Homologous growth hormone accelerates bone healing - A biomechanical and histological study

Bone

Volumn 33, Issue 4, 2003, Pages 628-637

  Kolbeck, S ^a,e   Bail, H ^a   Schmidmaier, G ^a   Alquiza, M ^a   Raun, K ^b   Kappelgard, A ^b   Flyvbjerg, A ^c   Haas, N ^a   Raschke, M ^d  

^a HUMBOLDT UNIVERSITY   (Germany)

^b NOVO NORDISK A S   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d UNIVERSITY OF MÜNSTER   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Biomechanical testing; Fracture healing; Histomorphometry; Osteotomy model; Recombinant growth hormone

Indexed keywords

PLACEBO; RECOMBINANT GROWTH HORMONE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE MINERALIZATION; BONE STRESS; BONE TISSUE; CALCULATION; CALLUS; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FRACTURE HEALING; HISTOLOGY; IMAGE ANALYSIS; MECHANICAL STRESS; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOTOMY; PLATE FIXATION; QUANTITATIVE ANALYSIS; RIGIDITY; STAINING; SWINE; TIBIA; TISSUE SLICE;

EID: 0141996225     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(03)00232-1     Document Type: Article

References (46)

1. Buchanan C.R., Preece M.A. Hormonal control of bone growth. Bone. 6:1990;53-89.
2. Isaksson O.G.P., Lindhal A., Nilsson A., Isgaard J. Mechanisms of the stimulatory effects of growth hormone on longitudinal bone growth. Endocrinol Rev. 8:1987;426-438.
3. Hyer S.L., Rodin D.A., Tobias J.H., Leiper A., Nussey S.S. Growth hormone deficiency during puberty reduces adult bone mineral density. Arch Dis Child. 67:1992;1472-1474.
4. Goldspink D.F., Goldberg A.L. Influence of pituitary growth hormone on DNA synthesis in rat tissues. Am J Physiol. 228:1975;310-317.
5. Kember N.F. Growth hormone and cartilage cell division in hypophysectomized rats. Cell Tissue Kinet. 4:1971;193-199.
6. Kember N.F., Walker K.V. Control of bone growth in rats. Nature. 229:1971;428-429.
7. Ernst M., Froesch E.R. Growth hormone dependent stimulatory of osteoblast like cells in serum-free cultures via local synthesis of insulin-like growth factor I. Biochem Biophy Res Cumm. 151:1988;142-147.
8. Slootweg MC, van Buul-Offers SC. Direct stimulatory effect of growth hormone on DNA synthesis of fetal chicken osteoblasts in culture. Acta Endocrinol 1998; 118.
9. Herold G.H., Hurvitz A., Tadmor A. The effect of growth hormone on the healing of experimental bone defects. Acta Orthop Scand. 42:1971;377-384.
10. van-Herpen H., Rijnberk A., Mol J.A. Production of antibodies to biosynthetic human growth hormone in the dog. Vet Rec. 134:1994;171.
11. Bak B. Fracture healing and growth hormone a biochemical study in the rat . Dan Med Bull. 40:1993;519-536.
12. Bak B., Jorgensen P.H., Andreassen T.T. Increased mechanical strength of healing rat tibial fractures treated with biosynthetic human growth hormone. Bone. 11:1990;233-239.
13. Bak B., Jorgensen P.H., Andreassen T.T. The stimulating effect of growth hormone on fracture healing is dependent on onset and duration of administration. Clin Orthop. 264:1991;295-301.
14. Koskinen E. The repair of experimental fractures under the action of growth hormone, thyreotropin and cortisone a tissue analytic, roentgenologic and autoradiographic study . Ann Chir Gynaecol Fenn [Suppl]. 90:1959;1-48.
15. Pankratiew P. Zum Problem der biologischen Behandlung der Knochenbrüche. Arch Orthop Chir. 32:1932;424-457.
16. Raschke M.J., Bail H., Windhagen H.J., Kolbeck S.F., Weiler A., Raun K., Kappelgard A., Skiaerbaeck C., Hass N.P. Recombinant growth hormone accelerates bone regenerate consolidation in distraction osteogensis. Bone. 24:1999;81-88.
17. Raschke M.J., Kolbeck S.F., Bail H., Schmidmaier G., Flyvberg A., Lindner T., Dahne M., Roenne I.A., Hass N.P. Homologous growth hormone accelerates healing of segmental bone defects. Bone. 29:2001;368-373.
18. Silberberg M., Silberberg R. Influence of acid extract of cattle pituitary gland on bone repair in young guinea pigs. Proc Soc Exp Biol Med. 33:1935;113-119.
19. Boeminghaus H. Untersuchungen über die Einflussbarkeit des Knochenwachstums und der Knochenregenration. Dtsch. Z Chir. 238:1933;684-704.
20. Carpenter J.E., Hipp J.A., Gerhart T.N., Rudman C.G., Hayes W.C., Trippel S.B. Failure of growth hormone to alter the biomechanics of fracture-healing in a rabbit model. J Bone Joint Surg. 74A:1992;359-367.
