Occupational methaemoglobinaemia: Mechanisms of production, features, diagnosis and management including the use of methylene blue

Toxicological Reviews

Volumn 22, Issue 1, 2003, Pages 13-27

  Bradberry, Sally M ^a  

^a CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANILINE DERIVATIVE; AROMATIC COMPOUND; ASCORBIC ACID; CHLORATE; FERRIC ION; FERROUS ION; HEMOGLOBIN; METHEMOGLOBIN; METHYLENE BLUE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITRATE; NITRITE; NITROBENZENE DERIVATIVE; NITROGEN OXIDE; OXYGEN; TOCOPHEROL;

ABDOMINAL PAIN; ABSORPTION; ANXIETY; BIOTRANSFORMATION; BLOOD CARBON DIOXIDE TENSION; BLOOD GAS ANALYSIS; BLOOD OXYGEN TENSION; CLINICAL FEATURE; CLINICAL OBSERVATION; CLINICAL TRIAL; CONFUSION; CYANOSIS; DRUG ABSORPTION; DRUG CONTRAINDICATION; DRUG EFFICACY; DRUG ELIMINATION; DRUG INDICATION; DRUG MECHANISM; DRUG MEGADOSE; ECG ABNORMALITY; ERYTHROCYTE; EXCHANGE BLOOD TRANSFUSION; FATALITY; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HEADACHE; HEMATOLOGIC DISEASE; HEMOGLOBIN DETERMINATION; HEMOLYSIS; HUMAN; INHALATION; INTOXICATION; INTRAVASCULAR HEMOLYSIS; LIPOPHILICITY; METABOLIC ACIDOSIS; METHEMOGLOBINEMIA; MYDRIASIS; NAUSEA; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL TOXICOLOGY; OXIDATION; OXYGEN THERAPY; PAIN; PARESTHESIA; PATHOGENESIS; PULSE OXIMETRY; REVIEW; SIDE EFFECT; SKIN; STAINING; SUPPLEMENTATION; SUPPORT GROUP; TACHYCARDIA; TACHYPNEA; THORAX PAIN; TOXICOKINETICS; TREMOR; VERTIGO; VOMITING; WORKPLACE;

ENZYME INHIBITORS; HUMANS; METHEMOGLOBINEMIA; METHYLENE BLUE; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE;

EID: 0142057165     PISSN: 11762551     EISSN: None     Source Type: Journal    
DOI: 10.2165/00139709-200322010-00003     Document Type: Review

References (91)

