Growth Hormone Therapy in GH-deficient Adults: Continuous vs. Alternate-days Treatment

Hormone and Metabolic Research

Volumn 35, Issue 9, 2003, Pages 557-561

  Giavoli, C ^a   Cappiello, V ^a   Porretti, S ^a   Ronchi, C L ^a   Orsi, E ^a   Beck Peccoz, P ^a,b   Arosio, M ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

GH Deficiency; GH Replacement; IGF I; Insulin Resistance

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HUMAN GROWTH HORMONE; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SOMATOMEDIN C; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY COMPOSITION; BODY FAT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFECT; FEMALE; GLUCOSE TOLERANCE; GROWTH HORMONE DEFICIENCY; HOMEOSTASIS; HORMONAL THERAPY; HORMONE BLOOD LEVEL; HUMAN; INSULIN SENSITIVITY; MALE; PRIORITY JOURNAL; SIDE EFFECT; STATISTICAL SIGNIFICANCE; SUBSTITUTION THERAPY; THYROID FUNCTION;

ADULT; BODY COMPOSITION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; GROWTH HORMONE; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LIPIDS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; RECOMBINANT PROTEINS;

EID: 0141991083     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-42659     Document Type: Article

References (33)

1. Bengtsson B-A, Johannsson G, Shalet SM, Simpson H, Sonksen PH. Therapeutic Controversy, Treatment of growth hormone deficiency in adults. J Clin Endocrinol Metab 2000; 85: 933-937
2. Gómez JM, Gómez N, Fiter J, Soler J. Effects of long-term treatment with GH in the bone mineral density of adults with hypopituitarism and GH deficiency and after discontinuation of GH replacement. Horm Metab Res 2000; 32: 66-70
3. Aimaretti G, Fanciulli G, Bellone S, Maccario M, Arvat E, Delitala G, Camanni F, Ghigo E. Enhancement of the peripheral sensitivity to growth hormone in adults with GH deficiency. Eur J Endocrinol 2001; 145: 267-272
4. Ekman B, Lindström T, Nyström F, Olsson AG, Toss G, Arnqvist HJ. A dose titration model for recombinant GH substitution aiming at normal plasma concentrations of IGF-I in hypopituitary adults. Eur J Endocrinol 2002; 147: 49-57
5. Frasier SD. Human Growth Hormone [GH] in growth hormone deficiency. Endocr Rev 1983; 4: 155-170
6. Gunnarsson R, Wilton P. Clinical experience with Genotropin worldwide: an update March 1987. Acta Paediatr Scand 1988; 337: 147-152
7. Smith PJ, Hindmarsh PC, Brook CGD. Contribution of dose and frequency of administration to the therapeutic effect of growth hormone. Arch Dis Child 1988; 63: 491-494
8. Drayer NM. The effect of increasing the frequency of growth hormone administration on lower leg length growth. In: Tanner JM (ed). Auxology 88: Perspectives in the Science of Growth and Developpement. London: Smith-Gordon, 1989: 301-306
9. MacGillivray MH, Baptista J, Johansson A. Outcome of a four year randomised study of daily versus three times weekly somatotropin treatment in prepubertal naïve growth hormone deficient children. J Clin Endocrinol Metab 1996; 81: 806-1809
10. Lucidi P, Laureti S, Santoni S, Lauteri M, Busciantella-Ricci N, Angeletti G, Santeusanio F, de Feo P. Administration of recombinant human growth hormone on alternate days is sufficient to increase whole body protein synthesis and lipolysis in growth hormone deficient adults. Clin Endocrinol 2000; 52: 173-179
11. Chung YS, Lee HC, Hwang S, Paik IK, Lee JH, Huh KB. Growth hormone replacement therapy in adults with growth hormone deficiency; thrice weekly low dose administration. J Kor Med Sci 1994; 9: 169-178
12. Amato G, Mazziotti G, di Somma C, Lalli E, de Felice G, Conte M, Rotondi M, Pietrosante M, Lombardi G, Bellastella A, Carella C, Colao A. Recombinant growth hormone therapy in GH-deficient adults: a long term controlled study on daily versus thrice weekly injections. J Clin Endocrinol Metab 2000; 85: 3720-3725
