Effect of IC14, an anti-CD14 antibody, on plasma and cell-associated chemokines during human endotoxemia

European Cytokine Network

Volumn 14, Issue 3, 2003, Pages 158-162

  Olszyna, Dariusz P ^a   Verbon, Annelies ^a   Pribble, John P ^b   Turner, Terence ^b   Axtelle, Tim ^b   Van Deventer, Sander J H ^a   Van Der Poll, Tom ^a,c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ELI LILLY AND COMPANY   (United States)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Erythrocytes; Interleukin 8; Lipopolysaccharide; Monocyte chemoattractant protein 1

Indexed keywords

CD14 ANTIGEN; CYTOKINE; IC 14; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL FRACTIONATION; CELL LYSATE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTOXEMIA; ERYTHROCYTE; HUMAN; INJECTION; MALE; MONONUCLEAR CELL; POLYMORPHONUCLEAR CELL; PROTEIN BLOOD LEVEL; PROTEIN PROTEIN INTERACTION; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTIGENS; ANTIGENS, CD14; CHEMOKINES; DOUBLE-BLIND METHOD; ENDOTOXEMIA; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LIPOPOLYSACCHARIDES; MALE; PLACEBOS; REFERENCE VALUES;

EID: 0141922968     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Adams DH, Lloyd AR. 1997. Chemokines: leucocyte recruitment and activation cytokines. Lancet 349: 490.
2. Luster AD 1998. Chemokines-chemotactic cytokines that mediate inflammation. (Review) N. Engl. J. Med. 338: 436.
3. Miller LH, Mason SJ, Dvorak JA, McGinniss MH, Rothman IK. 1975. Erythrocyte receptors for (Plasmodium knowlesi) malaria: Duffy blood group determinants. Science 189: 561.
4. Darbonne WC, Rice GC, Mohler MA, Apple T, Hebert CA, Valente AJ, Baker JB. 1991. Red blood cells are a sink for interleukin 8, a leukocyte chemotaxin. J. Clin. Invest. 88: 1362.
5. Marie C, Fitting C, Cheval C, Losser MR, Carlet J, Payen D, Foster K, Cavaillon JM. 1997. Presence of high levels of leukocyte-associated interleukin-8 upon cell activation and in patients with sepsis syndrome. Infect. Immun. 65: 865.
6. Tilg H, Shapiro L, Atkins MB, Dinarello CA, Mier JW. 1993. Induction of circulating and erythrocyte-bound IL-8 by IL-2 immunotherapy and suppression of its in vitro production by IL-1 receptor antagonist and soluble tumor necrosis factor receptor (p75) chimera. J. Immunol. 151: 3299.
7. Tilg H, Pape D, Trehu E, Shapiro L, Atkins MB, Dinarello CA, Mier JW. 1993. A method for the detection of erythrocyte-bound interleukin-8 in humans during interleukin-1 immunotherapy. J. Immunol. Methods 163: 253.
8. Marie C, Muret J, Fitting C, Losser MR, Payen D, Cavaillon JM. 1998. Reduced ex vivo interleukin-8 production by neutrophils in septic and nonseptic systemic inflammatory response syndrome. Blood 91: 3439.
9. Olszyna DP, De Jonge E, Dekkers PE, van Deventer SJ, van der Poll T. 2001. Induction of cell-associated chemokines after endotoxin administration to healthy humans. Infect. Immun. 69: 2736.
10. Aderem A, Ulevitch RJ. 2000. Toll-like receptors in the induction of the innate immune response. (Review) Nature 406: 782.
11. Verbon A, Dekkers PE, ten Hove T, Hack CE, Pribble JP, Turner T, Souza S, Axtelle T, Hoek FJ, van Deventer SJ, van der Poll T. 2001. IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans. J. Immunol. 166: 3599.
12. Pugin J, Heumann ID, Tomasz A, Kravchenko VV, Akamatsu Y, Nishijima M, Glauser MP, Tobias PS, Ulevitch RJ. 1994. CD14 is a pattern recognition receptor. Immunity 1: 509.
13. Haziot A, Ferrero E, Kontgen F, Hijiya N, Yamamoto S, Silver J, Stewart CL, Goyert SM. 1996. Resistance to endotoxin shock and reduced dissemination of gram- negative bacteria in CD14-deficient mice. Immunity 4: 407.
14. Schimke J, Mathison J, Morgiewicz J, Ulevitch RJ. 1998. Anti-CD14 mAb treatment provides therapeutic benefit after in vivo exposure to endotoxin. Proc. Natl. Acad. Sci. USA 95: 13875.
15. Leturcq DJ, Moriarty AM, Talbott G, Winn RK, Martin TR, Ulevitch RJ. 1996. Antibodies against CD14 protect primates from endotoxin-induced shock. J. Clin. Invest. 98: 1533.
16. Haziot A, Lin XY, Zhang F, Goyert SM. 1998. The induction of acute phase proteins by lipopolysaccharide uses a novel pathway that is CD14-independent. J. Immunol. 160: 2570.
17. Friedland JS, Suputtamongkol Y, Remick DG, Chaowagul W, Strieter RM, Kunkel SL, White NJ, Griffin GE. 1992. Prolonged elevation of interleukin-8 and interleukin-6 concentrations in plasma and of leukocyte interleukin-8 mRNA levels during septicemic and localized Pseudomonas pseudomallei infection. Infect. Immun. 60: 2402.