Long-term neurobehavioral and histological damage in brain of mice induced by L-cysteine

Pharmacology Biochemistry and Behavior

Volumn 75, Issue 4, 2003, Pages 795-799

  Gazit, Vered ^a   Ben Abraham, Ron ^b   Pick, Chaim G ^c   Ben Shlomo, Izhar ^a   Katz, Yeshayahu ^a,d  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d HAEMEK MEDICAL CENTER   (Israel)

Author keywords

Behavior; Brain damage; Eight arm maze; Neurotoxicity

Indexed keywords

CYSTEINE; DNA NUCLEOTIDYLEXOTRANSFERASE; GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; COGNITIVE DEFECT; CONTROLLED STUDY; CONVULSION; GLUCOSE BLOOD LEVEL; HIPPOCAMPUS; HISTOLOGY; HYPOGLYCEMIA; INJECTION; MAZE TEST; MOUSE; NEUROTOXICITY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; SPATIAL MEMORY; SURVIVAL RATE;

ANIMALIA;

EID: 0142011191     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(03)00147-3     Document Type: Article

References (21)

1. Anonymous Brain damage by neonatal hypoglycemia. [editorial] Lancet. 1:1989;882-883.
2. Auer R.N. Progress review: hypoglycemic brain damage. Stroke. 7:1986;699-708.
3. Auer R.N., Siesjö B.K. Biological differences between ischemia, hypoglycemia, and epilepsy. Ann. Neurol. 24:1988;699-707.
4. Auer R.N., Olsson Y., Siesjo B.K. Hypoglycemic brain injury in the rat. Correlation of density of brain damage with the EEG isoelectric time: a quantitative study. Diabetes. 33:1984;1090-1098.
5. Auer R.N., Wieloch T., Olsson Y., Siesjö B.K. The distribution of hypoglycemic brain damage. Acta Neuropathol. 64:1984;177-191.
6. Boyle P.J., Kempers S.F., O'Connor A.M., Nagy R.J. Brain glucose uptake and unawareness of hypoglycemia in patients with insulin-dependent diabetes mellitus. N. Engl. J. Med. 333:1995;1726-1731.
7. Deacon R.M., Croucher A., Rawlins J.N. Hippocampal cytotoxic lesion effects on species-typical behaviors in mice. Behav. Brain Res. 14(132):2002;203-213.
8. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501.
9. Gazit V., Pick C.G., Katz Y. L-Cysteine neurotoxicity is caused by hypoglycemia. [abstract] Neurosci. Lett. (Suppl. 48):1997;S18.
10. Grasl-Kraupp B., Ruttkay-Nedecky B., Koudelka H., Bukowska K., Bursch W., Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology. 21:1995;1465-1468.
11. Janaky R., Varga V., Hermann A., Saransaari P., Oja S.S. Mechanisms of L-cysteine neurotoxicity. Neurochem. Res. 25:2000;1397-1405.
12. Laviola G., Pick C.G., Yanai J., Alleva E. Eight-arm maze performance, neophobia, and hippocampal cholinergic alterations after prenatal oxazepam in mice. Brain Res. Bull. 29(5):1992;609-616.
13. Lehmann A., Hagberg H., Orwar O., Sandberg M. Cysteine sulphinate and cysteate: mediators of cysteine toxicity in the neonatal rat brain? Eur. J. Neurosci. 5:1993;1398-1412.
14. Lucas A., Morley R., Cole T.G. Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia. BMJ. 297:1988;1304-1308.
15. Olney J.W., Ho O.L. Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine. Nature. 227:1970;609-611.
16. Olney J.W., Ho O.L., Rhee V., Schainker B. Cysteine-induced brain damage in infant and fetal rodents. Brain Res. 45:1972;309-313.
17. Olney J.W., Zorumski C., Price M.T., Labruyere J. L-Cysteine, a bicarbonate-sensitive endogenous excitotoxin. Science. 248:1990;596-599.
18. Olton D.S. Spatial memory. Sci. Am. 236(6):1977;82-84.
19. Olton D.S., Samuelson R.J. Remembrance of place passed: spatial memory in rats. J. Exp. Psychiatry. 2:1976;97-116.
20. Pick C.G., Yanai J. Eight arm maze for mice. Int. J. Neurosci. 21:1983;63-66.
21. Sieber F.E., Traystman R.J. Special issues: glucose and the brain. Crit. Care Med. 20:1992;104-114.