influence of prolonged recumbency on drug disposition. Clin Pharmacol Ther 1980;28:624-628.
9. Renwick AG, Ahsan CH, Challenor VF, Daniels R, Macklin BS, Waller DG, et al: The influence of posture on the pharmacokinetics of orally administered nifedipine. Br J Clin Pharmacol 1992;34:332-336.
10. Villanueva-Meyer J, Swischuk LE, Cesani F, Ali SA, Briscoe E: Pediatric gastric emptying: value of right lateral and upright positioning. J Nucl Med 1996;37:1356-1358.
11. Anvari M, Horowitz M, Fraser R, Maddox A, Myers J, Dent J, et al: Effects of posture on gastric emptying of nonnutrient liquids and antropyloroduodenal motility. Am J Physiol 1995;268:G868-G871.
12. Hunt JN, Smith JL, Jiang CL: Effect of meal volume and energy density on the gastric emptying of carbohydrates. Gastro 1985;89:1326-1330.
13. Cortot A, Phillips SF, Malagelada JR: Gastric emptying of lipids after ingestion of a solid-liquid meal in humans. Gastro 1981;80:922-927.
14. Meyer JH, Ohashi H, Jehn D, Thomson JB: Size of liver particles emptied from the human stomach. Gastro 1981;80:1489-1496.
15. Amidon GL, DeBrincat GA, Najib N: Effects of gravity on gastric emptying, intestinal transit, and drug absorption. J Clin Pharmacol 1991;31:968-973.
16. Rowland M, Tozer TN: Clinical Pharmacokinetics: Concepts and Applications. Philadelphia: Lea & Febiger, 1980.
17. Lathers CM, Charles JB, Bungo MW: Pharmacology in space: Part 1. Influence of adaptive changes on pharmacokinetics. Trends Pharmacol Sci 1989;10:193-200.
18. Lathers CM, Charles JB, Elton KF, Holt TA, Mukai C, Bennett BS, et al: Acute hemodynamic responses to weightlessness in humans. J Clin Pharmacol 1989;29:615-627.
19. Bagnall WE, Kelleher J, Walker BE, Losowsky MS: The gastrointestinal absorption of paracetamol in the rat. J Pharm Pharmacol 1979;31:157-160.
20. Kondo T: Routine gastric emptying tests. J Gastroenterol 2000;35:476-478.
21. Heading RC, Nimmo J, Prescott LF, Tothill P: The dependence of paracetamol absorption on the rate of gastric emptying. Br J Pharmacol 1973;47:415-421.
22. Petring OU, Flachs H: Inter- and intrasubject variability of gastric emptying in healthy volunteers measured by scintigraphy and paracetamol absorption. Br J Pharmacol 1990;29:703-708.
23. Sanaka M, Koike Y, Yamamoto T, Mineshita S, Yamaoka S, Hirama S, et al: A reliable and convenient parameter of the rate of paracetamol absorption to measure gastric emptying rate of liquids. Int J Clin Pharmacol Ther 1997;35:509-513.
24. Sanaka M, Kuyama Y, Nishinakagawa S, Mineshita S: Use of salivary acetaminophen concentration to assess gastric emptying rate of liquids. J Gastroenterol 2000;35:429-433.
25. Doherty TJ, Andrews FM, Provenza MK, Frazier DL: Acetaminophen as a marker of gastric emptying in ponies. Equine Vet J 1998;30:349-351.
26. Lohmann KL, Roussel AJ, Cohen ND, Boothe DM, Rakestraw PC, Walker MA: Comparison of nuclear scintigraphy and acetaminophen absorption as a means of studying gastric emptying in horses. Am J Vet Res 2000;61:310-315.
27. Backon J, Hoffman A: The lateral decubitus position may affect gastric emptying through an autonomic mechanism: the skin pressure-vegetative reflex. Br J Clin Pharmacol 1991;32:138-139.
28. Shah VP, Midha KK, Findlay JW, Hill HM, Hulse JD, McGilveray IJ, et al: Bioanalytical method validation-a revisit with a decade of progress. Pharm Res 2000;17:1551-1557.
29. Lellouch J, Lazar P: Méthodes statistiques en expé rimentation biologique. Paris: Flammarion, 1996.
30. Santy PA, Bungo MW: Pharmacologic considerations for shuttle astronauts. J Clin Pharmacol 1991;31:931-933.
31. Nicogossian AE, Dietlein L: Microgravity simulations and analogs, in: Nicogossian AE, Leach-Huntoon C, Pool SL (eds.), Space Physiology and Medicine. Philadelphia: Lea & Febiger, 1994;240-248.
32. Gharib C, Gauquelin G, Pequignot JM, Geelen G, Bizollon CA, Guell A: Early hormonal effects of head-down tilt (-10 degrees) in humans. Aviat Space Environ Med 1988;59:624-629.
33. Rumble RH, Roberts MS, Denton MJ: Effects of posture and sleep on the pharmacokinetics of paracetamol (acetaminophen) and its metabolites. Clin Pharmacokin 1991;20:167-173.
34. Lathers CM, Charles JB, Bungo MW: Humans in space: NASN's contributions to medical technology and health care. J Clin Pharmacol 1990;30:223-225.
35. Mulvagh SL, Charles JB, Riddle JM, Rehbein TL, Bungo MW: Echographic evaluation of the cardiovascular effects of short-duration spaceflight. J Clin Pharmacol 1991;31:1024-1026.
36. Bassett Frey MA, Tomaselli CM, Hoffler WG: Cardiovascular responses to postural changes: differences with age for women and men. J Clin Pharmacol 1994;34:394-402.
37. Smith JJ, Porth CM, Erickson M: Hemodynamic response to the upright posture. J Clin Pharmacol 1994;34:375-386.
38. Lathers CM, Diamandis PH, Riddle JM, Mukai C, Elton KF, Bungo MW, et al: Acute and intermediate cardiovascular responses to zero gravity and to fractional gravity levels induced by head-down or head-up tilt. J Clin Pharmacol 1990;30:494-523.
39. Lathers CM, Riddle JM, Mulvagh SL, Mukai C, Diamandis PH, Dussack LG, et al: Echocardiograms during six hours of bedrest at head-down and head-up tilt and during space flight. J Clin Pharmacol 1993;33:535-543.
40. Lathers CM, Diamandis PH, Riddle JM, Mukai C, Elton KF, Bungo MW, et al: Orthostatic function during a stand test before and after head-up or head-down bed-rest. J Clin Pharmacol 1991;31:893-903.
41. Rawlins MD, Henderson DB, Hijab AR: Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration. Eur J Clin Pharmacol 1977;11:283-286.
42. Cintron NM, Putcha L, Vanderploeg JM: Inflight pharmacokinetics of acetaminophen in saliva, in: Bungo MW, Bagian TM, Bowman MA, Levitan BM (eds.), Results of the Life Sciences DSOs Conducted aboard the Space Shuttle 1981-1986. Houston, TX: Space Biomedical Research Institute, Johnson Space Center, 1987;19-23.
43. Smith M, Whitehead E, O'Sullivan G, Reynolds F: A comparison of serum and saliva paracetamol concentrations. Br J Pharmacol 1991;31:553-555.
44. Kamali F, Fry JR, Bell GD: Salivary secretion of paracetamol in man. J Pharm Pharmacol 1987;39:150-152.