1. Bunn HF, Forget BG. Hemoglobin Oxidation: Methemoglobin, Methemoglobinemia and Sulfhemoglobinemia. In: Hemoglobin: Molecular, Genetic and Clinical Aspects. Philadelphia (PA): WB Saunders, 1986: 634-62
2. Eyer P, Klimmek R. Blood and blood-forming organs. In: Marquardt H, Schäfer SG, McClellan RO, et al., editors. Toxicology. San Diego (CA): Academic Press, 1999: 349-69
3. Kiese M. The biochemical production of ferrihemoglobin-forming derivatives from aromatic amines, and mechanisms of ferrihemoglobin formation. Pharmacol Rev 1966; 18: 1091-161
4. Liao Y-P, Hung D-Z, Yang D-Y. Hemolytic anemia after methylene blue therapy for aniline-induced methemoglobinemia. Vet Hum Toxicol 2002; 44: 19-21
5. Holstege C, Snyder L, Cisek J, et al. Profound methemoglobinemia induced by dermal and inhalation exposure to aniline dye [abstract]. J Toxicol Clin Toxicol 1999; 37: 621
6. Demirel H, Koster VS, Koot MJ, et al. Methemoglobinemia as an uncommon cause of cyanosis. Neth J Med 1999; 55: 19-22
7. Phillips DM, Gradisek R, Heiselman DE. Methemoglobinemia secondary to aniline exposure. Ann Emerg Med 1990; 19: 425-9
8. Harvey JW, Keitt AS. Studies of the efficacy and potential hazards of methylene blue therapy in aniline-induced methaemoglobinaemia. Br J Haematol 1983; 54: 29-41
9. Sekimpi DK, Jones RD. Notifications of industrial chemical cyanosis poisoning in the United Kingdom 1961-80. Br J Ind Med 1986; 43: 272-9
10. Harrison MR. Toxic methaemoglobinaemia: A case of acute nitrobenzene and aniline poisoning treated by exchange transfusion. Anaesthesia 1977; 32: 270-2
11. Wuertz RL, Frazee Jr WH, Hume WG, et al. Chemical cyanosis-anemia syndrome: Diagnosis, treatment and recovery. Arch Environ Health 1964; 9: 478-91
12. Morse DL, Baker Jr EL, Kimbrough RD, et al. Propanil-chloracne and methomyl toxicity in workers of a pesticide manufacturing plant. J Toxicol Clin Toxicol 1979; 15: 13-21
13. Kulkarni BS, Archarya VN, Khanna RM, et al. Methemoglobinemia due to nitro-aniline intoxication: Review of the literature with a report of 9 cases. J Postgrad Med 1969; 15: 192-200
14. Jain SM, Dilipkumar BS, Kakrani AL. Aniline dye poisoning. J Indian Med Assoc 1975; 65: 51-2
15. Laure P, Stierle F. Methaemoglobinaemia: An unusual case report [letter]. Intensive Care Med 1993; 19: 124
16. NIOSH. Methemoglobinemia due to occupational exposure to dinitrobenzene: Ohio, 1986. Arch Dermatol 1988; 124: 1171-2
17. Ishihara N, Kanaya A, Ikeda M. m-Dinitrobenzene intoxication due to skin absorption. Int Arch Occup Environ Health 1976; 36: 161-8
18. Kokal KC, Khanna SS, Retnam VJ, et al. Methemoglobinaemia: An unusual presentation. J Assoc Physicians India 1984; 32: 833-4
19. Minami M, Katsumata M, Tomoda A. Methemoglobinemia with oxidized hemoglobins and modified hemoglobins found in bloods of workers handling aromatic compounds and in those of a man who drank cresol solution. Biomedica Biochimica Acta 1990; 49: S327-33
20. El-Waseef A. Methemoglobinemia in workers exposed to some aromatic compounds. Pakistan J Biochem 1982; 15: 76-82
21. Johnson PN, Sullivan FM, Lewander WJ. Methemoglobinemia following occupational exposure to sodium betanaphthol disulfonate (R salt) [abstract]. Vet Hum Toxicol 1987; 29: 460
22. Iserson KV, Banner W, Froede RC, et al. Failure of dialysis therapy in potassium dichromate poisoning. J Emerg Med 1983; 1: 143-9
23. Beer ST, Bradberry SM, Vale JA. Copper sulphate. UKPID monograph. In: IPCS Intox CD ROM. Geneva: World Health Organization, 2000
24. Harris JC, Rumack BH, Peterson RG, et al. Methemoglobinemia resulting from absorption of nitrates. JAMA 1979; 242: 2869-71
25. Bradberry SM, Gazzard B, Vale JA. Methemoglobinemia caused by the accidental contamination of drinking water with sodium nitrite. J Toxicol Clin Toxicol 1994; 32: 173-8
26. Fleetham JA, Tunnicliffe BW, Munt PW. Methemoglobinemia and the oxides of nitrogen N Engl J Med [letter]. 1978; 298: 1150
27. Wax PM, Hoffman RS. Methemoglobinemia: An occupational hazard of phenylpropanolamine production. J Toxicol Clin Toxicol 1994; 32: 299-303
28. Shults WT, Fountain EN, Lynch EC. Methanethiol poisoning: Irreversible coma and hemolytic anemia following inhalation. JAMA 1970; 211: 2153-4
29. Kosaka H, Tyuma I. Mechanism of autocatalytic oxidation of oxyhemoglobin by nitrite. Environ Health Perspect 1987; 73: 147-51
