Simultaneous enantioselective separation of azelastine and three of its metabolites for the investigation of the enantiomeric metabolism in rats: I. Liquid chromatography-ionspray tandem mass spectrometry and electrokinetic capillary chromatography

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 793, Issue 2, 2003, Pages 389-404

  Heinemann, Ute ^a   Blaschke, Gottfried ^a   Knebel, Norbert ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Viatris Inc   (Germany)

Author keywords

Azelastine; Demethylazelastine; Enantiomer separation

Indexed keywords

ELECTROPHORESIS; METABOLITES;

ENANTIOSELECTIVE SEPARATIONS;

CHROMATOGRAPHY;

6 HYDROXYAZELASTINE; 7 HYDROXYAZELASTINE; ANTIALLERGIC AGENT; AZELASTINE; AZELASTINE N OXIDE; BETA CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; CARBOXYMETHYL BETA CYCLODEXTRIN; DRUG METABOLITE; NORAZELASTINE; POLYACRYLAMIDE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CAPILLARY CHROMATOGRAPHY; CAPILLARY ELECTROPHORESIS; CHIRALITY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG METABOLISM; DRUG TRANSFORMATION; ENANTIOMER; ENANTIOSELECTIVITY; EXTRACTION; LIQUID CHROMATOGRAPHY; MALE; MATERIAL COATING; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; NONHUMAN; PLASMA; PRIORITY JOURNAL; RACEMIC MIXTURE; RAT; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

EID: 0142027500     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(03)00357-X     Document Type: Article

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