13. Ghigo E, Aimaretti G, Giannotti L, Bellone J, Arvat E, Camanni F. New approach to the diagnosis of growth hormone deficiency in adults. Eur J Endocrinol 1996; 134: 352-356
14. Segal KR, van Loan M, Fitzgerald PI, Hodgdon JA, van Itallie TB. Lean body mass estimation by bioelectrical impedance analysis: a four-site cross validation study. Am J Clin Nutr 1988; 47: 7-14
15. Pichard C, Kyle UG, Bracco D, Slosman DO, Morabia A, Schutz I. Reference values of fat-free and fat masses by bioelectrical impedance analysis in 3393 healthy subjects. Nutrition 2000; 16: 245-254
16. Friedwald WT, Levy RI, Frederickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge. Clin Chem 1972; 18: 499-502
17. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentration in men. Diabetologia 1985; 28: 412-419
18. Katz A, Nambi SS, Mater K et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000; 85: 2402-2410
19. Khandawala HM, McCutcheon IE, Flyvbjerg A, Friend KE. The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev 2000; 21: 215-244
20. Binnerts A, Swart GR, Wilson JH et al. The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clin Endocrinol 1992; 37: 79-87
21. Cuneo RC, Salomon F, Watts GF, Hesp R, Sonksen PH. Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency. Metabolism 1993; 42: 1519-1523
22. Baum HBA, Biller BMK, Finkelstein JS et al. Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. Ann Intern Med 1996; 125: 883-890
23. Weaver JU, Monson JP, Noonan K, John WG, Edwards A, Evans KA, Cunngham J. The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity and cardiovascular risk factors in hypopituitary adults. J Clin Endocrinol Metab 1995; 80: 153-159
24. Jørgensen JOL, Vahl N, Nyholm B. Substrate metabolism and insulin sensitivity following long-term growth hormone GH replacement therapy in GH-deficient adults. Endocrinol Metab 1996; 3: 281-286
25. Chrisoulidou A, Beshyah SA, Rutherford O, Spinks TJ, Mayet J, Kyd P, Anyaoku V, Ayda A, Ariff B, Murphy M, Thomas E, Robinson S, Foale R, Johnston DG. Effects of 7 years of growth hormone replacement therapy in hypopituitary adults. J Clin Endocrinol Metab 2000; 85: 3762-3769
26. Bonora E, Targher G, Alberiche M et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000; 23: 57-63
27. Ikeda Y, Suehiro T, Nakamura T, Kumon Y, Hashimoto K. Clinical significance of insulin resistance index as assessed by homeostasis model assessment. Endocr J 2001; 48: 81-86
28. Bastard JP, Robert JJ, Jardel C, Buckert E, Grimaldi A, Haqinque I. Is quantitative insulin sensitivity check index a fair insulin sensitivity in humans? Diabetes Metab 2001; 27: 69-70
29. de Fronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237: 214-223
30. Hwu CM, Kwok CF, Lai TY, Shih KC, Lee TS, Hsiao LC, Lee SH, Fang VS, Ho LT. Growth Hormone [GH] replacement reduces total body fat and normalizes insulin sensitivity in GH-deficient adults: a report of one-year clinical experience. J Clin Endocrinol Metab 1997; 82: 3285-3292
31. Svensson J, Fowelin J, Landin K, Bengtsson BA, Johansson JO. Effect of seven years of GH-replacement therapy on insulin sensitivity in GH-deficient adults. J Clin Endocrinol Metab 2002; 87: 2121-2127
32. Quon MJ. Editorial: Limitation of the fasting glucose to insulin ratio as an index of insulin sensitivity. J Clin Endocrinol Metab 2001; 86: 4615-4617
33. Porretti S, Giavoli C, Ronchi C, Lombardi G, Zaccaria M, Valle D, Arosio M, Beck-Peccoz P on behalf of Ely Lilly & Co. B9R-EW-GDED Italian Study Group. Recombinant Human GH replacement therapy and thyroid function in a large group of adult GH-deficient patients: when does L-T4 replacement therapy become mandatory? J Clin Endocrinol Metab 2002; 87: 2042-2045