30. Arduini A, Mancinelli G, Radatti GL, et al. Possible mechanism of inhibition of nitrite-induced oxidation of oxyhemoglobin by ergothioneine and uric acid. Arch Biochem Biophys 1992; 294: 398-402
31. Kiese M. Methemoglobinemia: A Comprehensive Treatise. Causes, Consequences, and Correction of Increased Contents of Ferrihemoglobin in Blood. Cleveland (OH): CRC Press, 1974
32. Mclean S, Starner GA, Thomas J. Methaemoglobin formation by aromatic amines. J Pharm Pharmacol 1969; 21: 441-50
33. Benya TJ, Cornish HH. Aromatic nitro and amino compounds. In: Clayton GD, Clayton FE, editors. Patty's Industrial Hygiene and Toxicology. 4th ed. New York: John Wiley & Sons, 1994: 947-1085
34. Cnubben NH, Soffers EM, Peters MA, et al. Influence of the halogen-substituent pattern of fluoronitrobenzenes on their biotransformation and capacity to induce methemoglobinemia. Toxicol Appl Pharmacol 1996; 139: 71-83
35. Hoffman RS, Sauter D. Methemoglobinemia resulting from smoke inhalation. Vet Hum Toxicol 1989; 31: 168-70
36. Heyndrickx A, Van Steenberge M. Methemoglobinemia in patients attacked by chemical and microbiological warfare agents. Arch Belg 1984; Suppl.: 69-73
37. Chikhalikar AA, Golwalla AF, Shah AB. Acute toxic methemoglobinemia in industrial workers: A medical emergency. J Assoc Physicians India 1977; 25: 233-6
38. Bradberry SM, Whittington RM, Patty DA et al. Fatal methemoglobinemia due to inhalation of isobutyl nitrite. J Toxicol Clin Toxicol 1994; 32: 179-84
39. Lee DBN, Brown DL, Baker LRI, et al. Hematological complications of chlorate poisoning. BMJ 1970; 2: 31-2
40. O'Grady J, Jarecsni E. Sodium chlorate poisoning. Br J Clin Pract 1971; 25: 38-9
41. Reay DT, Insalaco SJ, Eisele JW. Postmortem methemoglobin concentrations and their significance. J Forensic Sci 1984; 29: 1160-3
42. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: Etiology, pharmacology, and clinical management. Ann Emerg Med 1999; 34: 646-56
43. Geiger JC. Cyanide poisoning in San Francisco. JAMA 1932; 99: 1944-5
44. Hanzlik PJ. Methylene blue as antidote for cyanide poisoning [letter]. JAMA 1933; 100: 357
45. Williams JR, Challis FE. Methylene blue as an antidote for aniline dye poisoning: Case report with confirmatory experimental study. J Lab Clin Med 1933; 19: 166-71
46. Wendel WB. The control of methemoglobinemia with methylene blue. J Clin Invest 1939; 18: 179-85
47. Bodansky O, Gutmann H. Treatment of methemoglobinemia. J Pharm Exp Ther 1947; 89: 46-56
48. Gutmann HR, Jandorf BJ, Bodansky O. The role of pyridine nucleotides in the reduction of methemoglobin. J Biol Chem 1947; 169: 145-52
49. Bodansky O. Mechanism of action of methylene blue in treatment of methemoglobinemia [letter]. JAMA 1950; 142: 923
50. Sass MD, Caruso CJ, Axelrod DR. Mechanism of the TPNH-linked reduction of methemoglobin by methylene blue. Clin Chim Acta 1969; 24: 77-85
51. Tomoda A, Ida M, Tsuji A, et al. Mechanism of methaemoglobin reduction by human erythrocytes. Biochem J 1980; 188: 535-40
52. Di Santo AR, Wagner JG. Pharmacokinetics of highly ionised drugs II. Methylene blue: Absorption, metabolism and excretion in man and dog after oral administration. J Pharm Sci 1972; 61: 1086-90
53. Di Santo AR, Wagner JG. Pharmacokinetics of highly ionised drugs III. Methylene blue: Blood levels in the dog and tissue levels in the rat following intravenous administration. J Pharm Sci 1972; 61: 1090-4
54. Nathan DM, Siegel AJ, Bunn HF. Acute methemoglobinemia and hemolytic anemia with phenazopyridine: Possible relation to acute renal failure. Arch Intern Med 1977; 137: 1636-8
55. Zimmerman RC, Green ED, Ghurabi WH, et al. Methemoglobinemia from overdose of phenazopyridine hydrochloride. Ann Emerg Med 1980; 9: 147-9
56. Spielman FJ, Anderson JA, Terry WC. Benzocaine-induced methemoglobinemia during general anesthesia. J Oral Maxillofac Surg 1984; 42: 740-3
57. Foxworth JW, Roberts JA, Mahmoud SF. Acquired methemoglobinemia: A case report. Mo Med 1987; 84: 187-9
58. Wilson G, Borthwick T, Lamb R. Toxic methemoglobinemia. J Tenn Med Assoc 1989; 82: 581-3
59. Sandza Jr JG, Roberts RW, Shaw RC, et al. Symptomatic methemoglobinemia with a commonly used topical anesthetic, cetacaine. Ann Thorac Surg 1980; 30: 187-90
60. Guss DA, Normann SA, Manoguerra AS. Clinically significant methemoglobinemia from inhalation of isobutyl nitrite. Am J Emerg Med 1985; 3: 46-7
