Maternal-fetal distribution and prenatal toxicity of 2,2,4-trimethyl-1,2-dihydroquinoline in the rat

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 68, Issue 4, 2003, Pages 375-382

  Sitarek, Krystyna ^a   Sapota, Andrzej ^a  

^a NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; DIHYDROQUINOLINE DERIVATIVE; MONOMER;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FEMALE; FETUS; KINETICS; MOTHER; NONHUMAN; ORGANOGENESIS; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; TERATOGENICITY; TISSUE DISTRIBUTION; TOXICITY;

ABNORMALITIES, DRUG-INDUCED; ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; BODY WEIGHT; CARBON RADIOISOTOPES; EMBRYONIC AND FETAL DEVELOPMENT; EMBRYONIC DEVELOPMENT; FEMALE; KIDNEY; MATERNAL-FETAL EXCHANGE; ORGAN SIZE; PLACENTA; PREGNANCY; PREGNANCY, ANIMAL; PRENATAL EXPOSURE DELAYED EFFECTS; QUINOLINES; RATS; TISSUE DISTRIBUTION;

EQUIDAE;

EID: 0141924690     PISSN: 15429733     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdrb.10031     Document Type: Article

References (18)

1. Brij M, Mitrinka H, Rawnsley M. 1977. Clinical, biochemical and hematological reference values in normal experimental animals. New York: Masson Publishing.
2. Dawson AB. 1926. A note on the staining of the skeleton of cleared specimens with alizarin red-S. Stain Technol 1:123-124.
3. Fisher LD, van Belle G. 1993. Biostatistics. A methodology for the health sciences. New York: John Wiley and Sons.
4. Górny R, Jȩdrychowski R, Stetkiewicz J, Taszakowski T, Baranczewski P, Swiercz R, Stetkiewicz I, Lao I, Czerski B. 1991. Assessment of acute and subacute toxicity of Polnoks R sulfonamide TS and N-methylmorfoline [in Polish]. Report IMP 1.18. Lodz: Nofer Institute of Occupational Medicine.
5. Ioannou YM, Burka LT, Sanders JM, Moorman MP, Matthews HB. 1987. Absorption, distribution, metabolism and excretion of 1,2-dihydro-2,2,4-trimethylquinoline in the male F344 rat. Drug Metab Dispos 15:367-373.
6. Kelman G. Ya. 1966. A study of toxicity of certain rubber antioxidants and their hygienic assessment [in Russian]. Hyg Sanit 2:25-28.
7. Krzymowski T 1973. Physiology of animals [in Polish]. Warsaw: PWRiL.
8. Mahin DT, Lofberg TR. 1966. A simplified method of sample preparation for determination of tritium carbon-14, or sulfur-35 in blood or tissue by liquid scintillation counting. Anal Biochem 16:500-509.
9. National Toxicology Program. 1997. Toxicology and carcinogenesis studies of 1,2-dihydro-2,2,4-trimethylquinoline (CAS No. 147-47-7) in F344/N rats and B6C3F1 mice (dermal studies) and the dermal initiation/promotion study in female Sencar mice. NIH Technical Report No. 456.
10. Nau H. 1991. Pharmacokinetic consideration in the design and interpretation of developmental toxicity studies. Fundam Appl Toxicol 16:219-221.
11. Official Journal. 1997. No. 111 [in Polish], 3445-3453.
12. Panner BJ, Packer JT. 1961. Hepatic alterations in rats fed 1,2-dihydro-2,2,4-trimethyl-quinoline, Flectol H. Proc Soc Exp Biol Med 106: 16-19.
13. Palmer AK. 1977. Incidence of sporadic malformations, anomalies and variations in random bred laboratory animals. In: Neubert D, Merker HJ, Kwasigroch TE, editors. Methods in prenatal toxicology. Stuttgart: Georg Thieme Publishers. pp. 52-71.
14. Sitarek K, Berlifiska B, Barafiski B. 1996. Evaluation of oral exposure to Polnoks R for female rats in developmental toxicity studies. Teratog Carcinog Mutagen 16:75-80.
15. Tuchmann-Duplessis H. 1977. Selection of animal species for teratological drug testing. In: Neubert D, Merker HJ, Kwasigroch TE, editors. Methods in prenatal toxicology. Stuttgart: Georg Thieme Publishers. pp. 25-34.
16. Wilson JG. 1965. Embryological considerations in teratology. In: Wilson JG, Warkany J, editors. Teratology: principles and techniques. Chicago: University of Chicago Press. pp. 251-277.
17. Working PK, Mattison DR. 1993. Reproductive and developmental toxicity testing methods in animals. In: Paul M, editor. Occupational and environmental reproductive hazards. A guide for clinicians. London: Williams and Wilkins. pp. 91-99.
18. Zar JH. 1974. Biostatistical analysis. New York: Englewood Cliffs, Prentice-Hall.