Synthesis of some conformationally-constrained glutamate mimics of N-{5-[2-(2-amino-3,4-dihydro-4-oxo-5,6,7,8- tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]thien-2-ylcarbonyl-L-glutamic acid (LY254155)

Heterocycles

Volumn 45, Issue 2, 1997, Pages 241-253

  Taylor, Edward C ^a   Hu, Baihua ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0141963290     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-96-7608     Document Type: Article

References (14)

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3. (a) G. Pizzorno, J. A. Sokoloski, A. R. Cashmore, B. A. Moroson, A. D. Cross, and G. P. Beardsley, Mol. Pharmacol, 1991, 39, 85.
4. (b) G. Pizzorno, O. Russello, A. R. Cashmore, B. A. Moroson, A. D. Cross, M. Coronello, and G. P. Beardsley, Proc. Am. Assoc. Cancer Res., 1990, 31, 339.
5. L. L. Habeck, T. A. Leitner, K. A. Shackelford, L. S. Gossett, R. M. Schultz, S. L. Andis, C. Shih, G. B. Grindey, and L. G. Mendelsohn, Cancer Res., 1994, 54, 1021.
6. For leading references to the use of conformationally-constrained α-amino acids as bioactive agents and for conformational probes of active sites, see (a) J. Gante, Angew. Chem. Int. Ed. Engl., 1994,33, 1699;
7. (b) R. M. J. Liskamp, Recl. Trav. Chim. Pays-Bas, 1994,1, 113;
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11. (f) J. Salaün and M. S. Baird, Current Medicinal Chemistry, 1995,
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13. C. Shih, L. S. Gossett, J. F. Worzalla, S. M. Rinzel, G., B. Grindey, P. M. Harrington, and E. C. Taylor, J. Med. Chem., 1992, 35, 1109.
14. A. P. Kozikowski, W. Tuckmantel, I. J. Reynolds, and J. T. Wroblewski, J. Med. Chem., 1993, 33, 1561.