Development of Resistance to Acyclovir during Chronic Infection with the Oka Vaccine Strain of Varicella-Zoster Virus, in an Immunosuppressed Child

Journal of Infectious Diseases

Volumn 188, Issue 7, 2003, Pages 954-959

  Levin, Myron J ^a   Dahl, Karen M ^a   Weinberg, Adriana ^a   Giller, Roger ^a   Patel, Amita ^b   Krause, Philip R ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTINEOPLASTIC AGENT; CHICKENPOX VACCINE; FOSCARNET; THYMIDINE KINASE; VARICELLA ZOSTER VACCINE; VIRUS DNA; VIRUS ENZYME;

ANTIBIOTIC RESISTANCE; ARTICLE; CANCER CHEMOTHERAPY; CASE REPORT; CLINICAL FEATURE; DISEASE COURSE; GENE MUTATION; GENERAL CONDITION IMPROVEMENT; HERPES ZOSTER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNE DEFICIENCY; LABORATORY TEST; LUMBAR PUNCTURE; MALE; NEUROBLASTOMA; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; SKIN BIOPSY; STEM CELL TRANSPLANTATION; VACCINATION REACTION; VARICELLA ZOSTER VIRUS;

ABDOMINAL NEOPLASMS; ACYCLOVIR; ANTIVIRAL AGENTS; CHICKENPOX VACCINE; DNA, VIRAL; DRUG RESISTANCE, VIRAL; FOSCARNET; HERPES ZOSTER; HERPESVIRUS 3, HUMAN; HUMANS; INFANT; MALE; NEUROBLASTOMA; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; VACCINATION; VACCINES, ATTENUATED;

EID: 0142042465     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/378502     Document Type: Article

References (36)