21. Harris III J.M., Bean D.A., Banks H.H. Effect of phosphate supplementation, thyrocalcitonin, and growth hormone on strength of fracture healing. Surg Forum. 26:1975;519-521.
22. Northmore Ball M.D., Wood M.R., Meggitt B.F. A biomechanical study of the effects of growth hormone in experimental fracture healing. J Bone Joint Surg. 62B:1980;391-396.
23. Shepanek L. The effect of endocrine substances (ACTH and growth hormone) on experimental fractures. Surg Gynaecol Obstet. 96:1953;200-204.
24. Tylkowski C.M., Wezeman H., Ray R.D. Hormonal effects on the morphology of bone defect healing. Clin Orthop. 115:1976;274-285.
25. Aronson J., Harp J.H. Factors influencing the choice of external fixation for distraction osteogenesis. Instr Course Lect. 39:1990;175-183.
26. Ilizarov G.A., Barabash A.P., Imerlishvili I.A., Larionov A.A., Kochetkov I.S. Morphological characteristics of the formation and reconstruction of bone tissue in the replacement of extensive bone defects. Ortop Travmatol Protez. 1:1984;16-20.
27. Brighton C.T. Principles of fracture healing. Part I. The biology of fracture repair. Murray J.A. The American Academy of Orthoppaedic Surgeonas Instructional Courses Lectures XXXIII. 1984;60-82 CV Mosby, St. Louis, MO.
28. Schenk R.K. Biology of fracture repair. Browner B.D., Jupiter J.B., Levine A.M., et al. Skeletal trauma. 1992;31-75 WB Saunders, Philadelphia, PA.
29. Isaksson O.G., Jansson J.O., Gause I.A. Growth hormone stimulates longitudinal bone growth directly. Science. 216:1982;1237-1239.
30. Daughaday W.H., Hall K., Raben M.S., Salmon W.D. Jr, van den Brande J.L., van Wyk J.J. Somatomedin proposed designation for sulphation factor . Nature. 235:1972;107.
31. Daughaday W.H., Mariz I.K., Blethen S.L. Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol extracted serum . J Clin Endocrinol Metab. 51:1980;781-788.
32. Frystyk J., Dinesen B., Orskov H. Non-competetive time-resolved immunofluorometric assay for determination of human insulin-like growth factor I and II. Growth Regulation. 5:1995;169-175.
33. Heydemann A. Knochenbruchheilung bei Hypophysestörungen. Zentralbl Chir. 47:1934;1113.
34. Cordebar R., Guilleman P. Láction de l'hormone somatothrope sur la consolidation osseuse. Press Med. 64:1956;363-365.
35. Koskinen E.V., Lindholm R.V., Nieminen R.A., Puranen J., Atila U. Human growth hormone in fractures of long bones with delayed fracture healing fractures of tibial diaphysis and other bone injuries . Med Welt. 26:1975;1905-1910.
36. Ashton I.K., Dekel S. Fracture repair in the Snell dwarf mouse. Br J Exp Pathol. 64:1983;479-486.
37. Muhlbach R., Hirthe D. The metabolic effect of human growth hormones and their practical use in orthopedics. Beitr Orthop Traumatol. 14:1967;44-55.
38. Muhlbach R., Tarsoly E., Trzenschik K., Hirthe D. Effect of growth hormone on the metabolism of bones and the healing of fractures. Acta Chir Acad Sci Hung. 13:1972;51-63.
39. Zadek R., Robinson R. The effect of growth hormone on experimental long-bone defects. J Bone Joint Surg. 43A:1961;1261.
40. Wray J., Goldstein J. The effect of the pituatiary gland and growth hormone upon the strength of the healing fracture in the rat. J Bone Joint Surg. 48A:1966;815-816.
41. Connolly J.F., Hayes W.C. The compressive behavior as bone as a two-phase porous structure. J Bone Joint Surg. 59A:1977;954-962.
42. Nishiyama K., Sugimoto T., Kaji H., Kanatani M., Kobayashi T., Chihara K. Stimulatory effect of growth hormone on bone resorption and osteoclast differentiation. Endocrinology. 137:(1):1996;35-41.
43. Mosekilde L., Bak B. The effects of growth hormone on fracture healing in rats a histological description . Bone. 14:1993;19-27.
44. Daughaday W.H. Insulin-like growth factors I and II peptide, messenger ribonucleic acid and genestructures, serum and tissue concentrations . Endocr Rev. 10:1989;68-91.
45. Nilsson A., Isgaard J., Lindahl A., Dahlström A., Skottner A., Isaaksson O.G.P. Regulation by growth hormone of number of chondrocytes containing IGF-I in rat growth plate. Science. 233:1986;571-574.
46. Madon R.J., Panton D.M., Flint D.J. Long-term effect of a sheep antiserum to rat growth hormone in vivo in rats is explained by the rat anti-sheep immunoglobulin response. J Endocrinol. 128:1991;229-237.