Studies on the pharmacology of the novel histamine H3 receptor agonist Sch 50971

Arzneimittel-Forschung/Drug Research

Volumn 48, Issue 9, 1998, Pages 881-888

  Hey, John A ^a   Aslanian, Robert ^a   Bolser, Donald C ^a   Chapman, Richard W ^a   Egan, Robert W ^a   Rizzo, Charles A ^a   Shih, Neng Yang ^a   Fernandez, Xiomara ^a   McLeod, Robbie L ^a   West, Robert ^a   Kreutner, William ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

(+) trans 4 (4(R) Methyl 3(R) pyrolidinyl) 1H imidazole dihydrochloride; (R) Methylhistamine; CAS 167610 28 8; CAS 75614 87 8; Histamine H3 receptors, agonists; Sch 50971, pharmacology, prejunctional inhibition, sympathoinhibition

Indexed keywords

4 (4 METHYL 3 PYRROLIDINYL) 1H IMIDAZOLE; ALPHA METHYLHISTAMINE; HISTAMINE; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR AGONIST; PENTOBARBITAL; THIOPERAMIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CAT; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GUINEA PIG; HUMAN; HUMAN TISSUE; HYPERTENSION; ILEUM CONTRACTION; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; NORADRENALIN RELEASE; NOSE AIRWAY RESISTANCE; PLETHYSMOGRAPHY; PRESYNAPTIC INHIBITION; PULMONARY ARTERY; RESPIRATION DEPRESSION; SYMPATHETIC NERVE;

AIRWAY RESISTANCE; ANIMALS; ATRIAL FUNCTION; BLOOD PRESSURE; BRAIN; BRONCHOCONSTRICTOR AGENTS; CATS; GUINEA PIGS; HEART ATRIA; HISTAMINE AGONISTS; HUMANS; ILEUM; IMIDAZOLES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NOREPINEPHRINE; PULMONARY ARTERY; PYRROLIDINES; RATS; RECEPTORS, DOPAMINE; RECEPTORS, HISTAMINE H1; RECEPTORS, HISTAMINE H3; RECEPTORS, MUSCARINIC; RECEPTORS, SEROTONIN; RESPIRATORY MECHANICS;

EID: 0142060360     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Arrang, J.-M., Garbarg, M., Schwartz, J.-C., Nature 302, 832 (1983)
2. Ishikawa, S., Sperelakis, N., Nature 327, 158 (1987)
3. Arrang, J.-M., Devaux, B., Chodkiewicz, J. P. et al., Neurochem. 51, 105 (1988)
4. Schlicker, E., Betz, R., Göthert, M., Naunyn-Schmiedeberg's Arch. Pharmacol. 337, 588 (1988)
5. Schlicker, E., Betz, R., Göthert, M., Naunyn-Schmiedeberg's Arch. Pharmacol. 324, 497 (1990)
6. Clapham, J., Kilpatrick, G. J., Br. J. Pharmacol. 107, 919 (1992)
7. Ichinose, M., Stretton, C. D., Schwartz, J.-C. et al., Br. J. Pharmacol. 94, 13 (1989)
8. Ichinose, M., Barnes, P. J., Eur. J. Pharmacol. 174, 48 (1989)
9. Trzeciakowski, J. P., J. Pharmacol. Exp. Ther. 243, 874 (1987)
10. Coruzzi, G., Poli, E., Bertaccini, G., J. Pharmacol. Exp. Ther. 258, 325 (1991)
11. West, Jr., R. E., Zweig, A., Shih, N. Y. et al., Mol. Pharmacol. 38, 610 (1990)
12. Boiser, D. C., Blythin, D. J., Chapman, R. W. et al., J. Pharmacol. Exp. Ther. 274, 1393 (1995)
13. Tran, V. T., Chang, R. L. S., Snyder, S. H., Proc. Natl. Acad. Sci. 75, 6290 (1978)
14. Smith, P. K., Krohn, R. I., Hermanson, G. T. et al., Anal. Biochem. 150, 77 (1985)
15. Billard, W., Ruperto, V. Crosby, G. et al., Life Sci. 35, 1885 (1984)
16. McQuade, R. D., Ford, D., Duffy, R. A. et al., Life Sci. 43, 1861 (1988)
17. Watson, M., Yamamura, H. I., Roeske, W. R., J. Pharmacol. Exp. Ther. 237, 411 (1986)
18. Vollinga, R. C., Zuiderveld, O. P., Scheerens, H. et al., Meth. Find. Exp. Clin. Pharmacol. 14, 747 (1992)
19. Furchgott, R. F., Pharm. Rev. 7, 183 (1955)
20. Hey, J. A., del Prado, M., Egan, R. W. et al., Br. J. Pharmacol. 107, 347 (1992)
21. Hey, J. A., del Prado, M., Egan, R. W. et al., Pul. Pharmacol. 3, 53 (1990)
22. Danko, G., Chapman, R. W., J. Pharmacol. Methods 19, 165 (1988)
23. Eccles, R., Wilson, H., J. Physiol. 238, 549 (1974)
24. Hey, J. A., del Prado, M., Egan, R. W. et al., Eur. J. Pharmacol. 211, 421 (1992)
25. Van der Werf, J. F., Bast, A., Bijloo, G. J. G. et al., Eur. J. Pharmacol. 138, 1199 (1987)
26. Fink, K., Schlicker, E., Neise, A., Göthert, M., Naunyn-Schmiedeberg's Arch. Pharmacol. 342, 513 (1990)
27. Schwartz, J. C., Arrang, J. M., Garbarg, M. et al., Physiol. Rev. 71, 1 (1991)
28. Schlicker, E., Fink, K., Detzner, M., et al., J. Neural. Trans. 93, 1 (1993)
29. Poli, E., Coruzzi, G., Bertaccini, G., Life Sci. 48, 63 (1991)
30. Molderings, G. J., Weßenborn, G., Schlicker, E. et al., Naunyn-Schmiedeberg's Arch. Pharmacol. 346, 46 (1992)
31. Kavanagh, G. M., Sabroe, R. A., Greaves, M. W. et al., Br. J. Dermatol. 138, 622 (1998)