Isolation and identification of the major extractable impurity from Dowex 1x2 resin

Organic Process Research and Development

Volumn 7, Issue 5, 2003, Pages 750-753

  Tou, Jacob S ^a   Kostelc, James G ^a   Schlittler, Michael R ^b   Violand, Bernard N ^b  

^a MONSANTO COMPANY   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROMETHYL METHYL ETHER; PROPANOL; RESIN; STYRENE;

ARTICLE; COMMERCIAL PHENOMENA; EXTRACTION; MOLECULAR WEIGHT; MOLECULE;

EID: 0141890122     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op034044e     Document Type: Article

References (6)

1. Mindick, M.; Svarz, J. U.S. Patent 3,549,562, 1970.
2. The complete drug reference: United States Pharmacopeia [United States Pharmacopeial Convention, Inc.]; Consumer Reports Books: Yonkers, NY, 1990; Vol. XXII, p 304.
3. Johansson, B.-L. BioPharm. 1992, 34-37.
4. Knight, P. Bio/Technology 1989, 7, 777-782.
5. The pretreatment procedure was recommended by manufacturer Dow Chemicals to meet the CFR test requirements. U.S. Food, Drug, and Cosmetic Act Regulation Number CFR 173.25.
6. This was based on three batches of Dowex 1x2 resin available during the time of the studies.