GT3 synthesis in the proximal Golgi occurs in a compartment different from those for GD3 and GM3 synthesis

Journal of Neurochemistry

Volumn 67, Issue 4, 1996, Pages 1393-1400

  Rosales Fritz, Víctor M ^a   Maxzúd, Mariana K ^a   Maccioni, Hugo J F ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

Cis medial Golgi; Ganglioside; GD3 synthesis; GM3 synthesis; GT3 synthesis; Proximal Golgi; Trans Golgi

Indexed keywords

GANGLIOSIDE GD3; GANGLIOSIDE GM3; GANGLIOSIDE GT 1B;

ANIMAL CELL; ARTICLE; CELL METABOLISM; CELLULAR DISTRIBUTION; CHICK EMBRYO; GOLGI COMPLEX; NONHUMAN; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; RETINA CELL;

ANIMALIA; TRIXIS;

EID: 0141954528     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67041393.x     Document Type: Article

References (34)

1. Arce A., Maccioni H. J. F., and Caputto R. (1966) Enzymatic binding of sialyl group to ganglioside derivatives by preparations from the brain of young rat. Arch. Biochem. Biophys. 116, 52-58.
2. Donaldson J. G. and Klausner R. D. (1994) ARF: a key regulatory switch in membrane traffic and organelle structure. Curr. Opin. Cell Biol. 6, 527-532.
3. Freischütz B., Saito M., Rahmann H., and Yu R. K. (1994) Activities of five different sialyltransferases in fish and rat brain. J. Neurochem. 62, 1965-1973.
4. Hakomori S. H. (1984) Glycosphingolipids as differentiation-dependent, tumor associated markers and as regulators of cell proliferation. Trends Biochem. Sci. 9, 453-456.
5. Hamburger V. and Hamilton H. L. (1951) A series of normal stages in the development of the chick embryo. J. Morphol. 88, 49-92.
6. Iber H., van Echten G., and Sandhoff K. (1992a) Fractionation of primary cultured cerebellar neurons: distribution of sialyltransferases involved in ganglioside biosynthesis. J. Neurochem. 58, 1533-1537.
7. Iber H., Zacharias C., and Sandhoff K. (1992b) The "c" series gangliosides GT3, GT2 and GP1c are formed in rat liver Golgi by the same set of glycosyltransferases that catalyse the biosynthesis of asialo-, "a" and "b" series gangliosides. Glycobiology 2, 137-142.
8. Keenan T. W., Morre D. J., and Basu S. (1974) Ganglioside biosynthesis. Concentration of glycosphingolipid glycosyltransferases in Golgi apparatus from rat liver. J. Biol. Chem. 249, 310-315.
9. Klausner R. D., Donaldson J. G., and Lippincott-Schwartz J. (1992) Brefeldin A: insights into the control of membrane traffic and organelle structure. J. Cell Biol. 116, 1071-1080.
10. Maccioni H. J. F., Arce A., Landa C. A., and Caputto R. (1974) Rat brain microsomal gangliosides. Accessibility to a neuraminidase preparation and the possible existence of different pools in relation to their biosynthesis. Biochem. J. 138, 291-298.
11. Maccioni H. J. F., Panzetta P., and Landa C. A. (1988) Biosynthesis and expression of gangliosides during neural differentiation, in New Trends in Ganglioside Research: Neurochemical and Neuroregenerative Aspects (Ledeen R. W., Hogan E. L., Tettamanti G., Yates A. J., and Yu R. K., eds), pp. 295-305. Liviana Press, Padova, Italy.
12. Martina J. A., Daniotti J. L., and Maccioni H. J. F. (1995) A UDP-sugar pyrophosphatase is developmentally regulated in the rat retina. J. Neurochem. 64, 1274-1280.
13. Maxzúd M. K., Daniotti J. L., and Maccioni H. J. F. (1995) Functional coupling of glycosyl transfer steps for synthesis of gangliosides in Golgi membranes from neural retina cells. J. Biol. Chem. 270, 20207-20214.
14. Miller-Prodraza H. and Fishman P. H. (1984) Effect of drugs and temperature on biosynthesis and transport of glycosphingolipids in cultured neurotumor cells. Biochim. Biophys. Acta 804, 44-51.
