The process development of a novel aldose reductase inhibitor, FK366. Part 1. Improvement of discovery process and new syntheses of 1-substituted quinazolinediones

Organic Process Research and Development

Volumn 7, Issue 5, 2003, Pages 700-706

  Goto, Shunsuke ^a   Tsuboi, Hiroyuki ^a   Kanoda, Masami ^a   Mukai, Koji ^a   Kagara, Kooji ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSE REDUCTASE INHIBITOR; QUINAZOLINE DERIVATIVE; ZENARESTAT;

ALKYLATION; ARTICLE; COST EFFECTIVENESS ANALYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; LABORATORY; SAFETY; SCALE UP; SILYLATION; STEREOCHEMISTRY;

EID: 0141890130     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0340661     Document Type: Article

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18. Influences of impurities or additives to the plymorph control were reported in the following literature: (a) Ebian, A. R.; Moustafa, M. A.; Khalil, S. A.; Motawi, M. M. J. Pharm. Pharmacol. 1973, 25, 13-20. (b) Hasegawa, M.; Fukuda, N.; Higuchi, H.; Noguchi, S.; Matsubara, I. Agric. Biol. Chem. 1977, 41, 49. (c) Kitamura, M.; Funahara, H. J. Chem. Eng. Jpn. 1994, 27, 124-126. (d) Davey, R. J.; Blagden, N.; Potts, G. D.; Docherty, R. J. Am. Chem. Soc. 1997, 119, 1767-1772.
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