Stereoselective bioreduction to a chiral building block on a kilogram scale

Chimia

Volumn 57, Issue 9, 2003, Pages 574-576

  Jablonski Lorin, Christelle ^a   Melillo, Vito ^b   Hungerbühler, Ernst ^a  

^a UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

^b SynphaBase AG   (Switzerland)

Author keywords

Biotransformation; High stereoselectivity; S. pombe yeast; Scale up process; Wavebioreactor

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; ETHYL 2 HYDROXYCYCLOHEXANE CARBOXYLATE; ETHYLCYCLOHEXANONE 2 CARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; BIOREACTOR; BIOTRANSFORMATION; CELL GROWTH; CHIRALITY; DIASTEREOISOMER; ENANTIOMER; HUMAN; PURIFICATION; REDUCTION; STEREOCHEMISTRY; STUDENT;

EID: 0142057517     PISSN: 00094293     EISSN: None     Source Type: Journal    
DOI: 10.2533/000942903777678894     Document Type: Article

References (5)

1. R.E. Gawley, J. Aubé, in 'Principles of Asymmetric Synthesis', Tetrahedron Organic Chemistry Series, Vol. 14, Ed. Pergamon, 1996.
2. M. Bertau, M. Bürli, E. Hungerbühler, Chimica Oggi 1998, 58-61.
3. M. Bertau, M. Bürli, E. Hungerbühler, BioworId 1999, 1, 7-10.
4. M. Bertau, M. Bürli, E. Hungerbühler, P. Wagner, Tetrahedron Asymmetr, 2001, 12, 2103-2107.
5. The reduction of β-ketoesters with the Noyori catalyst led also to the corresponding hydroxyester with a high stereoselectivity - e.g. the ethyl (1S,2S)-trans-2-hydroxycyclopentane carboxylate was synthesized with a dr and an er higher than 99:1.