Monitoring of human cytomegalovirus infections in heart transplant recipients by pp65 antigenemia

Clinical Transplantation

Volumn 17, Issue 5, 2003, Pages 423-427

  Sénéchal, Mario ^a,c   Dorent, Richard ^a   Tezenas du Montcel, Sophie ^b   Fillet, Anne Marie ^a   Ghossoub, Jean Jacques ^a   Dubois, Michelle ^a   Pavie, Alain ^a   Gandjbakhch, Iradj ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b Section of Radiology   (France)

^c Groupe Hospitalier Pitie Salpetriere ^*  (Canada)

Author keywords

CMV infection; Ganciclovir pre emptive therapy; Heart transplantation; pp65 antigenemia

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; GANCICLOVIR; PP65 ANTIGEN; PREDNISONE; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; EARLY DIAGNOSIS; GRAFT VERSUS HOST REACTION; HEART TRANSPLANTATION; HUMAN; IMMUNE DEFICIENCY; INFECTION RISK; LIVING DONOR; MAJOR CLINICAL STUDY; PATIENT MONITORING; PREDICTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SENSITIVITY AND SENSIBILITY; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS; STATISTICAL ANALYSIS;

ANTIGENS, VIRAL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; HEART TRANSPLANTATION; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOSUPPRESSIVE AGENTS; LEUKOCYTES; PHOSPHOPROTEINS; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY; VIRAL MATRIX PROTEINS;

EID: 0141955830     PISSN: 09020063     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0012.2003.00064.x     Document Type: Article

References (14)

1. Rubin RH. Prevention and treatment of cytomegalovirus disease in heart transplant patients. J Heart Lung Transplant 2000: 19: 731.
2. Egan JJ, Barber L, Lomax J et al. Detection of human cytomegalovirus antigeneamia: a rapid diagnostic technique for predicting cytomegalovirus infection/pneumonitis in lung and heart transplant recipients. Thorax 1995: 50: 9.
3. Avery RK. Prevention and treatment of cytomegalovirus infection and disease in heart transplant recipients. Curr Opin Cardiol 1998: 13: 122.
4. Camargo LFA, Uip DE, Simpson AAG et al. Comparison between antigenemia and a quantitative-competitive polymerase chain reaction for the diagnosis of cytomegalovirus infection after heart transplantation. Transplant 2001: 71: 412.
5. Bein G, Bitsch A, Hoyer J et al. A longitudinal prospective study of cytomegalovirus pp65 antigenemia in renal transplant recipients. Transplant Int 1993: 6: 185.
6. Lo CY, Ho KN, Yuen KY et al. Diagnosing cytomegalovirus disease in CMV seropositive renal allograft recipients: a comparison between the detection of CMV DNAemia by polymerase chain reaction and antigenemia by CMV pp65 assay. Clin Transplant 1997: 11: 286.
7. Grossi P, Minoli L, Percivalle E, Irish W, Vigano M, Gerna G. Clinical and virological monitoring of human cytomegalovirus infection in 294 heart transplant recipients. Transplant 1995: 59: 847.
8. Vecchio TJ. Predicted value of a single diagnostic test in unselected populations. N Eng J Med 1966: 274: 1171.
9. Limaye AP, Corey L, Koelle DM, Davis CL, Boeckh M. Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants. Lancet 2000: 356: 645.
10. Egan JJ, Lomax J, Barber L et al. Preemptive treatment for the prevention of cytomegalovirus disease in lung and heart transplant recipients. Transplant 1998: 65: 747.
11. Merigan TC, Renlund DG, Keay S et al. A controlled trial of ganciclovir to prevent cytomegalovirus disease after heart transplantation. N Engl J Med 1992: 326: 1182.
12. Macdonald PS, Keogh AM, Marshman D et al. A double-blind placebo-controlled trial of low-dose ganciclovir to prevent cytomegalovirus disease after heart transplantation. Transplant 1995: 14: 32.
13. Gerna G, Zipeto K, Parea M et al. Monitoring of human cytomegalovirus infections and ganciclovir treatment in heart transplant recipients by determination of viremia, antigenemia, and DNAemia. J Infect Dis 1991: 164: 488.
14. Koskinen P, Nieminen M, Mattila S, Lautenschlager I. Quantitative immuno detection of cytomegalovirus antigenemia in the clinical diagnosis of CMV infection after heart transplantation. Transplant Proc 1993: 25: 1426.