Alpha B-crystallin is not a dominant peripheral T-cell autoantigen in multiple sclerosis amongst Sardinians

European Journal of Neurology

Volumn 10, Issue 5, 2003, Pages 583-586

  Sotgiu, S ^a,c   Pugliatti, M ^a   Contu, S ^a   Sanna, A ^a   Sgaramella, E ^a   VanNoort, J M ^b   Rosati, G ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b TNO   (Netherlands)

^c UNIVERSITY OF SASSARI   (Italy)

Author keywords

Alpha B crystallin; Human leucocyte antigen DR; Multiple sclerosis; Sardinia; T cell lines

Indexed keywords

ALPHA BETA CRYSTALLIN; ALPHA CRYSTALLIN; AUTOANTIGEN; BETA CRYSTALLIN; CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HLA DR ANTIGEN; MYELIN; T CELL AUTOANTIGEN; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG; EPITOPE; HLA ANTIGEN;

ALLELE; ARTICLE; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMYELINATING DISEASE; GENETIC LINKAGE; GENETIC PREDISPOSITION; HAPLOTYPE; HUMAN; HUMAN CELL; ITALY; MULTIPLE SCLEROSIS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; BIOSYNTHESIS; COMPARATIVE STUDY; GENETICS; IMMUNOLOGY; METABOLISM;

ALLELES; ALPHA-CRYSTALLIN B CHAIN; AUTOANTIGENS; CELL LINE; CYTOKINES; EPITOPES, T-LYMPHOCYTE; HLA ANTIGENS; HUMANS; ITALY; MULTIPLE SCLEROSIS;

EID: 0142023988     PISSN: 13515101     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-1331.2003.00652.x     Document Type: Article

References (23)

1. Allegretta M, Nicklas JA, Sriram S, Albertini RJ (1990). T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 247:718-721.
2. Bajramovic JJ, Plomp AC, Goes A et al. (2000). Presentation of alpha B-crystallin to T cells in active multiple sclerosis lesions: an early event following inflammatory demyelination. J Immunol 164:4359-4366
3. Correale J, Gilmore W, McMillan M et al. (1995). Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis. J Immunol 154:2959-2986.
4. Hermans G, Stinissen P, Hauben L, Van den Berg-Loonene E, Raus J, Zhang J (1997). Cytokine profile of myelin basic protein-reactive T cells in multiple sclerosis and healthy individuals. Ann Neurol 42:18-27.
5. Marrosu MG, Murru R, Murru MR et al. (2001). Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia. Hum Mol Genet 10:2907-2916.
6. Martin R, Jaraquemada D, Flerlage M et al. (1990). Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T-cell lines from multiple sclerosis patients and healthy individuals. J Immunol 145:540-548.
7. Pette M, Fujita K, Kitze B et al. (1990). Myelin basic protein-specific T lymphocyte lines from MS patients and healthy individuals. Neurology 40:1770-1776.
8. Poser CM, Paty DW, Scheinberg L et al. (1983). New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227-231.
9. Saez-Torres I, Brieva L, Espejo C, Barrau MA, Montalban X, Martinez-Caceres EM (2002). Specific proliferation toward myelin antigens in patients with multiple sclerosis during a relapse. Autoimmunity 35:45-50.
10. Schmidt S (1999). Candidate autoantigens in multiple sclerosis. Multiple Sclerosis 5:147-160.
11. Schmidt S, Linington C, Zipp F et al. (1997). Multiple sclerosis: comparison of the human T-cell response to S100 beta and myelin basic protein reveals parallels to rat experimental autoimmune panencephalitis. Brain 120:1437-1445.
12. Sotgiu S, Serra C, Marrosu MG et al. (1998). Genetic susceptibility to multiple sclerosis in Sardinians: an immunological study. Acta Neurol Scand 98:314-317.
13. Sotgiu S, Serra C, Marrosu MG, Dolei A, Rosati G (1999). Cytokine production in patients carrying multiple sclerosis-linked HLA-DR alleles. J Neurol 12:1194-1196.
14. Sotgiu S, Pugliatti M, Serra C et al. (2000). Cytokines and multiple sclerosis severity no correlation amongst Sardinians. Ann Neurol 48:816 (letter).
15. Sotgiu S, Pugliatti M, Sanna A et al. (2002). Multiple sclerosis complexity in selected populations: the challenge of Sardinia, insular Italy. Eur J Neurol 9:329-341.
16. van Noort JM, van Sechel AC, Bajramovic JJ et al. (1995). The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis. Nature 375:798-801.
17. van Noort JM, van Sechel AC, van Stipdonk MJ, Bajramovic JJ (1998). The small heat shock protein alpha B-crystallin as key autoantigen in multiple sclerosis. Progress Brain Research 117:435-452.
18. van Noort JM, Bajramovic JJ, Plomp AC, van Stipdonk MJ (2000). Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis. J Neuroimmunol 105:46-57.
19. van Stipdonk MJ, Willems AA, Verbeek R, Boog CJ, van Noort JM (2000). T-and B-cell nonresponsiveness to self-alpha B-crystallin in SJL mice prevents the induction of experimental allergic encephalomyelitis. Cell Immunol 204:128-134.
20. Wekerle H, Kojima K, Lannes-Vieira J, Lassmann H, Linington C (1994). Animal models. Ann Neurol 36:S47-S53.
21. Wucherpfennig KW, Sette A, Southwood S et al. (1994). Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J Exp Med 179:279-290.
22. Zhang J, Medaer R, Hashim GA, Chin Y, Van den Berg-Loonen E, Raus JCM (1992). Myelin basic protein-specific T-lymphocytes in multiple sclerosis: precursor frequency, fine specificity and cytotoxicity. Ann Neurol 32:330-338.
23. Zipp F, Weber F, Huber S et al. (1995). Genetic control of multiple sclerosis. Increased production of lymphotoxin and TNF-alpha by antigen-specific T cell lines from HLA-DR2 positive individuals. Ann Neurol 38:723-730.