61. Ferraro L, Zeichner S, Greenblott G, et al. Cetacaine-induced acute methemoglobinemia. Anesthesiology 1988; 69: 614-5
62. Fincher ME, Campbell HT. Methemoglobinemia and hemolytic anemia after phenazopyridine hydrochloride (pyridium) administration in end-stage renal disease. South Med J 1989; 82: 372-4
63. Bardoczky GI, Wathieu M, D'Hollander A. Prilocaine-induced methemoglobinemia evidenced by pulse oximetry. Acta Anaesthesiol Scand 1990; 34: 162-4
64. Caudill L, Walbridge VJ, Kuhn G. Methemoglobinemia as a cause of coma. Ann Emerg Med 1990; 19: 677-9
65. Grum DF, Rice TW. Methemoglobinemia from topical benzocaine. Cleve Clin J Med 1990; 57: 357-9
66. White CD, Weiss LD. Varying presentations of methemoglobinemia: Two cases. J Emerg Med 1991; 9: 45-9
67. Bhutani A, Bhutani MS, Patel R. Methemoglobinemia in a patient undergoing gastrointestinal endoscopy. Ann Pharmacother 1992; 26: 1239-40
68. McKinney CD, Postiglione KF, Herold DA. Benzocaine-adulterated street cocaine in association with methemoglobinemia. Clin Chem 1992; 38: 596-7
69. Muchmore EA, Dahl BJ. One blue man with mucositis [letter]. N Engl J Med 1992; 327: 133
70. Cline MS. Curing the 'nitrate blues'. Postgrad Med 1994; 96: 124-6
71. Hornfeldt CS, Rabe III WH. Nitroethane poisoning from an artificial fingernail remover. J Toxicol Clin Toxicol 1994; 32: 321-4
72. Rodriguez LF, Smolik LM, Zbehlik AJ. Benzocaine-induced methemoglobinemia: Report of a severe reaction and review of the literature. Ann Pharmacother 1994; 28: 643-9
73. Hovenga S, Koenders MEF, Van Der Werf TS, et al. Methaemoglobinaemia after inhalation of nitric oxide for treatment of hydrochlorothiazide-induced pulmonary oedema. Lancet 1996; 348: 1035-6
74. Kearney TE, Manoguerra AS, Dunford Jr JV. Chemically induced methemoglobinemia from aniline poisoning. West J Med 1984; 140: 282-6
75. Wendel WB. Use of methylene blue in methemoglobinemia from sulfanilamide poisoning [letter]. JAMA 1937; 109: 1216
76. Kohn MC, Melnick RL, Ye F, et al. Pharmacokinetics of sodium nitrite-induced methemoglobinemia in the rat. Drug Metab Dispos 2002; 30: 676-83
77. Goldstein BD. Exacerbation of dapsone-induced Heinz body hemolytic anemia following treatment with methylene blue. Am J Med Sci 1974; 267: 291-7
78. Stossel TP, Jennings RB. Failure of methylene blue to produce methemoglobinemia in vivo. Am J Clin Pathol 1966; 45: 600-4
79. Goluboff N, Wheaton R. Methylene blue induced cyanosis and acute hemolytic anemia complicating the treatment of methemoglobinemia. J Pediatr 1961; 58: 86-9
80. Sills MR, Zinkham WH. Methylene blue-induced Heinz body hemolytic anemia. Arch Pediatr Adolesc Med 1994; 148: 306-10
81. Rosen PJ, Johnson C, McGehee WG, et al. Failure of methylene blue treatment in toxic methemoglobinemia: Association with glucose-6-phosphate dehydrogenase deficiency. Ann Intern Med 1971; 75: 83-6
82. Smith RP, Thron CD. Hemoglobin, methylene blue and oxygen interactions in human red cells. J Pharmacol Exp Ther 1972; 183: 549-58
83. Eysseric H, Vincent F, Peoc'h M, et al. A fatal case of chlorate poisoning: Confirmation by ion chromatography of body fluids. J Forensic Sci 2000; 45: 474-7
84. Steffen C, Wetzel E. Chlorate poisoning: Mechanism of toxicity. Toxicology 1993; 84: 217-31
85. Smith RP, Olson MV. Drug-induced methemoglobinemia. Semin Hematol 1973; 10: 253-68
86. Layne WR, Smith RP. Methylene blue uptake and the reversal of chemically induced methemoglobinemias in human erythrocytes. J Pharmacol Exp Ther 1969; 165: 36-44
87. Hartmann AF, Perley AM, Barnett HL. A study of some of the physiological effects of sulfanilamide II. Methemoglobin formation and its control. J Clin Invest 1938; 17: 699-710
88. Perry PM, Meinhard E. Necrotic subcutaneous abscesses following injections of methylene blue. Br J Clin Pract 1974; 28: 289-91
89. Nadler JE, Green H, Rosenbaum A. Intravenous injection of methylene blue in man with reference to its toxic symptoms and effect on the electrocardiogram. Am J Med Sci 1934; 188: 15-21
90. Whitwam JG, Taylor AR, White JM. Potential hazard of methylene blue. Anaesthesia 1979; 34: 181-2
91. Schleifer WF, Chapin JW, Cuka DJ, et al. Methylene blue and pulse oximeter readings in a patient undergoing transurethral procedure. Urology 1990; 36: 537-8