1. Feldman S, Hughes WT, Daniel CB. Varicella in children with cancer: seventy-seven cases. Pediatrics 1975; 56:388-97.
2. Atkinson K, Meyers JD, Storb R, Prentice RL, Thomas ED. Varicella-zoster virus infection after marrow transplantation for aplastic anemia or leukemia. Transplantation 1980; 29:47-50.
3. Feldhoff CM, Balfour HH, Simmons RL, Najarian JS, Mauer SM. Varicella in children with renal transplants. J Pediatr 1981; 98:25-31.
4. Morgan ER, Smalley LA. Varicella in immunocompromised children: incidence of abdominal pain and organ involvement. Am J Dis Child 1983; 137:883-5.
5. Feldman S, Lott L. Varicella in children with cancer: impact of antiviral therapy and prophylaxis. Pediatrics 1987; 80:465-72.
6. Perrone C, Lazanas M, Leport C, et al. Varicella in patients infected with the human immunodeficiency virus. Arch Dermatol 1990; 126:1033-6.
7. von Seidlein L, Gillette SG, Bryson Y, et al. Frequent recurrence and persistence of varicella-zoster virus infections in children infected with human immunodeficiency virus type 1. J Pediatr 1996; 128:52-7.
8. Derryck A, LaRussa P, Steinberg S, Capasso M, Pitt J, Gershon AA. Varicella and zoster in children with human immunodeficiency virus infection. Pediatr Infect Dis J 1998; 17:931-2.
9. Srugo I, Israele V, Wittek AE, Courville T, Vimal VM, Brunell PA. Clinical manifestations of varicella-zoster virus infections in human immunodeficiency virus-infected children. Am J Dis Child 1993; 147:742-5.
10. Hoppenjans WB, Bibler MR, Orme RL, Solinger AM. Prolonged cutaneous herpes zoster in acquired immunodeficiency syndrome. Arch Dermatol 1990; 126:1048-50.
11. Nikkels AF, Snoeck R, Rentier B, Pierard GE. Chronic verrucous varicella zoster virus skin lesions: clinical, histological, molecular and therapeutic aspects. Clin Exp Dermatol 1999; 24:346-53.
12. Crassard N, Souillet AL, Morfin F, Thouvenot D, Claudy A, Bertrand Y. Acyclovir-resistant varicella infection with atypical lesions in a non-HIV leukemic infant. Acta Paediatr 2000; 89:1497-9.
13. Leibovitz E, Kaul A, Rigaud M, Bebenroth D, Krasinski K, Borkowsky W. Chronic varicella zoster in a child infected with human immunodeficiency virus: case report and review of the literature. Cutis 1992; 49: 27-31.
14. Veraldi S, Gnecchi L, Zorzi F. Verrucous-crusted herpes zoster in an immunocompetent patient. Acta Derm Venereol 1998; 78:236-7.
15. Pawha S, Biron K, Lim W, et al. Continuous varicella-zoster infection associated with acyclovir resistance in a child with AIDS. JAMA 1988; 260:2879-82.
16. Jacobson M, Berger T, Fikrig S, et al. Acyclovir-resistant varicella zoster virus infection after chronic oral acyclovir therapy in patients with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 1990; 112:187-91.
17. LeBoit PE, Limova M, Yen TS, Palefsky JM, White CR Jr, Berger TG. Chronic verrucous varicella-zoster virus infection in patients with the acquired immunodeficiency syndrome (AIDS): histologic and molecular biologic findings. Am J Dermatopathol 1992; 14:1-7.
18. Breton G, Fillet A-M, Katlama C, Bricaire F, Caumes E. Acyclovir-resistant herpes zoster in human immunodeficiency virus-infected patients: results of foscarnet therapy. Clin Infect Dis 1998; 27:1525-7.
19. Ghaffar F, Carrick K, Rogers BR, Margraf LR, Krisher K, Ramilo O. Disseminated infection with varicella-zoster virus vaccine strain presenting as hepatitis in a child with adenosine deaminase deficiency. Pediatr Infect Dis J 2000; 19:764-6.
20. Kramer JM, LaRussa P, Tsai WC, et al. Disseminated vaccine strain varicella as the acquired immunodeficiency syndrome-defining illness in a previously undiagnosed child. Pediatrics 2001; 108:E39.
21. Shiraki K, Yamanishi K, Takahashi M. Susceptibility to acyclovir of Oka-strain varicella vaccine and vaccine-derived viruses isolated from immunocompromised patients. J Infect Dis 1984; 150:306-7.
22. Sawyer MH, Inchauspe G, Biron KK, Waters DJ, Straus SE, Ostrove JM. Molecular analysis of the pyrimidine deoxyribonucleoside kinase gene of wild-type and acyclovir-resistant strains of varicella-zoster virus. J Gen Virol 1988; 69:2585-93.
23. Ida M, Kageyama S, Sato H, et al. Emergence of resistance to acyclovir and penciclovir in and genetic analysis of acyclovir-resistant variants. Antiviral Res 1999; 40:155-66.
24. Argaw T, Cohen JI, Klutch M, et al. Nucleotide sequences that distinguish Oka vaccine from parental Oka and other varicella-zoster virus isolates. J Infect Dis 2000; 181:1153-7.
25. Loparev VN, Argaw T, Krause PR, Takayama M, Schmid DS. Improved identification and differentiation of varicella-zoster virus (VZV) wild-type strains and an attenuated varicella vaccine strain using a VZV open reading frame 62-based PCR. J Clin Microbiol 2000; 38:3156-60.
26. Suzutani T, Saijo M, Nagamine M, Ogasawara M, Azuma M. Rapid phenotypic characterization method for herpes simplex virus and varicella-zoster virus thymidine kinases to screen for acyclovir-resistant viral infection. J Clin Microbiol 2000; 38:1839-44.
27. Breitman TR. The feedback inhibition of thymidine. Biochim Biophys Acta 1963; 67:153-5.
28. Sharrar R, LaRussa P, Galea S. The postmarketing safety profile of varicella vaccine. Vaccine 2000; 19:916-23.
29. LaRussa P, Steinberg SP, Shapiro E, Vazquez M, Gershon AA. Viral strain identification in varicella vaccinees with disseminated rashes. Pediatr Infect Dis J 2000; 19:1037-9.
30. Fillet AM, Dumont B, Caumes E, et al. ACV resistant VZV: phenotypic and genetic characterization. J Med Virol 1998; 55:250-4.
31. Lacey SF, Suzutani T, Powwell KL, Purifoy DJM, Honess RW. Analysis of mutants in the tk genes of drug resistant VZV populations using the PCR. J Gen Virol 1991; 72:623-30.
32. Talarico TL, Phelps WC, Biron KK. Analysis of tk genes from ACV resistant mutants of VZV isolated from 11 patients with AIDS. J Virol 1993; 67:1024-33.
33. Boivin G, Edelman CK, Pedneault L, Talarico CL, Biron KK, Balfour HH Jr. Phenotypic and genotypic characterization of acyclovir-resistant mutants of varicella zoster virus isolated from persons with AIDS. J Infect Dis 1994; 170:68-75.
34. Morfin F, Thouvenot D, Turenne-Tessier M, Lina B, Aymard M, Ooka T. Phenotypic and genetic characterization of tk from clinical strains of VZV resistant to ACV. Antimicrob Agents Chemother 1999; 43:2412-6.
35. Saint-Leger E, Caumes E, Breton G, et al. Clinical and virologic characterization of acyclovir-resistant varicella-zoster viruses isolated from 11 patients with acquired immunodeficiency syndrome. Clin Infect Dis 2001; 33:2061-7.
36. Hata A, Asanuma H, Rinki M, et al. Protection from herpes zoster in hematopoietic cell transplant recipients immunized with inactivated varicella vaccine. N Engl J Med 2002; 347:26-34.