Effect of non-selective γ-aminobutyric acid receptor stimulation on motor function of the lower oesophageal sphincter and gastro-oesophageal reflux in healthy human subjects

Alimentary Pharmacology and Therapeutics

Volumn 18, Issue 7, 2003, Pages 699-704

  Cantu P ^a   Carmagnola, S ^a   Savojardo, D ^a   Allocca, M ^a   Penagini, R ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; VALPROIC ACID;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; ESOPHAGUS MOTILITY; FEMALE; GASTROESOPHAGEAL REFLUX; HEADACHE; HUMAN; HUMAN EXPERIMENT; LOWER ESOPHAGUS SPHINCTER PRESSURE; MALE; MOTOR PERFORMANCE; NORMAL HUMAN; PH MEASUREMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SWALLOWING;

ADULT; AGED; AGED, 80 AND OVER; DEGLUTITION; ESOPHAGOGASTRIC JUNCTION; FEMALE; GABA AGENTS; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL MOTILITY; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MANOMETRY; MIDDLE AGED; MUSCLE RELAXATION; RECEPTORS, GABA; VALPROIC ACID;

EID: 0142027688     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2003.01740.x     Document Type: Article

References (29)

1. Johnson L, DeMeester T. Twenty-four-hour pH monitoring of the distal esophagus. A quantitative measure of gastroesophageal reflux. Am J Gastroenterol 1974; 62: 325-32.
2. Rokkas T, Sladen G. Ambulatory esophageal pH recording in gastroesophageal reflux: relevance to the development of esophagitis. Am J Gastroenterol 1988; 83: 629-32.
3. Mittal R, Holloway R, Penagini R, Blackshaw L, Dent J. Transient lower esophageal sphincter relaxation. Gastroenterology 1995; 109: 601-10.
4. Dent J, Holloway RH, Toouli J, Dodds WJ. Mechanisms of lower oesophageal sphincter incompetence in patients with symptomatic gastroesophageal reflux. Gut 1988; 29: 1020-8.
5. Penagini R, Schoeman M, Tippett M, Holloway R. Motor event underlying gastroesophageal reflux in ambulant patients with reflux oesophagitis. Neurogastroenterol Motil 1996; 8: 131-41.
6. Mittal RK, Holloway RH. Effect of atropine on the frequency of reflux and transient lower esophageal sphincter relaxation in normal subjects. Gastroenterology 1995; 109: 1547-54.
7. Penagini R, Bianchi P. Effect of morphine on gastroesophageal reflux and transient lower esophageal sphincter relaxation. Gastroenterology 1997; 113: 409-14.
8. Boulant J, Mathieu S, D'Amato M, Abergel A, Dapoigny M, Bommelaer G. Cholecystokinin in transient lower oesophageal sphincter relaxation due to gastric distension in humans. Gut 1997; 40: 575-81.
9. Hirsch DP, Holloway RH, Tytgat GNJ, Boeckxstaens GEE. Involvement of nitric oxide in human transient lower esophageal sphincter relaxations and esophageal primary peristalsis. Gastroenterology 1998; 115: 1374-80.
10. Lidums I, Lehmann A, Checklin H, Dent J, Holloway R. Control of transient lower esophageal sphincter relaxations and reflux by the GABA agonist Baclofen in normal subjects. Gastroenterology 2000; 118: 7-13.
11. Mott D, Lewis D. The pharmacology and function of central GABAB receptors. Int Rev Neurobiol 1994; 36: 97-223.
12. Bormann J. The 'ABC' of GABA receptors. Trends Pharmacol Sci 2000; 21: 16-9.
13. Yuan C, Liu D, Attele A. GABAergic effects on nucleus tractus solitarius neurons receiving gastric vagal inputs. J Pharmacol Exp Ther 1998; 286: 736-41.
14. Fletcher E, Clark M, Senior P, Furness J. Gene expression and localization of GABAC receptors in neurons of the rat gastrointestinal tract. Neuroscience 2001; 107: 181-9.
15. Zhang Q, Lehmann A, Rigda R, Dent J, Holloway RH. Control of transient lower oesophageal sphincter relaxations and reflux by the GABA B agonist baclofen in patients with gastro-oesophageal reflux disease. Gut 2002; 50: 19-24.
16. Van Herwaarden M, Samsom M, Rydholm H, Smout A. The effect of baclofen on gastro-oesophageal reflux, lower oesophageal sphincter function and reflux symptoms in patients with reflux disease. Aliment Pharmacol Ther 2002; 16: 1655-62.
17. Cange L, Johnsson H, Rydholm H, et al. Baclofen-mediated gastro-oesophageal acid reflux control in patients with established reflux disease. Aliment Pharmacol Ther 2002; 16: 869-73.
18. Ciccaglione A, Marzio L. Effect of acute and chronic administration of the GABAB agonist baclofen on 24 hour pH metry and symptoms in control subjects and in patients with gastrooesophageal reflux disease. Gut 2003; 52: 464-70.
19. Chapman A, Keane PE, Meldrum BS, Simiand J, Vernieres JC. Mechanism of anticonvulsant action of valproate. Prog Neurobiol 1982; 19: 315-59.
20. Loscher W. Valproate induced changes in GABA metabolism at the subcellular level. Biochem Pharmacol 1981; 30; 1366-8.
21. Colombo P, Mangano M, Blanchi P, Penagini R. Effect of calories and fat on post-prandial gastro-oesophageal reflux. Scand J Gastroenterol 2002; 37: 3-5.
22. Penagini R, Mangano M, Blanchi P. Effect of increasing the fat content but not the energy load of a meal on gastrooesophageal reflux and lower oesophageal motor function. Gut 1998; 42: 330-3.
23. Holloway R, Penagini R, Ireland A. Criteria for objective definition of transient lower esophageal sphincter relaxation. Am J Physiol 1995; 268: G128-33.
24. Bourgeois B, Beaumanoir A, Blajev B, et al. Monotherapy with valproate in primary generalized epilepsies. Epilepsia 1987; 28(Suppl. 2): S8-11.
25. Coulter D, Wu H, Allen R. Valproic acid therapy in childhood epilepsy. J Am Med Assoc 1980; 244: 785-8.
26. Schmidt D. Adverse effects of valproate. Epilepsia 1984; 25(Suppl. 1): S44-9.
27. Delgado M, Riela A, Mills J, Browne R, Roach E. Thrombocytopenia secondary to high valproate levels in children with epilepsy. J Child Neurol 1994; 9: 311-4.
28. Zona C, Avoli M. Effects induced by the antiepileptic drug valproic acid upon the ionic current recorded in rat neocortical neurons in cell culture. Exp Brain Res 1990; 81: 313-7.
29. Van Herwaarden MA, Samsom M, Smout AJPM. Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient LES relaxations. Gastroenterology 2000; 119: 1439-46.