Effects of diazepam on closed-and open-loop optokinetic nystagmus (OKN) in humans

Experimental Brain Research

Volumn 152, Issue 4, 2003, Pages 523-527

  Tian, Jing ^a   Wei, Min ^a,c   Liang, Pei Ji ^a   Sun, Fuchuan ^a,b  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^c WASHINGTON UNIVERSITY   (United States)

Author keywords

Closed loop; Diazepam; OKN gain; Open loop control; Optokinetic nystagmus

Indexed keywords

DIAZEPAM; PLACEBO;

ADULT; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG EFFECT; EYE MOVEMENT; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; OPTOKINETIC NYSTAGMUS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; VELOCITY;

ADULT; DIAZEPAM; DOUBLE-BLIND METHOD; HUMANS; NYSTAGMUS, OPTOKINETIC; PHOTIC STIMULATION;

EID: 0142025341     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00221-003-1645-8     Document Type: Article

References (18)

1. Behrens F, Grüsser O-J, Roggenkämper P (1989) Open-loop and closed-loop optokinetic nystagmus in squirrel monkeys (Saimiri sciureus) and in man. Prog Brain Res 90:183-196
2. Bittencourt PRM, Wade P, Smith AT, Richens A (1983) Benzodiazepines impair smooth pursuit eye movements. Br J Clin Pharmacol 15:259-262
3. Bollen E, Bax J, van Dijk JG, Koning M, Bos JE, Kramer CGS, van der Velde EA (1993) Variability of the main sequence. Invest Ophthalmol Vis Sci 34:3700-3704
4. Collewijn' H (1981) The optokinetic system. In: Zuber BL (eds) Models of oculomotor behavior and control. CRC Press, Florida, pp 112-139
5. Frens MA, Mathoera AL, van der Steen J (2000) On the nature of gain changes of the optokinetic reflex. Prog Brain Res 124:247-255
6. Hopfenbeck JR, Cowley DS, Radant A, Greenblatt DJ, Roy-Byrne PP (1995) Effects of diphenhydramine on human eye movements. Psychopharmacology 118:280-286
7. Ilg UJ (1997) Slow eye movements. Prog Neurobiol 53:293-329
8. Leigh RJ, Zee DS (1999) The neurology of eye movements, 3rd edn. Oxford University Press, New York
9. Matsunaga T, Shiraishi T, Kubo T (1983) Differential effects of diazepam upon vestibulo- and visual-oculomotor responses in the rabbit. Acta Otolaryngol Suppl 393:33-39
10. 3H-diazepam binding. Life Sci 22:985-996
11. Robinson DA (1963) A method of measuring eye movement using a scleral search coil in a magnetic field. IEEE Trans Biomed Electr 10:137-145
12. Rothenberg S, Selkoe D (1981a) Specific oculomotor deficit after diazepam. I. Saccadic eye movements. Psychopharmacology 74:232-236
13. Rothenberg S, Selkoe D (1981b) Specific oculomotor deficit after diazepam. II. Smooth pursuit eye movements. Psychopharmacology 74:237-240
14. Roy-Byrne PP, Cowley DS, Radant A, Hommer D, Greenblatt DJ (1993) Benzodiazepine pharmacodynamics: utility of eye movement measures. Psychopharmacology 110:85-91
15. Salas C, Navarro F, Torres B, Delgado-Garcia JM (1992) Effects of diazepam and D-amphetamine on rhythmic pattern of eye movements in goldfish. Neuroreport 3:131-134
16. 3H) flunitrazepam. Life Sci 22:859-866
17. Tian J, Yang Q, Wei M, Terdiman J, Sun F (2002) Neostigmine-induced alterations in fast phase of optokinetic responses in myasthenic ocular palsies. J Neurol 249:867-874
18. Yang Q, Wei M, Sun F, Tian J, Chen X, Lu C (2000) Open-loop and closed-loop optokinetic nystagmus (OKN) in myasthenia gravis and nonmyasthenia subjects. Exp Neurol 166:166-172