Fibrinogen Otsu I:A γAsn319,Asp320 deletion dysfibrinogen identified in an asymptomatic pregnant woman

Thrombosis and Haemostasis

Volumn 90, Issue 4, 2003, Pages 757-758

  Terasawa, Fumiko ^b   Hogan, Kelly A ^b   Kani, Satomi ^b   Hirose, Masaya ^b   Eguchi, Yutaka ^b   Noda, Yoichi ^b   Hongo, Minoru ^b   Okumura, Nobuo ^a  

^a SHINSHU UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; ASPARTIC ACID; DNA FRAGMENT; FIBRINOGEN; FIBRINOGEN OTSU; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; CASE REPORT; CHEMICAL ANALYSIS; CHILDBIRTH; CONTROLLED STUDY; DENSITOMETRY; DYSFIBRINOGENEMIA; EXON; FEMALE; FIBRIN POLYMERIZATION; FIBRINOGEN BLOOD LEVEL; FIBRINOGEN OTSU I; GENE DELETION; GENETIC ANALYSIS; HETEROZYGOSITY; HOSPITAL ADMISSION; HUMAN; IMMUNOBLOTTING; INFORMED CONSENT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREGNANCY; PRIORITY JOURNAL; SERODIAGNOSIS; SYMPTOMATOLOGY; THROMBIN TIME; TOXEMIA;

EID: 0142060996     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/th03-04-0201     Document Type: Article

References (7)

1. http://www.geht.org/pages/database_fibrino_uk.html
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3. Haverkate S, Samama M. Familial dysfibrinogenemia and thrombophilia. Report on a study of the SSC subcommittee on fibrinogen. Thromb Haemost 1995; 73: 151-61.
4. Terasawa F, Okumura N, Kitano K, et al. Hypofibrinogenemia associates with a heterozygous missense mutation γ153Cys to Arg (Matsumoto IV): In vitro expression demonstrates defective secretion of the variant fibrinogen. Blood 1999; 94: 4122-31.
5. Okumura N, Gorkun OV, Lord ST. Severely impaired polymerization of recombinant fibrinogen γ-364 Asp→His, the substitution discovered in a heterozygous individual. J Biol Chem 1997; 272: 29596-601.
6. Hogan KA, Gorkun OV, Lounes KC, et al. Recombinant fibrinogen Vlissingen/Frankfurt IV. J Biol Chem 2000; 275: 17778-85.
7. Hogan KA, Lord ST, Okumura N, et al. A functional assay suggests that heterodimers exist in two C-terminal γ-chain dysfibrinogens: Matsumoto I and Vlissingen/Frankfurt IV. Thromb Haemost 2000; 83: 592-5.