Severe venous thrombosis in an infant heterozygous for the G20210A mutation in the prothrombin gene [2]

Acta Paediatrica, International Journal of Paediatrics

Volumn 92, Issue 9, 2003, Pages 1111-1113

  Martinez Tallo E ^a,b   Alonso, N ^c   Campo Sampedro, F ^c   Agulla, E ^c   Hernandez Rastrollo, R ^c   Galan E ^c  

^a UCIP Hospital Materno Infantil ^*  (Spain)

^b HOSPITAL INFANTA CRISTINA   (Spain)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; LOW MOLECULAR WEIGHT HEPARIN; PROTHROMBIN; TISSUE PLASMINOGEN ACTIVATOR;

ANAMNESIS; BLOOD CLOT LYSIS; BLOOD CLOTTING TEST; CARDIOVASCULAR RISK; CASE REPORT; CLINICAL EXAMINATION; DISEASE SEVERITY; DRUG EFFECT; ECHOCARDIOGRAPHY; EXCHANGE BLOOD TRANSFUSION; FOLLOW UP; GENE MUTATION; HEART ATRIUM SEPTUM DEFECT; HETEROZYGOSITY; HETEROZYGOTE; HUMAN; INFANT; LABORATORY TEST; LETTER; PHYSICAL EXAMINATION; PRIORITY JOURNAL; TREATMENT OUTCOME; VEIN THROMBOSIS;

EID: 0141991063     PISSN: 08035253     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2003.tb02588.x     Document Type: Letter

References (9)

1. Poort SR, Rosendaal FR, Reistma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703
2. Junker R, Koch HG, Auberger K, Münchow N, Ehrenforth S, Nowak-Göttl U (Childhood Thrombophilia Group). Prothrombin G20210A gene mutation and further prothrombotic risk factors in childhood thrombophilia. Arterioscler Thromb Vasc Biol 1999; 19: 2568-72
3. Schobess R, Junker R, Auberger K, Münchow N, Burdach S, Nowak-Göttl U. Factor V G1691A and prothrombin G20210A in childhood spontaneous venous thrombosis - evidence of an age-dependent thrombotic onset in carriers of factor V G1691A and prothrombin G20210A mutation. Eur J Pediatr 1999; 158 Suppl 3: S105-8
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7. De Stefano V, Martinelli I, Mannuccio PM, Paciaroni K, Rossi E, Chiusolo P, et al. The risk of recurrent deep venous thromboembolism among heterozygous carriers of G20210A prothrombin gene mutation. Br J Haematol 2001; 113: 630-5
8. Tormene D, Simioni P, Prandoni P, Franz F, Zerbianati P, Tognin G, Girolami A. The incidence of venous thromboembolism in thrombophilic children: a prospective cohort study. Blood 2002; 100: 2403-5
9. De Stefano V, Martinelli I, Mannuccio PM, Paciaroni K, Chiusolo P, Casorelli I, et al. The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation. N Engl J Med 1999; 341: 801-6.