15. Mollenhauer H. H., Morré D. J., and Rowe L. D. (1990) Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochim. Biophys. Acta 1031, 225-246.
16. Nakayama J., Fukuda M. N., Hirabayashi Y., Kanamori A., Sasaki K., Nishi T., and Fukuda M. (1996) Expression cloning of a human GT3 synthase. GD3 and GT3 are synthesized by a single enzyme. J. Biol. Chem. 271, 3684-3691.
17. Nores G. A. and Caputto R. (1986) Regulation of ganglioside and sialoglycoprotein biosynthesis. Effect of drugs affecting membrane flow. Neurochem. Int. 8, 501-506.
18. Nores G. A., Mizutamari R., and Kremer M. (1994) Chromatographic tank designed to obtain highly reproducible HPTLC-chromatograms of gangliosides and neutral glycosphingolipids. J. Chromatogr. 686, 155-157.
19. Panzetta P., Gravotta D., and Maccioni H. J. F. (1987) Biosynthesis and expression of gangliosides during differentiation of chick embryo retina cells in vitro. J Neurochem. 49, 1763-1771.
20. Pressman B. C. (1976) Biological applications of ionophores. Annu. Rev. Biochem. 45, 501-530.
21. Rosales Fritz V. M. and Maccioni H. J. F. (1995) Effects of brefeldin A on synthesis and intracellular transport of ganglioside GT3 by chick embryo retina cells. J. Neurochem. 65, 1859-1864.
22. Roseman S. (1970) The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intracellular adhesion. Chem. Phys. Lipids 5, 270-297.
23. Rösner H. (1994) Gangliosides and brain development, in Glycobiology and the Brain (Nicolini M. and Zatta P. F., eds), pp. 19-36. Pergamon Press, New York.
24. Rösner H., Greis C., Willibald C. J., and Henke-Fahle S. (1988) Developmental expression of gangliosides in nervous tissue. A polysialoganglioside antigen in chicken and rat nervous tissue reacting with the monoclonal antibody Q211, in New Trends in Ganglioside Research (Ledeen R., Tettamanti G., Yu R. K., Hogan E., and Yates A., eds), pp. 435-448. Springer, New York.
25. Rothman J. E. (1994) Mechanisms of intracellular protein transport. Nature 372, 55-63.
26. Sjoberg E. R. and Varki A. (1993) Kinetic and spatial interrelationships between ganglioside glycosyltransferases and O-acetyl-transferase(s) in human melanoma cells. J. Biol. Chem. 268, 10185-10196.
27. Svennerholm L. (1963) Chromatographic separation of human brain gangliosides. J. Neurochem. 10, 613-623.
28. Tartakoff A. M. (1983) Perturbation of vesicular traffic with the carboxylic ionophore monensin. Cell 32, 1026-1028.
29. Trinchera M., Pirovano B., and Ghidoni R. (1990) Sub-Golgi distribution in rat liver of CMP-NeuAc GM3 and CMP-NeuAc GT1b α 2→8 sialyltransferases and comparison with the distribution of the other glycosyltransferase activities involved in ganglioside biosynthesis. J. Biol. Chem. 265, 18242-18247.
30. van Echten G. and Sandhoff K. (1989) Modulation of ganglioside biosynthesis in primary cultured neurons. J. Neurochem. 52, 207-214.
31. van Echten G. and Sandhoff K. (1993) Ganglioside metabolism. Enzymology, topology and regulation. J. Biol. Chem. 268, 5341-5344.
32. van Echten G., Iber H., Stolz H., Takatsuki A., and Sandhoff K. (1990) Uncoupling of ganglioside biosynthesis by brefeldin A. Eur. J. Cell Biol. 51, 135-139.
33. Young W. W. Jr., Lutz M. S., Mills S. E., and Leschler-Osborn S. (1990) Use of brefeldin A to define sites of glycosphingolipid synthesis: GA2/GM2/GD2 synthase is trans to the brefeldin A block, Proc. Natl. Acad. Sci. USA 87, 6838-6842.
34. Yu R. K. and Ando S. (1980) Structures of some new complex gangliosides of fish brain, in Structure and Function of Gangliosides (Svennerholm L., Dreyfus H., and Urban P. F., eds), pp. 33-45. Plenum, New York.