DNA gyrase and topoisomerase IV mutations in clinical isolates of Ureaplasma spp. and Mycoplasma hominis resistant to fluoroquinolones

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 10, 2003, Pages 3323-3325

  Bebear C M ^a   Renaudin, H ^a   Charron, A ^a   Clerc, M ^a   Pereyre, S ^a   Bebear C ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE;

ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL MUTATION; BACTERIUM ISOLATE; DRUG EFFECT; ENZYMOLOGY; ESCHERICHIA COLI; FEMALE; GENETICS; GYRA GENE; HUMAN; MALE; MICROBIOLOGICAL EXAMINATION; MINIMUM INHIBITORY CONCENTRATION; MUTATION; MYCOPLASMA HOMINIS; NONHUMAN; PARC GENE; PRIORITY JOURNAL; UREAPLASMA; UREAPLASMA UREALYTICUM;

EID: 0141890247     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.10.3323-3325.2003     Document Type: Article

References (14)

1. Abele-Horn, M., C. Wolff, P. Dressel, F. Pfaff, and A. Zimmermann. 1997. Association of Ureaplasma urealyticum biovars with clinical outcome for neonates, obstetric patients, and gynecological patients with pelvic inflammatory disease. J. Clin. Microbiol. 35:1199-1202.
2. Abraham, B., C. Leclercq, C. Bébéar, H. Renaudin, and F. Janbon. 2001. Septic arthritis due to Ureaplasma urealyticum: concerning one case. Med. Mal. Infect. 31:453-454.
3. Bast, D. J., D. E. Low, C. L. Duncan, L. Kilburn, L. A. Mandell, R. J. Davidson, and J. C. S. Deazavedo. 2000. Fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae: contributions of type II topoisomerase mutations and efflux to levels of resistance. Antimicrob. Agents Chemother. 44:3049-3054.
4. Bébéar, C. M., H. Renaudin, A. Charron, J. M. Bové, C. Bébéar, and J. Renaudin. 1998. Alterations in topoisomerase IV and DNA gyrase in quinolone-resistant mutants of Mycoplasma hominis obtained in vitro. Antimicrob. Agents Chemother. 42:2304-2311.
5. Bébéar, C. M., H. Renaudin, A. Charron, D. Gruson, M. Lefranqois, and C. Bébéar. 2000. In vitro activity of trovafloxacin compared to those of five antimicrobials against Mycoplasma hominis and Ureaplasma urealyticum fluoroquinolone-resistant isolates that have been genetically characterized. Antimicrob. Agents Chemother. 44:2557-2560.
6. Bébéar, C. M., J. Renaudin, A. Charron, H. Renaudin, B. de Barbeyrac, T. Schaeverbeke, and C. Bébéar. 1999. Mutations in the gyrA, parC, and pare genes associated with fluoroquinolone resistance in clinical isolates of Mycoplasma hominis. Antimicrob. Agents Chemother. 43:954-956.
7. Blanchard, A., and C. M. Bébéar. 2002. Mycoplasmas of humans, p. 45-71. In S. Razin and R. Herrmann (ed.), Molecular biology and pathogenicity of mycoplasmas. Kluwer Academic/Plenum Publishers, London, United Kingdom.
8. Hooper, D. C. 1998. Bacterial topoisomerases, anti-topoisomerases, and antitopoisomerase resistance. Clin. Infect. Dis. 27:S54-S63.
9. Ince, D., and D. C. Hooper. 2000. Mechanisms and frequency of resistance to premafloxacin in Staphylococcus aureus: novel mutations suggest novel drug-target interactions. Antimicrob. Agents Chemother. 44:3344-3350.
10. Kong, F. R., Z. F. Ma, G. James, S. Gordon, and G. L. Gilbert. 2000. Species identification and subtyping of Ureaplasma parvum and Ureaplasma urealyticum using PCR-based assays. J. Clin. Microbiol. 38:1175-1179.
11. Reinhardt, A. K., C. M. Bébéar, M. Kobisch, I. Kempf, and A. V. Gautier-Bouchardon. 2002. Characterization of mutations in DNA gyrase and topoisomerase IV involved in quinolone resistance of Mycoplasma gallisepticum mutants obtained in vitro. Antimicrob. Agents Chemother. 46:590-593.
12. Robertson, J. A., G. W. Stemke, J. W. Davis, R. Harasawa, D. Thirkell, F. R. Kong, M. C. Shepard, and D. K. Ford. 2002. Proposal of Ureaplasmaparvum sp. nov. and emended description of Ureaplasma urealyticum (Shepard et al. 1974) Robertson et al. 2001. Int. J. Syst. Evol. Microbiol. 52(Part 2):587-597.
13. Taba, H., and N. Kusano. 1998. Sparfloxacin resistance in clinical isolates of Streptococcus pneumoniae: involvement of multiple mutations in gyrA and parC genes. Antimicrob. Agents Chemother. 42:2193-2196.
14. Waites, K. B., C. M. Bébéar, J. A. Robertson, D. F. Talkington, and G. E. Kenny (ed.). 2001. Cumitech 34: laboratory diagnosis of mycoplasmal infections. American Society for Microbiology, Washington, D.C.