Leptin, soluble leptin receptor, and transforming growth factor-β1 levels in minimal change nephrotic syndrome

Pediatric Nephrology

Volumn 18, Issue 10, 2003, Pages 1009-1014

  Buyan, Necla ^a,b   Özkaya, Ozan ^a   Bideci, Aysun ^a   Söylemezoǧlu, Oǧuz ^a   Cinaz, Peyami ^a   Gönen, Sevim ^a   Kalman, Süleyman ^a   Bakkaloǧlu, Sevcan ^a   Hasanoǧlu, Enver ^a  

^a GAZI UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

Leptin; Minimal change nephrotic syndrome; Soluble leptin receptor; Transforming growth factor 1

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CHILD; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; HUMAN; MALE; NEPHROTIC SYNDROME; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PROTEIN INTERACTION; PROTEIN URINE LEVEL; PROTEINURIA; REMISSION; STATISTICAL ANALYSIS;

BODY MASS INDEX; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; LEPTIN; MALE; NEPHROSIS, LIPOID; PROTEINURIA; RECEPTORS, CELL SURFACE; SOLUBILITY; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0141955262     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-003-1221-2     Document Type: Article

References (18)

1. Stenvinkel P, Lönnqvist F, Schalling M (1999) Molecular studies of leptin: implications for renal disease. Nephrol Dial Transplant 14:1103-1112
2. Wolf G, Chen S, Han DC, Ziyadeh FN (2002) Leptin and renal disease. Am J Kidney Dis 39:1-11
3. Lahlou N, Issad T, Lebouc Y, Carel JC, Camoin L, Roger M, Girard J (2000) Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass. Diabetes 49:1347-1352
4. Lahlou N, Clement K, Carel JC, Vaisse C, Lotton C, Le Bihan Y, Bosdevant A, Lebouc Y, Fraguel P, Roger M, Guy-Grand B (2002) Mutations in the human leptin and leptin receptor genes as models of serum leptin receptor regulation. Diabetes 51:2105-2112
5. Wolf G, Hamann A, Han DC, Helmchen U, Thaiss F, Ziyadeh FN, Stahl RAK (1999) Leptin stimulates proliferation and TGFβ expression in renal glomerular endothelial cells: potential role in glomerulosclerosis. Kidney Int 56:860-872
6. Ballerman B (1999) A role for leptin in glomerulosclerosis? Kidney Int 56:1154-1155
7. International Study of Kidney Disease in Children (1978) The nephrotic syndrome in children: prediction of histopathology from clinical and laboratory characteristics at the time of diagnosis. Kidney Int 13:159-165
8. Liu C, Liu X, Barry G, Ling N, Maki RA, Souza EBD (1997) Expression and characterization of a putative high affinity human soluble leptin receptor. Endocrinology 138:3548-3554
9. Schroth M, Gröschl M, Dörr HG, Blum WF, Rascher W, Dötsch J (2001) Renal loss of leptin in patients with nephrotic syndrome. Eur J Endocrinol 145:463-468
10. Özata M, Oktenli Ç, Özgürtaş T, Bulucu F, Çaǧlar K, Bingöş, Vural A, Özdemir I Çaǧlayan (2002) Increased fasting plasma acylation-stimulating protein concentrations in nephrotic syndrome. J Clin Endocrinol Metab 87:853-859
11. Tan JT, Patel BK, Kaplan LM, Koenig JL, Hooi SC (1998) Regulation of leptin expression and secretion by corticosteroids and insulin. Implications for body weight. Endocrine 8:85-92
12. Lewandowski K, Randeva HS, O'Callaghan CJ, Horn R, Medley GF, Hillhouse EW, Brabant G, O'Hare P (2001) Effects of insulin and glucocorticoids on the leptin system are mediated through free leptin. Clin Endocrinol (Oxf) 54:533-539
13. Taylor GM, Neuhaus TJ, Shah V, Dillon S, Barrat TM (1997) Charge and size selectivity of proteinuria in children with idiopathic nephrotic syndrome. Pediatr Nephrol 11:404-410
14. Tryggvason K, Wartiovaara J (2001) Molecular basis of glomerular permselectivity. Curr Opin Nephrol Hypertens 10:543-549
15. Lammert A, Kiess W, Bottner A, Glasow A, Kratzsch J (2001) Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun 18:982-988
16. Monteleone P, Fabrazzo M, Tortorella A, Fuschino A, Maj M (2002) Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum. Mol Psychiatry 7:17
17. Stejskal D, Bartek J, Ruzicka V, Stejskal P, Jedelsky L, Oral I, Horalik D, Zurek M (1999) Determination of leptin receptor in the serum and relations to laboratory and anthropological parameters in patients with atherosclerotic complications. Acta Univ Palacki Olomuc Fac Med 142:89-92
18. Chan JL, Bluher S, Yiannakouris N, Suchard MA, Kratzsch J, Mantzoros CS (2002) Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes 51:2105-2112