Internalization of antibody-targeted immunonanoparticles into human hepatoma cells and its reversal effect on MDR

Journal of Sichuan University (Medical Science)

Volumn 34, Issue 3, 2003, Pages 431-434

  Liu, Xiaobo ^a   Wang, Xia ^a   Wei, Dapeng ^a   Cai, Meiying ^a   Li, Guang ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Human hepatoma; Immunonanoparticles; Internalization; Multidrug resistance

Indexed keywords

ANTIBODY; DOXORUBICIN; HUMAN SERUM ALBUMIN; NANOPARTICLE;

ANTIBODY SPECIFICITY; ARTICLE; CELL LINE; CELL STRUCTURE; COLORIMETRY; CYTOPLASM; CYTOTOXICITY; DRUG SENSITIVITY; FLUORESCENCE; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; IMMUNONANOPARTICLE; INTERNALIZATION; LASER MICROSCOPY; MULTIDRUG RESISTANCE; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0141890060     PISSN: 1672173X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Calafat J, Molthoff C, Janssen H, et al. Endocytosis and intracellular routing of an antibody ricin A chain conjuate. Cancer Res, 1988; 48 (13): 3822
2. Jones C, Burton M, Gray B. Albumin microspheres as vehicles for the sustained and controlled release of doxorubincin. J Pharm, Pharmacol, 1989; 41 (12): 813
3. Leek CC, Lee YJ, Kim WB, et al. Monoclonal antibody-based targeting of methotrexate-loaded microspheres. Int J Pharm, 1990; 59(1): 27
4. Flens M, Zaman G, Vander Valk P, et al. Tissue distribution of the mutidrug resistance protein. Amer J Pathol, 1996; 148 (4): 1237
5. Cuvier C, Treupel L, Millot J, et al. Doxorubicin-loaded nanospheres bypass tumour cell multidrug resistance. Biochem Pharmacol, 1992; 44(3): 509