Suppression of fibroblast activity by an inhibitor of dipeptidyl peptidase IV: A possible therapeutic strategy for rheumatoid arthritis [14]

Clinical and Experimental Rheumatology

Volumn 21, Issue 5, 2003, Pages 685-

  Williams, Y N ^b   Sugita, T ^a   Nosaka, Y ^b   Kubota, Tetsuo ^b  

^a Discovery Research Laboratory   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2' [2'' AMINO 3'' (INDOL 3''' YL) 1'' OXOPROPYL] 1',2',3',4' TETRAHYDRO 6',8' DIHYDROXY 7' METHOXYISOQUINOL 3 YL CARBONYLAMINO] 4 HYDROXYMETHYL 5 HYDROXYPENTANOIC ACID; DIPEPTIDYL PEPTIDASE IV; ENZYME INHIBITOR; PLATELET DERIVED GROWTH FACTOR; TMC 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CELL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; FIBROBLAST; IMMUNE RESPONSE; LETTER; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; RHEUMATOID ARTHRITIS;

ANIMALS; ANTIGENS, CD26; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; FIBROBLASTS; MICE;

EID: 0141953127     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (9)

1. KUBOTA T, FLENTKE GR, BACHOVCHIN WW, STOLLAR BD: Involvement of dipeptidyl peptidase IV in an in vivo immune response. Clin Exp Immunol 1992; 89: 192-7.
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3. TANAKA S, MURAKAMI T, NONAKA N, OHNUKI T, YAMADA M, SUGITA T: Anti-arthritic effects of the novel dipeptidyl peptidase IV inhibitors TMC-2A and TSL-225. Immunopharmacology 1998; 40: 21-6.
4. WILLIAMS YN, BABA H, HAYASHI S et al.: Dipeptidyl peptidase IV on activated T cells as a target molecule for therapy of rheumatoid arthritis. Clin Exp Immunol 2003; 131: 68-74.
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